2024
Sniffing out meaning: Chemosensory and semantic neural network changes in sommeliers
Carreiras M, Quiñones I, Chen H, Vázquez‐Araujo L, Small D, Frost R. Sniffing out meaning: Chemosensory and semantic neural network changes in sommeliers. Human Brain Mapping 2024, 45: e26564. PMID: 38339911, PMCID: PMC10823763, DOI: 10.1002/hbm.26564.Peer-Reviewed Original ResearchConceptsNeural circuitsFractional anisotropyRight superior longitudinal fasciculusSuperior longitudinal fasciculusRelevant sensory inputNeural network changesBrain responsesSemantic narrativesSemantic knowledgeMediation analysisPerceptual informationOlfactory circuitsLongitudinal fasciculusSensory processingChemosensory processingSensory neural circuitsVerbal descriptionsSemantic networkWine complexitySensory inputSemantic operationsWine tastingWine consumersTasting wineWine
2022
Olfactory decoding is positively associated with ad libitum food intake in sated humans
Perszyk EE, Davis XS, Small DM. Olfactory decoding is positively associated with ad libitum food intake in sated humans. Appetite 2022, 180: 106351. PMID: 36270421, DOI: 10.1016/j.appet.2022.106351.Peer-Reviewed Original ResearchConceptsAd libitum food intakeBody weight regulationFood intakeWeight regulationLong-term body weight regulationHealthy human adultsFunctional magnetic resonancePiriform cortexSatiety stateUnivariate analysisBody weightMeal consumptionPrevious functional magnetic resonanceNonfood odorsWeight changeBrain activationIntakeHuman adultsMulti-voxel pattern analysisHungry stateRole of olfactionOlfactory codingNeural patternsMagnetic resonanceAmygdalaFunctional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression
Kroemer NB, Opel N, Teckentrup V, Li M, Grotegerd D, Meinert S, Lemke H, Kircher T, Nenadić I, Krug A, Jansen A, Sommer J, Steinsträter O, Small DM, Dannlowski U, Walter M. Functional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression. JAMA Psychiatry 2022, 79: 993-1003. PMID: 36001327, PMCID: PMC9403857, DOI: 10.1001/jamapsychiatry.2022.2464.Peer-Reviewed Original ResearchConceptsMajor depressive disorderNAcc functional connectivityFunctional connectivityBody weightNucleus accumbensTreatment of MDDResting-state functional connectivityCase-control studySymptom-specific associationsHealthy control participantsIdentification of biomarkersClassification of diagnosesCohort studyMost patientsMean ageDepressive episodeDepressive disorderReduced appetiteMagnetic resonance imaging dataMAIN OUTCOMESubstantial burdenDepressive symptomsPatientsVentromedial prefrontal cortexReward circuitChronic pain precedes disrupted eating behavior in low-back pain patients
Lin Y, De Araujo I, Stanley G, Small D, Geha P. Chronic pain precedes disrupted eating behavior in low-back pain patients. PLOS ONE 2022, 17: e0263527. PMID: 35143525, PMCID: PMC8830732, DOI: 10.1371/journal.pone.0263527.Peer-Reviewed Original ResearchConceptsLow back pain patientsChronic low back pain patientsFat-rich foodsPain patientsChronic painCLBP patientsSBP patientsNucleus accumbensBack pain patientsChronic pain patientsHealthy control subjectsNucleus accumbens volumePain chronificationFat ingestionHedonic feedingPatient populationAccumbens volumeControl subjectsLimbic brainPainEarly coursePatientsBehavioral alterationsHedonic perceptionNeurological standpoint
2021
Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting
Laughlin M, Cooke B, Boutelle K, Savage CR, Kravitz A, Small D, Arvanitakis Z, Martin A, Stoeckel LE. Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting. International Journal Of Obesity 2021, 46: 718-725. PMID: 34934178, PMCID: PMC8960390, DOI: 10.1038/s41366-021-01025-8.Peer-Reviewed Original ResearchDietary lipids as regulators of reward processes: multimodal integration matters
Berland C, Small DM, Luquet S, Gangarossa G. Dietary lipids as regulators of reward processes: multimodal integration matters. Trends In Endocrinology And Metabolism 2021, 32: 693-705. PMID: 34148784, DOI: 10.1016/j.tem.2021.05.008.Peer-Reviewed Original ResearchConceptsDietary lipidsFunctional modulatorsModern food environmentLipid sensingPalatable dietObesity pandemicDopamine transmissionDA circuitsFeeding behaviorBody homeostasisDA signalingReward circuitRecent findingsDA systemEnergy-related signalsGenetic conditionsFood environmentFood overconsumptionNeural substratesLipidsRecent reportsSignalingRegulatorHomeostasisReward processesFat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity
Perszyk EE, Hutelin Z, Trinh J, Kanyamibwa A, Fromm S, Davis XS, Wall KM, Flack KD, DiFeliceantonio AG, Small DM. Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity. Nutrients 2021, 13: 1203. PMID: 33917347, PMCID: PMC8067354, DOI: 10.3390/nu13041203.Peer-Reviewed Original ResearchTracking smell loss to identify healthcare workers with SARS-CoV-2 infection
Weiss JJ, Attuquayefio TN, White EB, Li F, Herz RS, White TL, Campbell M, Geng B, Datta R, Wyllie AL, Grubaugh ND, Casanovas-Massana A, Muenker MC, Moore AJ, Handoko R, Iwasaki A, Martinello RA, Ko AI, Small DM, Farhadian SF, Team T. Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0248025. PMID: 33657167, PMCID: PMC7928484, DOI: 10.1371/journal.pone.0248025.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2 positive healthcare workersSmell lossHealthcare workersHome assessmentNeurological symptomsPositive SARS-CoV-2 testSARS-CoV-2 test positivitySARS-CoV-2 testPolymerase chain reaction testingReal-time quantitative polymerase chain reaction testingQuantitative polymerase chain reaction testingCOVID-19 patientsHigh-risk groupHigh-risk individualsSARS-CoV-2Self-reported changesProspective studyTest positivityAsymptomatic infectionSymptom SurveyVulnerable patientsHigh riskPositive testRisk individualsPost-traumatic olfactory loss and brain response beyond olfactory cortex
Pellegrino R, Farruggia MC, Small DM, Veldhuizen MG. Post-traumatic olfactory loss and brain response beyond olfactory cortex. Scientific Reports 2021, 11: 4043. PMID: 33597627, PMCID: PMC7889874, DOI: 10.1038/s41598-021-83621-2.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexOlfactory impairmentOlfactory cortexFunctional anosmiaPost-traumatic olfactory lossPrimary olfactory areasWhole-brain responsesBrain responsesGray matter densityHigher-order areasOlfactory lossPiriform cortexHead traumaHealthy controlsOlfactory areasOdorless stimuliOlfactory functionMediodorsal thalamusCortical areasVentromedial prefrontal cortexCingulate cortexFrontal operculumCortexAnterior insulaPrefrontal cortexFurther Evidence that Habitual Consumption of Sucralose with, but Not without, Carbohydrate Alters Glucose Metabolism
Dalenberg JR, Denis R, Luquet S, Small DM. Further Evidence that Habitual Consumption of Sucralose with, but Not without, Carbohydrate Alters Glucose Metabolism. Cell Metabolism 2021, 33: 227-228. PMID: 33535095, DOI: 10.1016/j.cmet.2021.01.006.Peer-Reviewed Original Research
2020
Neuroendocrinology and brain imaging
Preissl H, Small D, Kullmann S. Neuroendocrinology and brain imaging. Journal Of Neuroendocrinology 2020, 32: e12927. PMID: 33373090, DOI: 10.1111/jne.12927.Peer-Reviewed Original ResearchNo modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
Vosseler A, Zhao D, Fritsche L, Lehmann R, Kantartzis K, Small DM, Peter A, Häring HU, Birkenfeld AL, Fritsche A, Wagner R, Preißl H, Kullmann S, Heni M. No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men. Scientific Reports 2020, 10: 20466. PMID: 33235256, PMCID: PMC7686306, DOI: 10.1038/s41598-020-77430-2.Peer-Reviewed Original ResearchConceptsTranscutaneous auricular vagus nerve stimulationOral glucose tolerance testAuricular vagus nerve stimulationVagus nerve stimulationGlucose tolerance testAutonomic nervous systemNerve stimulationCatecholamine levelsTolerance testNervous systemHealthy lean menCross-over studyHeart rate variability parametersCross-over designWhole-body metabolismHeart rate variabilityMajor regulatory effectsLean menAutonomic innervationAutonomic toneHealthy menPlasma glucoseInsulin sensitivityPeripheral organsInsulin secretionDevelopment of MacroPics: A novel food picture set to dissociate the effects of carbohydrate and fat on eating behaviors
Fromm S, Perszyk EE, Kanyamibwa A, Wall KM, Hutelin Z, Trinh J, Davis XS, Green BG, Flack KD, DiFeliceantonio A, Small DM. Development of MacroPics: A novel food picture set to dissociate the effects of carbohydrate and fat on eating behaviors. Appetite 2020, 159: 105051. PMID: 33242580, DOI: 10.1016/j.appet.2020.105051.Peer-Reviewed Original ResearchCentral nervous pathways of insulin action in the control of metabolism and food intake
Kullmann S, Kleinridders A, Small DM, Fritsche A, Häring HU, Preissl H, Heni M. Central nervous pathways of insulin action in the control of metabolism and food intake. The Lancet Diabetes & Endocrinology 2020, 8: 524-534. PMID: 32445739, DOI: 10.1016/s2213-8587(20)30113-3.Peer-Reviewed Original ResearchConceptsPalatable food cuesCentral insulin actionCurrent findingsInsulin actionCognitive controlFood cuesCognitive healthPeripheral metabolismFood intakeMesocorticolimbic circuitryBrain insulin actionWhole-body insulin sensitivityCentral nervous pathwaysType 2 diabetesHuman researchCognitive diseasesEndogenous glucose productionDopamine systemNervous pathwaysTherapeutic optionsInsulin sensitivitySystemic metabolismAnimal modelsGlucose productionControl of metabolismIdentification of a brain fingerprint for overweight and obesity
Farruggia MC, van Kooten MJ, Perszyk EE, Burke MV, Scheinost D, Constable RT, Small DM. Identification of a brain fingerprint for overweight and obesity. Physiology & Behavior 2020, 222: 112940. PMID: 32417645, PMCID: PMC7321926, DOI: 10.1016/j.physbeh.2020.112940.Peer-Reviewed Original ResearchConceptsPercent body fatWaist circumferenceBody fatWhole-brain functional connectivityBrain network patternsGlucose toleranceBlood insulinObesityOverweightPathophysiological phenotypesFunctional connectivity networksFunctional connectivityMilkshake consumptionBrain correlatesBrain fingerprintsBMIAdiposityBrainCircumferenceConnectivity networksFatDiabetesPathophysiologyCentral roleInsulinIdentification of an Amygdala–Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions
Veldhuizen MG, Farruggia MC, Gao X, Nakamura Y, Green BG, Small DM. Identification of an Amygdala–Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions. Journal Of Neuroscience 2020, 40: 5051-5062. PMID: 32371606, PMCID: PMC7314406, DOI: 10.1523/jneurosci.2618-19.2020.Peer-Reviewed Original ResearchConceptsTaste intensity perceptionHealthy human participantsFunctional magnetic resonanceVentral posterior medial thalamusPosterior medial thalamusIntensity ratingsMedial dorsalMedial thalamusInhibitory outputInhibitory inputsPeripheral sourcesMagnetic resonanceInhibitory influenceIntensity perceptionCentral circuitsGustatory factorsIndividual variationDynamic causal modeling analysisConnectivity strengthAmygdalaMultiple tastantsGustatory systemMean intensity ratingsTaste intensity ratingsAmygdala responseLoss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signaturesCirculating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sørensen J, Cador M, Fioramonti X, Tschöp MH, Layé S, Venance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism 2020, 31: 773-790.e11. PMID: 32142669, PMCID: PMC7250662, DOI: 10.1016/j.cmet.2020.02.010.Peer-Reviewed Original ResearchConceptsDopamine receptor subtype 2Lipoprotein lipaseReceptor subtype 2Energy-rich dietDopaminergic transmissionMesocorticolimbic systemDietary triglyceridesSubtype 2Reward deficitsReward circuitMetabolic signaturesWeight gainCompulsive feedingFood cuesTriglyceridesGenetic riskBrain responsesNew mechanistic basisCompulsive behaviorsNeuronsNovel mechanismMechanistic basisDysfunctionShort-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S, Small DM. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metabolism 2020, 31: 493-502.e7. PMID: 32130881, PMCID: PMC7784207, DOI: 10.1016/j.cmet.2020.01.014.Peer-Reviewed Original ResearchConceptsGlucose metabolismPrevalence of obesityType 2 diabetesSugar-sweetened beveragesConsumption of sucraloseHealthy human participantsInsulin sensitivityTerm consumptionTaste perceptionMetabolismLong-term decreaseSweet tasteMetabolic sensitivityComorbiditiesGeneral consensusObesityDiabetesHuman participantsBeveragesMidbrainPrevalenceBrainSimilar relationship
2019
Rethinking Food Reward
de Araujo IE, Schatzker M, Small DM. Rethinking Food Reward. Annual Review Of Psychology 2019, 71: 1-26. PMID: 31561741, DOI: 10.1146/annurev-psych-122216-011643.Peer-Reviewed Original ResearchConceptsFood rewardReward regionsHedonic qualityBrain neural pathwaysSubliminal signalsCognitive processesBrain reward regionsConscious perceptionDietary decisionsCortical networksFlavor perceptionCaloric foodNeural pathwaysFood reinforcementRewardUncontrolled desirePerceptionDietary choicesOvereatingRecent animalHuman studiesTraditional modelsSensory receptorsDesireFindings