2020
Central nervous pathways of insulin action in the control of metabolism and food intake
Kullmann S, Kleinridders A, Small DM, Fritsche A, Häring HU, Preissl H, Heni M. Central nervous pathways of insulin action in the control of metabolism and food intake. The Lancet Diabetes & Endocrinology 2020, 8: 524-534. PMID: 32445739, DOI: 10.1016/s2213-8587(20)30113-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseBrainCentral Nervous SystemEatingEnergy MetabolismHumansHypoglycemic AgentsInsulinInsulin ResistanceConceptsPalatable food cuesCentral insulin actionCurrent findingsInsulin actionCognitive controlFood cuesCognitive healthPeripheral metabolismFood intakeMesocorticolimbic circuitryBrain insulin actionWhole-body insulin sensitivityCentral nervous pathwaysType 2 diabetesHuman researchCognitive diseasesEndogenous glucose productionDopamine systemNervous pathwaysTherapeutic optionsInsulin sensitivitySystemic metabolismAnimal modelsGlucose productionControl of metabolism
2017
Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward
Veldhuizen MG, Babbs RK, Patel B, Fobbs W, Kroemer NB, Garcia E, Yeomans MR, Small DM. Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward. Current Biology 2017, 27: 2476-2485.e6. PMID: 28803868, PMCID: PMC5745144, DOI: 10.1016/j.cub.2017.07.018.Peer-Reviewed Original ResearchConceptsCaloric loadGreater metabolic responseNon-linear associationMetabolic responseSugar-sweetened beveragesBrain responsesLow-calorie beveragesHigh-calorie beveragesNon-nutritive sweetenersGreater brain responsePost-ingestive signalsHuman studiesSweet tasteNutrient metabolismCarbohydrate metabolismNovel mechanismBeveragesPotencyAssociationMetabolismCarbohydrate rewards
2015
Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism
Burke MV, Small DM. Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism. Physiology & Behavior 2015, 152: 381-388. PMID: 26048305, PMCID: PMC4661139, DOI: 10.1016/j.physbeh.2015.05.036.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsBody WeightDrinking BehaviorEnergy MetabolismGastrointestinal MicrobiomeHumansNon-Nutritive SweetenersRewardConceptsNon-nutritive sweetenersNNS consumptionCognitive processesSugar-sweetened beverage consumptionNegative health outcomesMetabolic hormone secretionPotential biological mechanismsHormone secretionSSB intakeBody weightGut microbiotaSweet taste receptorBeverage consumptionHealth outcomesNNS useCentral mechanismsTaste receptorsBiological mechanismsMetabolic functionsPhysiological mechanismsMetabolismIntakeSecretionReceptors
2009
Individual differences in the neurophysiology of reward and the obesity epidemic
Small DM. Individual differences in the neurophysiology of reward and the obesity epidemic. International Journal Of Obesity 2009, 33: s44-s48. PMID: 19528979, PMCID: PMC2788336, DOI: 10.1038/ijo.2009.71.Peer-Reviewed Original ResearchMeSH KeywordsCuesEatingEnergy IntakeEnergy MetabolismEnvironmentFeeding BehaviorHumansLife StyleObesityRewardSatiation