2020
Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sørensen J, Cador M, Fioramonti X, Tschöp MH, Layé S, Venance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism 2020, 31: 773-790.e11. PMID: 32142669, PMCID: PMC7250662, DOI: 10.1016/j.cmet.2020.02.010.Peer-Reviewed Original ResearchConceptsDopamine receptor subtype 2Lipoprotein lipaseReceptor subtype 2Energy-rich dietDopaminergic transmissionMesocorticolimbic systemDietary triglyceridesSubtype 2Reward deficitsReward circuitMetabolic signaturesWeight gainCompulsive feedingFood cuesTriglyceridesGenetic riskBrain responsesNew mechanistic basisCompulsive behaviorsNeuronsNovel mechanismMechanistic basisDysfunction
2011
Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food
Stice E, Yokum S, Burger KS, Epstein LH, Small DM. Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food. Journal Of Neuroscience 2011, 31: 4360-4366. PMID: 21430137, PMCID: PMC3260083, DOI: 10.1523/jneurosci.6604-10.2011.Peer-Reviewed Original ResearchConceptsNormal weight humansObese humansStriatal responsesFood intakeOrbitofrontal cortexDopamine signalingWeight gainInitial vulnerability factorsGenetic riskStriatal D2 receptorsMonetary rewardsNormal-weight adolescentsPalatable food intakeD2 receptor densityD2 receptorsHigh-risk youthParietal operculumReceptor densitySomatosensory regionsPalatable foodFoods contributesFrontal operculumReward circuitryReduced dopamineObesity