2022
Olfactory decoding is positively associated with ad libitum food intake in sated humans
Perszyk EE, Davis XS, Small DM. Olfactory decoding is positively associated with ad libitum food intake in sated humans. Appetite 2022, 180: 106351. PMID: 36270421, DOI: 10.1016/j.appet.2022.106351.Peer-Reviewed Original ResearchConceptsAd libitum food intakeBody weight regulationFood intakeWeight regulationLong-term body weight regulationHealthy human adultsFunctional magnetic resonancePiriform cortexSatiety stateUnivariate analysisBody weightMeal consumptionPrevious functional magnetic resonanceNonfood odorsWeight changeBrain activationIntakeHuman adultsMulti-voxel pattern analysisHungry stateRole of olfactionOlfactory codingNeural patternsMagnetic resonanceAmygdala
2020
Identification of an Amygdala–Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions
Veldhuizen MG, Farruggia MC, Gao X, Nakamura Y, Green BG, Small DM. Identification of an Amygdala–Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions. Journal Of Neuroscience 2020, 40: 5051-5062. PMID: 32371606, PMCID: PMC7314406, DOI: 10.1523/jneurosci.2618-19.2020.Peer-Reviewed Original ResearchConceptsTaste intensity perceptionHealthy human participantsFunctional magnetic resonanceVentral posterior medial thalamusPosterior medial thalamusIntensity ratingsMedial dorsalMedial thalamusInhibitory outputInhibitory inputsPeripheral sourcesMagnetic resonanceInhibitory influenceIntensity perceptionCentral circuitsGustatory factorsIndividual variationDynamic causal modeling analysisConnectivity strengthAmygdalaMultiple tastantsGustatory systemMean intensity ratingsTaste intensity ratingsAmygdala response
2015
Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior
Kroemer NB, Sun X, Veldhuizen MG, Babbs AE, de Araujo IE, Small DM. Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior. NeuroImage 2015, 128: 273-283. PMID: 26724781, DOI: 10.1016/j.neuroimage.2015.12.031.Peer-Reviewed Original ResearchConceptsBrain responsesHigher body mass indexAd libitum food consumptionBody mass indexGreater weight lossNucleus Accumbens ResponseFunctional magnetic resonanceMilkshake receiptMass indexPlasma insulinPlasma glucoseMetabolic parametersDietary disinhibitionStriatal activityVariable response patternsWeight lossFood stimuliMetabolic responseSensory stimuliFood consumptionIntra-individual variationVariable responseMilkshakeMagnetic resonanceResponse patterns
2013
Verbal descriptors influence hypothalamic response to low-calorie drinks
Veldhuizen MG, Nachtigal DJ, Flammer LJ, de Araujo IE, Small DM. Verbal descriptors influence hypothalamic response to low-calorie drinks. Molecular Metabolism 2013, 2: 270-280. PMID: 24049739, PMCID: PMC3773823, DOI: 10.1016/j.molmet.2013.06.004.Peer-Reviewed Original Research
2011
Modality-Specific Neural Effects of Selective Attention to Taste and Odor
Veldhuizen MG, Small DM. Modality-Specific Neural Effects of Selective Attention to Taste and Odor. Chemical Senses 2011, 36: 747-760. PMID: 21685407, PMCID: PMC3175104, DOI: 10.1093/chemse/bjr043.Peer-Reviewed Original ResearchConceptsPrimary olfactory cortexPrimary taste cortexAnterior insular cortexInsular cortexOlfactory cortexTaste cortexPrimary gustatory cortexFunctional magnetic resonancePrimary olfactoryGustatory cortexModality-specific activationInsular responsesNeural effectsCortexBrain responsesMultimodal regionsTaste perceptionMagnetic resonanceGeneral effectSelective attentionActivationResponse
2010
Evidence for an Integrated Oral Sensory Module in the Human Anterior Ventral Insula
Rudenga K, Green B, Nachtigal D, Small DM. Evidence for an Integrated Oral Sensory Module in the Human Anterior Ventral Insula. Chemical Senses 2010, 35: 693-703. PMID: 20595201, PMCID: PMC2943409, DOI: 10.1093/chemse/bjq068.Peer-Reviewed Original ResearchConceptsAnterior ventral insulaVentral insulaOral stimulationTasteless control solutionFunctional magnetic resonanceVentral pallidumPhysiological significanceHarmful stimuliInsular responsesInsulaOral sensationNutritive stimulusModalitiesDifferential connectivityPresent studyStimulationMagnetic resonanceSensory modalitiesSubjectsHypothalamusStimuliStriatumPallidumGenetically Determined Differences in Brain Response to a Primary Food Reward
Felsted JA, Ren X, Chouinard-Decorte F, Small DM. Genetically Determined Differences in Brain Response to a Primary Food Reward. Journal Of Neuroscience 2010, 30: 2428-2432. PMID: 20164326, PMCID: PMC2831082, DOI: 10.1523/jneurosci.5483-09.2010.Peer-Reviewed Original ResearchConceptsBrain responsesPrimary food rewardFunctional magnetic resonanceTaqIA A1 alleleOrbital frontal cortexReward driveIndividual differencesNeural responsesFuture weight gainFood rewardPalatable foodNeuroimaging techniquesPerceptual responsesBiological underpinningsIndividual factorsFrontal cortexImpulsivityDiminished dopamineSimilar ratingsFood reinforcementRewardSpecific associationNeurophysiologyMilkshakeBody mass index
2009
Neural correlates of evaluative compared with passive tasting
Bender G, Veldhuizen MG, Meltzer JA, Gitelman DR, Small DM. Neural correlates of evaluative compared with passive tasting. European Journal Of Neuroscience 2009, 30: 327-338. PMID: 19614981, PMCID: PMC2776645, DOI: 10.1111/j.1460-9568.2009.06819.x.Peer-Reviewed Original ResearchConceptsLateral orbitofrontal cortexOrbitofrontal cortexPrimary taste cortexLeft lateral orbitofrontal cortexFunctional magnetic resonanceTasteless solutionMaximal responseTaste cortexFunction of taskCortical representationGustatory informationAnterior insulaVentral regionNeural responsesPreferential connectivityAmygdalaNeural correlatesCortexInsulaNeural encodingSubjectsStimulus presenceMagnetic resonanceResponseEarly relay
2007
Trying to Detect Taste in a Tasteless Solution: Modulation of Early Gustatory Cortex by Attention to Taste
Veldhuizen MG, Bender G, Constable RT, Small DM. Trying to Detect Taste in a Tasteless Solution: Modulation of Early Gustatory Cortex by Attention to Taste. Chemical Senses 2007, 32: 569-581. PMID: 17495173, DOI: 10.1093/chemse/bjm025.Peer-Reviewed Original Research