2021
Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018
Chouairi F, Mullan CW, Ravindra N, Clark KAA, Jaffe EM, Bhinder J, Fuery M, Guha A, Ahmad T, Desai NR. Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018. PLOS ONE 2021, 16: e0255514. PMID: 34591847, PMCID: PMC8483306, DOI: 10.1371/journal.pone.0255514.Peer-Reviewed Original ResearchVariants of the aortic arch in adult general population and their association with thoracic aortic aneurysm disease
Yousef S, Singh S, Alkukhun A, Alturkmani B, Mori M, Chen J, Mullan CW, Brooks CW, Assi R, Gruber PJ, Cortopassi I, Geirsson A, Vallabhajosyula P. Variants of the aortic arch in adult general population and their association with thoracic aortic aneurysm disease. Journal Of Cardiac Surgery 2021, 36: 2348-2354. PMID: 33855754, DOI: 10.1111/jocs.15563.Peer-Reviewed Original ResearchConceptsAortic arch anomaliesArch anomaliesAneurysm diseaseBovine archAberrant right subclavian arteryAdult populationThoracic aortic aneurysm diseasePrevalence of TAAsRight-sided archRight subclavian arteryCharacteristics of patientsIndependent risk factorAortic valve pathologyAdult general populationGeneral adult populationAortic aneurysm diseaseLogistic regression analysisSingle health systemFisher's exact testOlder adult populationBinary logistic regressionThoracic aortopathiesSubclavian arteryCommon diagnosisThoracic aneurysm
2020
Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure
Mezzacappa C, Ravindra NG, Caraballo C, Chouairi F, Miller PE, Clarke JD, Gruen J, Mori M, McCullough M, Mullan C, Geirsson A, Rogers JG, Anwer M, Desai N, Ahmad T. Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure. PLOS ONE 2020, 15: e0242928. PMID: 33270648, PMCID: PMC7714148, DOI: 10.1371/journal.pone.0242928.Peer-Reviewed Original ResearchConceptsClinical trialsVentricular assist deviceExclusion criteriaLVAD recipientsAssist deviceReal-world settingClinical implicationsClinical trial exclusion criteriaHeart failure clinical trialsEnd-stage renal diseaseEnd-stage heart failureReal-world registryRetrospective cohort studyLandmark clinical trialsStage renal diseaseTrial exclusion criteriaRisk of deathStage heart failureRespiratory failureCohort studyPatient characteristicsHeart failurePatient factorsRenal diseaseClinical outcomesTransition to Advanced Therapies in Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy
Chouairi F, Vallabhajosyula S, Mullan C, Mori M, Geirsson A, Desai NR, Ahmad T, Miller PE. Transition to Advanced Therapies in Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy. Journal Of Cardiac Failure 2020, 26: 1086-1089. PMID: 32777479, DOI: 10.1016/j.cardfail.2020.07.019.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationOrthotopic cardiac transplantationCardiogenic shockAdvanced therapiesVentricular assist device implantationNational Inpatient Sample databaseExtracorporeal membrane oxygenation therapyYounger groupStudy periodAssist device implantationMembrane oxygenation therapyProportion of patientsSurvival of patientsHospitalizations of peopleOlder age groupsHospital mortalityCardiac transplantationECMO supportMultivariable adjustmentElderly patientsLVAD implantationMembrane oxygenationOxygenation therapyPrimary outcomeDevice implantationSex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure
Gruen J, Caraballo C, Miller PE, McCullough M, Mezzacappa C, Ravindra N, Mullan CW, Reinhardt SW, Mori M, Velazquez E, Geirsson A, Ahmad T, Desai NR. Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure. JACC Heart Failure 2020, 8: 770-779. PMID: 32653446, DOI: 10.1016/j.jchf.2020.04.015.Peer-Reviewed Original ResearchConceptsAdverse eventsVentricular assist deviceClinical outcomesPotential underuseHigh riskAssist deviceEnd-stage heartWomen 65 yearsRisk of deathContinuous-flow LVADYears of ageAdvanced treatment optionsSex differencesHeart transplantationMultivariable adjustmentHeart failureHeart transplantSimilar incidenceTreatment optionsSimilar riskSurvival analysisLVADPatientsDevice malfunctionWomenPsychiatric Comorbidity and Outcomes After Left Ventricular Assist Device Implantation for End-Stage Heart Failure
Mullan C, Caraballo C, Ravindra NG, Miller PE, McCullough M, Brown K, Aw TW, Gruen J, Clarke JD, Velazquez EJ, Geirsson A, Mori M, Desai NR, Ahmad T. Psychiatric Comorbidity and Outcomes After Left Ventricular Assist Device Implantation for End-Stage Heart Failure. JACC Heart Failure 2020, 8: 569-577. PMID: 32535119, DOI: 10.1016/j.jchf.2020.03.011.Peer-Reviewed Original ResearchConceptsPsychiatric comorbidityMajor psychiatric illnessNarcotic dependencePsychiatric illnessAdverse eventsHeart failureAlcohol abuseKansas City Cardiomyopathy Questionnaire scoreDrug useVentricular assist device implantationEnd-stage heart failureMechanically Assisted Circulatory SupportAssist device implantationEnd-stage heartRisk of rehospitalizationContinuous-flow LVADRisk of mortalityVulnerable patient populationVentricular assist deviceDevice-related infectionsInteragency RegistryLVAD recipientsSpecific psychiatric conditionsClinical outcomesPatient selectionClinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantation
Mullan C, Caraballo C, Ravindra NG, Miller PE, Mori M, McCullough M, Clarke JD, Anwer M, Velazquez EJ, Geirsson A, Desai NR, Ahmad T. Clinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantation. The Journal Of Heart And Lung Transplantation 2020, 39: 926-933. PMID: 32593561, DOI: 10.1016/j.healun.2020.05.007.Peer-Reviewed Original ResearchConceptsConcomitant tricuspid valve proceduresTricuspid valve proceduresSevere tricuspid regurgitationTricuspid regurgitationLVAD implantationValve proceduresLeft ventricular assist device implantationVentricular assist device implantationDegree of TREnd-stage heart failureAssist device implantationRisk of bleedingCases of mildContinuous-flow LVADVentricular assist deviceInteragency RegistryAdult patientsAdverse eventsSurvival benefitHeart failureClinical outcomesDevice implantationTR severityQOL outcomesClinical impactCombined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair
Faggion Vinholo T, Mori M, Mahmood SUB, Mullan CW, Weininger G, Yousef S, Geirsson A. Combined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair. Seminars In Thoracic And Cardiovascular Surgery 2020, 32: 665-672. PMID: 32060011, DOI: 10.1053/j.semtcvs.2020.02.010.Peer-Reviewed Original ResearchConceptsDouble valve surgeryPerioperative adverse eventsTricuspid valve repairTricuspid regurgitationValve surgeryAdverse eventsValve repairMitral valveMitral positionValve functionTriple valve surgeryMid-term survivalLimited clinical evidenceSingle-institution seriesSubpopulation of patientsTricuspid valve functionMitral valve diseaseValve operationsLogistic regression modelsSignificant additional riskMultivalve surgeryPostoperative echocardiogramsPatient comorbiditiesMultivariable analysisClinical evidence
2019
Clinical Outcomes After Left Ventricular Assist Device Implantation in Older Adults An INTERMACS Analysis
Caraballo C, DeFilippis EM, Nakagawa S, Ravindra NG, Miller PE, Mezzacappa C, McCullough M, Gruen J, Levin A, Reinhardt S, Mullan C, Ali A, Maurer MS, Desai NR, Ahmad T, Topkara VK. Clinical Outcomes After Left Ventricular Assist Device Implantation in Older Adults An INTERMACS Analysis. JACC Heart Failure 2019, 7: 1069-1078. PMID: 31779930, DOI: 10.1016/j.jchf.2019.10.004.Peer-Reviewed Original ResearchConceptsYears of ageVentricular assist device implantationAssist device implantationOlder adultsElderly patientsLVAD implantationDevice implantationMultivariate Cox proportional hazards regression modelCox proportional hazards regression modelKaplan-Meier survival estimatesMechanically Assisted Circulatory SupportProportional hazards regression modelsMechanical circulatory support technologyPost-LVAD outcomesHeart failure populationLog-rank testingSerum albumin levelPredictors of survivalPost-LVAD implantationHazards regression modelsPredictors of outcomeAge-specific outcomesAntithrombotic regimenDurable MCSINTERMACS AnalysisClinical significance of presenting syndromes on outcome after coronary artery bypass grafting
Bin Mahmood SU, Mori M, Yousef S, Mullan CW, Mangi AA, Geirsson A. Clinical significance of presenting syndromes on outcome after coronary artery bypass grafting. Interdisciplinary CardioVascular And Thoracic Surgery 2019, 30: 243-248. PMID: 31713612, DOI: 10.1093/icvts/ivz259.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeStable ischemic heart diseaseCox proportional hazards modelCoronary artery bypassMid-term survivalIschemic heart diseaseProportional hazards modelPresenting syndromeArtery bypassHeart diseaseHazards modelMortality rateMultivariable Cox proportional hazards modelsMultivariate Cox proportional hazards modelMid-term mortality ratesSingle-center retrospective studyConsecutive CABG operationsMid-term mortalityCongestive heart failurePost-discharge survivalLong-term followIntensive care unitOverall mean durationMore comorbiditiesCABG operationsUS National Trends in the Management and Outcomes of Constrictive Pericarditis: 2005-2014
Mori M, Mullan CW, Bin Mahmood SU, Yousef S, Pelletier KJ, Mangi AA, Geirsson A. US National Trends in the Management and Outcomes of Constrictive Pericarditis: 2005-2014. Canadian Journal Of Cardiology 2019, 35: 1394-1399. PMID: 31493971, DOI: 10.1016/j.cjca.2019.05.015.Peer-Reviewed Original ResearchConceptsConstrictive pericarditisPatient characteristicsNational Inpatient Sample datasetHospital mortality rateOutcomes of patientsProportion of patientsCardiopulmonary bypass useUS national trendsUse of CPBUS Census population estimatesCensus population estimatesPoisson regression modelsCPB useHospital mortalityOperative mortalityComorbid patientsSurgical managementBypass usePericarditisMortality ratePatientsPericardiectomyCohortNational trendsMortality
2015
Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial
Lindesmith LC, Ferris MT, Mullan CW, Ferreira J, Debbink K, Swanstrom J, Richardson C, Goodwin RR, Baehner F, Mendelman PM, Bargatze RF, Baric RS. Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial. PLOS Medicine 2015, 12: e1001807. PMID: 25803642, PMCID: PMC4371888, DOI: 10.1371/journal.pmed.1001807.Peer-Reviewed Original ResearchConceptsTime of vaccinationAb responsesVLP vaccineHuman volunteersProtective immunityAb titersCandidate vaccinesEffective NoV vaccinesPhase I ClinicalCross-strain protectionSurrogate neutralization assayBlockade antibodiesAb blockadeNoV infectionBlockade assayAcute gastroenteritisImmune responseNeutralization assaysNoV vaccinesVaccine componentsPredominant GIIMultiple epitopesVaccinationPrevious exposure historyAntigenic drift