The Impact of Depression on Outcomes in Patients With Heart Failure and Reduced Ejection Fraction Treated in the GUIDE-IT Trial
Chouairi F, Fuery MA, Mullan CW, Caraballo C, Sen S, Maulion C, Wilkinson ST, Surti T, McCullough M, Miller PE, Pacor J, Leifer ES, Felker GM, Velazquez EJ, Fiuzat M, O'Connor CM, Januzzi JL, Desai NR, Ahmad T. The Impact of Depression on Outcomes in Patients With Heart Failure and Reduced Ejection Fraction Treated in the GUIDE-IT Trial. Journal Of Cardiac Failure 2021, 27: 1359-1366. PMID: 34166799, DOI: 10.1016/j.cardfail.2021.06.008.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyReduced ejection fractionAmino-terminal pro-B-type natriuretic peptide levelsPro-B-type natriuretic peptide levelsGUIDE-IT trialNatriuretic peptide levelsHeart failureEjection fractionClinical outcomesPeptide levelsOptimal guideline-directed medical therapyCox proportional hazards regression modelingProportional hazards regression modelingImpact of depressionHistory of depressionCardiovascular deathCause hospitalizationCause mortalityOverall cohortMedical therapyAdverse outcomesTarget dosesPatientsMental healthTime pointsImpact of chronic lung disease on quality‐of‐life outcomes in patients undergoing transcatheter aortic valve replacement
Catalano MA, Lin D, Mullan CW, Cassiere H, Rutkin B, Maurer G, Berg J, Hartman A, Yu P. Impact of chronic lung disease on quality‐of‐life outcomes in patients undergoing transcatheter aortic valve replacement. Journal Of Cardiac Surgery 2021, 36: 672-677. PMID: 33403744, DOI: 10.1111/jocs.15248.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementChronic lung diseaseAortic valve replacementAortic stenosisLung diseaseValve replacementKansas City Cardiomyopathy Questionnaire-12Concomitant severe aortic stenosisLower baseline ejection fractionPreoperative pulmonary function testsSTS Predicted RiskSevere aortic stenosisBaseline ejection fractionPeripheral artery diseasePulmonary function testsObstructive lung diseaseSignificant differencesKCCQ-12TAVR patientsPostoperative outcomesSymptomatic improvementArtery diseaseEjection fractionRetrospective reviewFunction tests