2024
Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation
Alashi A, Vermillion B, Callegari S, Burns R, Guo L, Moulton E, Guerrera N, Depino A, Papademetris X, Zeiss C, Thorn S, Liu C, Sinusas A. Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.087. DOI: 10.1093/ehjci/jeae142.087.Peer-Reviewed Original ResearchPeripheral arterial diseaseStandardized uptake valueHindlimb ischemia modelReactive hyperemiaSkeletal muscle perfusionPerfusion reserveCapillary densityPET imagingArtery diseaseNon-ischemicRubidium-82 positron emission tomographyType 2 muscle fibersRelevant pre-clinical modelIndicative of fibrosisManagement of peripheral arterial diseaseCapillary to muscle fiber ratioClinically relevant pre-clinical modelPre-clinical modelsMuscle perfusionFast myosinWeeks post-ligationRb-82 uptakeEvaluate treatment strategiesRabbit hindlimb ischemia modelPositron emission tomography
2022
The Impact of Additional Sampling on Hot-Spot Contrast for DE-SPECT
Metzler S, Zannoni E, Sankar P, Liu C, Sinusas A, Meng L. The Impact of Additional Sampling on Hot-Spot Contrast for DE-SPECT. 2022, 00: 1-4. DOI: 10.1109/nss/mic44845.2022.10399030.Peer-Reviewed Original ResearchHot spot phantomCollimator configurationCZT moduleAxial shiftDetector positionSensitivity dropsSample positionHot spotsNominal positionPhantomPeripheral arterial diseaseOptimal contrastCollimatorActuator switchingCZTArtery diseaseNoise levelDetectorConfigurationSmall axial shiftsShiftEvaluate contrastOptimal tradeoff