2024
Trauma‐Focused Cognitive‐Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study
Lydecker J, Ozbardakci E, Lou R, Grilo C. Trauma‐Focused Cognitive‐Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study. International Journal Of Eating Disorders 2024, 57: 2117-2127. PMID: 39007703, DOI: 10.1002/eat.24257.Peer-Reviewed Original ResearchCognitive-behavioral therapyTraumatic stressClinically-meaningful improvementsTrauma-focused cognitive behavioral therapyTrauma-focused cognitive-behavioral therapyPatient outcomesOvervaluation of weight/shapeSymptoms of traumatic stressWeight-related bullyingCognitive behavioral therapyCognitive-behavioralTrauma-focusedWithin-subject improvementIntrusive symptomsBehavioral therapyDietary restraintEating disordersTherapyTreatment satisfactionFunctional impairmentTreatment feasibilityAdolescentsPatientsWeight/shapeFeasibility trialTreatment of Eating Disorders: Current Status, Challenges, and Future Directions
Grilo C. Treatment of Eating Disorders: Current Status, Challenges, and Future Directions. Annual Review Of Clinical Psychology 2024, 20: 97-123. PMID: 38211625, DOI: 10.1146/annurev-clinpsy-080822-043256.Peer-Reviewed Original ResearchAnorexia nervosaBinge-eating disorderBulimia nervosaEating disordersAdaptive treatment designsPsychological treatmentTreatment researchNervosaTreatment designDisordersBulimiaPharmacological optionsAnorexiaEnhanced outcomesExpected final online publication dateFirst-line approachOnline publication dateMedicationFirst-lineClinical guidanceAnnual ReviewAlternative treatmentRevised estimatesPatientsTreatment
2023
Shape discrepancy, weight bias internalization, and eating-disorder psychopathology in patients with loss-of-control eating after bariatric surgery
Dunford A, Ivezaj V, Grilo C. Shape discrepancy, weight bias internalization, and eating-disorder psychopathology in patients with loss-of-control eating after bariatric surgery. Surgery For Obesity And Related Diseases 2023, 20: 291-296. PMID: 37926627, PMCID: PMC10922050, DOI: 10.1016/j.soard.2023.09.028.Peer-Reviewed Original ResearchBariatric surgeryEating Disorder Examination-Bariatric Surgery Version interviewControl eatingCurrent body mass indexWeight lossPoor weight lossBody mass indexED psychopathologyEating-disorder psychopathologyMental health outcomesPostoperative interventionsPostoperative lossEating Disorder PsychopathologyMass indexPercent weight lossResults Most participantsWeight bias internalizationSurgeryYale University SchoolHealth outcomesPatientsSomatic concernsWeight concernsMost participantsMethods ParticipantsRacial differences after bariatric surgery: 24-month follow-up of a randomized, controlled trial for postoperative loss-of-control eating
Ivezaj V, Dilip A, Duffy A, Grilo C. Racial differences after bariatric surgery: 24-month follow-up of a randomized, controlled trial for postoperative loss-of-control eating. Surgery For Obesity And Related Diseases 2023, 20: 261-266. PMID: 37949690, PMCID: PMC10922356, DOI: 10.1016/j.soard.2023.09.017.Peer-Reviewed Original ResearchEating-disorder psychopathologyPercent excess weight lossExcess weight lossPost-bariatric surgeryNon-white patientsWhite patientsEating Disorder Examination-Bariatric Surgery Version interviewGreater percent excess weight lossGreater eating-disorder psychopathologyMonths post-bariatric surgeryWeight lossBDI-II depression scoreLong-term outcomesPost-operative lossRacial differencesAcademic medical centerBeck Depression InventoryBariatric surgeryShort-term findingsControlled TrialsProspective studyMedical CenterDepression scoresBetter outcomesPatientsNaltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionImprovements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Yurkow S, Ivezaj V, Grilo C. Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity. International Journal Of Eating Disorders 2023, 56: 2074-2083. PMID: 37530200, PMCID: PMC10834830, DOI: 10.1002/eat.24035.Peer-Reviewed Original ResearchConceptsCardiovascular disease risk factorsModest weight lossDisease risk factorsBinge-eating disorderPlasma glucoseRisk factorsWeight lossLifestyle changesBehavioral lifestyle changesCardiovascular disease riskWeight loss treatmentSignificant improvementRelated lifestyle changesTotal cholesterolPotential health benefitsHeart ratePatientsObesityDisease riskHbA1cHealth benefitsDisordersTriglyceridesTreatmentPosttreatmentPredictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating
Smith C, Dilip A, Ivezaj V, Duffy A, Grilo C. Predictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating. Clinical Obesity 2023, 13: e12603. PMID: 37257889, PMCID: PMC10524670, DOI: 10.1111/cob.12603.Peer-Reviewed Original ResearchConceptsEarly weight lossAdjunctive behavioral treatmentsPost-bariatric surgery patientsEarly weight changeBaseline patient characteristicsSurgery-related variablesMonths of treatmentWeight lossBehavioral treatmentPatient characteristicsSurgery patientsFirst monthWeight changeTime of surgeryWeight gain groupEating-disorder psychopathologyBariatric surgeryMost patientsAdjunctive treatmentBlack patientsPercent weight lossPsychiatric comorbidityClinical variablesTreatment trialsPatientsCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapyPredictors and significance of rapid response to behaviorally based treatment of binge eating disorder
Yurkow S, Ivezaj V, Grilo C. Predictors and significance of rapid response to behaviorally based treatment of binge eating disorder. Obesity 2023, 31: 390-398. PMID: 36623872, PMCID: PMC9877118, DOI: 10.1002/oby.23648.Peer-Reviewed Original ResearchConceptsDemographic featuresTreatment attitudesWeight lossFourth treatment weekWeight loss outcomesPsychiatric variablesSuperior clinical outcomesWeight loss treatmentTreatment of bingeClinical severity variablesClinical outcomesPrognostic significanceTreatment weekClinical trialsBaseline predictorsLoss outcomesLoss treatmentPosttreatment outcomesBinge eatingIndependent assessorsBingeSeverity variablesDisordersPatientsTreatment
2022
Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy
Forrest L, Franko D, Thompson‐Brenner H, Grilo C. Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy. International Journal Of Eating Disorders 2022, 56: 944-955. PMID: 36565241, PMCID: PMC10159900, DOI: 10.1002/eat.23883.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive behavioral therapyEvidence-based treatmentsInterpersonal psychotherapyIntervention targetsBinge-eating disorder symptomsBehavioral therapyIndicator of remissionShape concernsRefinement of treatmentClinical utilityFrequent associationClinical implicationsSymptomsSymptom interactionsTherapyInterpersonal therapyWeight concernsDisorder symptomsSymptom relationshipsDisordersPatientsTreatmentSizeable minorityNetwork of symptoms
2017
Back to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up
Barnes RD, Ivezaj V, Martino S, Pittman BP, Grilo CM. Back to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up. Obesity 2017, 25: 2074-2078. PMID: 29086484, PMCID: PMC5705439, DOI: 10.1002/oby.21972.Peer-Reviewed Original ResearchConceptsWeight loss interventionPrimary careBinge-eating disorderWeight lossNutrition psychoeducationLoss interventionSecondary end point analysisWeight loss 12 monthsAttention-controlled comparisonMotivational interviewingMIC patientsEnd-point analysisTreatment conclusionOne-yearBed statusSmall effect sizesCareMonthsPatientsInterventionEffect sizeTreatmentPsychoeducationLong-term impactMixed modelsPsychological and Behavioral Treatments for Binge-Eating Disorder.
Grilo CM. Psychological and Behavioral Treatments for Binge-Eating Disorder. The Journal Of Clinical Psychiatry 2017, 78 Suppl 1: 20-24. PMID: 28125175, DOI: 10.4088/jcp.sh16003su1c.04.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBehavioral treatmentBehavioral weight loss therapyCognitive behavioral therapyBinge Eating DisorderBehavioral treatment optionsInterpersonal psychotherapyIntervention protocolBetter outcomesSignificant predictorsWeight lossModest weight lossWeight loss therapyBody shapeReliable predictorTreatment outcomesLoss therapyTreatment optionsDisordersInterventionModeratorPredictorsPsychotherapyPatientsTherapy
2016
Preferred descriptions for loss of control while eating and weight among patients with binge eating disorder
Roberto CA, Galbraith K, Lydecker JA, Ivezaj V, Barnes RD, White MA, Grilo CM. Preferred descriptions for loss of control while eating and weight among patients with binge eating disorder. Psychiatry Research 2016, 246: 548-553. PMID: 27821368, PMCID: PMC5161684, DOI: 10.1016/j.psychres.2016.09.045.Peer-Reviewed Original Research[PP.13.07] HYPERTENSION AND CARDIOVASCULAR DISEASE RISK REDUCTION IN OBESE PATIENTS WITH BINGE EATING DISORDER
Grilo C. [PP.13.07] HYPERTENSION AND CARDIOVASCULAR DISEASE RISK REDUCTION IN OBESE PATIENTS WITH BINGE EATING DISORDER. Journal Of Hypertension 2016, 34: e192-e193. DOI: 10.1097/01.hjh.0000491879.94394.fc.Peer-Reviewed Original ResearchBinge-eating disorderAnti-obesity medicationsCVD risk factorsObese patientsBlood pressureMetabolic syndromeCardiovascular disease risk reductionStepped-care treatmentSubgroup of patientsDisease risk reductionMental Health SurveyObese BED patientsBinge Eating DisorderCognitive behavioral therapyOverall significant decreaseMedical comorbiditiesRemission rateRisk factorsInitial respondersHealth SurveyHeart rateBED patientsHypertensionMixed model analysisPatientsRandomized controlled trial testing behavioral weight loss versus multi-modal stepped-care treatment for binge eating disorder
Grilo C. Randomized controlled trial testing behavioral weight loss versus multi-modal stepped-care treatment for binge eating disorder. European Psychiatry 2016, 33: s163. DOI: 10.1016/j.eurpsy.2016.01.321.Peer-Reviewed Original ResearchStepped-care treatmentAnti-obesity medicationsRemission rateWeight lossBehavioral weight lossCo-morbid obesityStepped-care modelObese BED patientsSignificant time effectInitial respondersTreatment challengesBED patientsMedicationsMixed model analysisPatientsBingePlaceboMonthsObesityBWLTreatmentStructured interviewsCBTDisordersMixed modelsSex Differences and Correlates of Pain in Patients with Comorbid Obesity and Binge Eating Disorder
Masheb RM, White MA, Grilo CM. Sex Differences and Correlates of Pain in Patients with Comorbid Obesity and Binge Eating Disorder. European Eating Disorders Review 2016, 24: 247-250. PMID: 26841114, PMCID: PMC4821688, DOI: 10.1002/erv.2432.Peer-Reviewed Original ResearchConceptsCorrelates of painMetabolic risk factorsRisk factorsHigh-density lipoprotein cholesterolObesity-related health risksBrief Pain InventoryPresence of painGreater pain severitySample of patientsSex differencesTreatment-seeking patientsComorbid obesityLipoprotein cholesterolPain severityPain InventoryComorbid painPain interferenceMore painPainMetabolic markersBinge frequencyAnalysis of covarianceComorbid bingeClinical implicationsPatients
2015
Cardiovascular disease risk reduction in patients with binge eating disorder and obesity: Randomized controlled trial of stepped-care versus standard behavioral weight loss
Grilo C. Cardiovascular disease risk reduction in patients with binge eating disorder and obesity: Randomized controlled trial of stepped-care versus standard behavioral weight loss. Atherosclerosis 2015, 241: e19. DOI: 10.1016/j.atherosclerosis.2015.04.081.Peer-Reviewed Original ResearchComorbidity of mood and substance use disorders in patients with binge-eating disorder: Associations with personality disorder and eating disorder pathology
Becker DF, Grilo CM. Comorbidity of mood and substance use disorders in patients with binge-eating disorder: Associations with personality disorder and eating disorder pathology. Journal Of Psychosomatic Research 2015, 79: 159-164. PMID: 25700727, PMCID: PMC4492840, DOI: 10.1016/j.jpsychores.2015.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBinge-Eating DisorderBody Mass IndexBody WeightComorbidityDiagnosis, Dual (Psychiatry)Diagnostic and Statistical Manual of Mental DisordersEatingFeeding and Eating DisordersFemaleHumansMaleMiddle AgedMood DisordersPersonality DisordersSubstance-Related DisordersYoung AdultConceptsBinge-eating disorderSubstance use disordersMood disordersUse disordersDisorder psychopathologyPersonality disorder featuresDSM-IV research criteriaDSM-IV Axis IComorbidity of moodPersonality disorderAdditional comparison groupBody mass indexCo-occurring mood disordersLifetime DSM-IV Axis IAge of onsetDisorder featuresSuch comorbiditiesMass indexPsychiatric comorbidityDisorder onsetComorbiditiesAxis IBED patientsPatientsControl group
2014
Factor structure and clinical utility of the Beck Depression Inventory in patients with binge eating disorder and obesity
Udo T, McKee SA, Grilo CM. Factor structure and clinical utility of the Beck Depression Inventory in patients with binge eating disorder and obesity. General Hospital Psychiatry 2014, 37: 120-125. PMID: 25537344, PMCID: PMC4361288, DOI: 10.1016/j.genhosppsych.2014.11.011.Peer-Reviewed Original ResearchConceptsBeck Depression InventoryObese patientsMood disordersClinical utilityDepression InventoryDisorder psychopathologyHigh negative predictive valueMajor depressive disorderNegative predictive valueTreatment-seeking obese patientsExcellent internal consistencyDepressive disorderSelf-report questionnairesDepression symptomsPredictive valuePatientsThree-factor structureScreening instrumentDisordersObesityVariable associationsInternal consistencyA randomized controlled trial comparing scalable weight loss treatments in primary care
Barnes RD, White MA, Martino S, Grilo CM. A randomized controlled trial comparing scalable weight loss treatments in primary care. Obesity 2014, 22: 2508-2516. PMID: 25298016, PMCID: PMC4236282, DOI: 10.1002/oby.20889.Peer-Reviewed Original ResearchConceptsNutrition psychoeducationUsual careAttention control interventionMotivational interviewingTreatment adherenceWeight lossOverweight/obese patientsBed statusWeight loss outcomesPrimary care settingWeight loss treatmentWeight loss resultsObese patientsTriglyceride levelsPrimary careObesity interventionsNPC patientsLoss outcomesLoss treatmentDepression scoresScalable interventionsPatientsTreatment disseminationSuperior benefitsIntervention