2007
Schwann Cell Transplantation Improves Reticulospinal Axon Growth and Forelimb Strength after Severe Cervical Spinal Cord Contusion
Schaal SM, Kitay BM, Cho KS, Lo TP, Barakat DJ, Marcillo AE, Sanchez AR, Andrade CM, Pearse DD. Schwann Cell Transplantation Improves Reticulospinal Axon Growth and Forelimb Strength after Severe Cervical Spinal Cord Contusion. Cell Transplantation 2007, 16: 207-228. PMID: 17503734, DOI: 10.3727/000000007783464768.Peer-Reviewed Original ResearchConceptsSpinal cord injuryAxon growthNeuroprotective efficacyCervical spinal cord contusionInjury/graft siteCell bodiesThoracic spinal cord injurySchwann cell transplantationSpinal cord contusionThoracic spinal cordAdult female Fischer ratsFemale Fischer ratsSchwann cell implantationUpper limb strengthSignificant behavioral improvementCervical contusionInjury epicenterCord contusionUpper body strengthWeeks postinjuryBBB scoresSC implantsSupraspinal axonsCell transplantationCord injury
2005
Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue.
Blits B, Kitay BM, Farahvar A, Caperton CV, Dietrich WD, Bunge MB. Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue. Restorative Neurology And Neuroscience 2005, 23: 313-24. PMID: 16477093.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain InjuriesCell MovementCells, CulturedDisease Models, AnimalEmbryo, MammalianFemaleGenetic VectorsGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsImmunohistochemistryIntermediate Filament ProteinsLentivirusNerve Growth FactorsNerve Tissue ProteinsNestinNeuronsRatsRats, Inbred F344Rats, Sprague-DawleySpinal Cord InjuriesStem Cell TransplantationStem CellsTransduction, GeneticTubulinConceptsNeural progenitor cellsSpinal cordNeurotrophic factorPositive cellsGFP-positive cellsContused spinal cordProgenitor cellsSpinal cord lesionsCortical neural progenitor cellsLong-term transgene expressionLentiviral vectorsRat spinal cordLentiviral vector-mediated transductionCord lesionsGreen fluorescent proteinReplacement therapyCell replacement therapyVector-mediated transductionNPC survivalLesion siteAstrocytic phenotypeImmune rejectionCordNeurological disordersNon-transduced cells