2019
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses
Jiang X, Muthusamy V, Fedorova O, Kong Y, Kim DJ, Bosenberg M, Pyle AM, Iwasaki A. Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses. Journal Of Experimental Medicine 2019, 216: 2854-2868. PMID: 31601678, PMCID: PMC6888973, DOI: 10.1084/jem.20190801.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsAntineoplastic Agents, ImmunologicalCD8-Positive T-LymphocytesDose-Response Relationship, DrugGene Expression ProfilingImmunologic MemoryInjections, IntralesionalMaleMelanoma, ExperimentalMiceOligoribonucleotidesProgrammed Cell Death 1 ReceptorReceptors, Cell SurfaceTumor BurdenConceptsAntitumor responseNucleic acid-sensing pathwaysSignificant tumor growth delayNumber of CD8Systemic antitumor responseRobust antitumor responseAnti-PD1 antibodyB16 tumor growthImmunogenic tumor modelsCytosolic nucleic acid-sensing pathwaysSingle-agent treatmentTumor growth delayTumor metastasis modelNK cellsMetastasis modelT lymphocytesImmune responseExtended survivalIntratumoral deliveryImmune memoryMyeloid cellsTumor growthGrowth delayTumor microenvironmentTumor model
2016
Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence
Molinari E, Bar H, Pyle AM, Patrizio P. Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence. Molecular Human Reproduction 2016, 22: 866-876. PMID: 27268410, PMCID: PMC4986421, DOI: 10.1093/molehr/gaw038.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell HypoxiaCumulus CellsFemaleGene Expression ProfilingHumansOocytesOvarian FollicleOvulation InductionPregnancySequence Analysis, RNATranscriptomeConceptsRNA sequencingHuman cumulus cellsCumulus cellsGEO accession numberHypoxia stress responseWhole transcriptome analysisTranscriptome analysisSomatic cellsEmbryonic developmentBioinformatics toolsGene pathwaysSpecific molecular findingsAccession numbersCell agingMolecular mechanismsStress responseVasculature developmentGenetic differencesSAMPLES/MATERIALSGenetic platformMolecular pathwaysReproductive potentialCAMP turnoverGenesSenescence