2023
Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy
Wang Y, Malik S, Suh H, Xiao Y, Deng Y, Fan R, Huttner A, Bindra R, Singh V, Saltzman W, Bahal R. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances 2023, 9: eabq7459. PMID: 36753549, PMCID: PMC9908025, DOI: 10.1126/sciadv.abq7459.Peer-Reviewed Original ResearchConceptsConvection-enhanced deliveryHigh recurrence rateOrthotopic mouse modelBrain tumor therapyTreatment of glioblastomaRecurrence ratePoor survivalLethal malignancyMouse modelGBM progressionTumor cellsGlioblastomaTumor therapyBioadhesive nanoparticlesOncomiRSurvivalTreatmentSeed regionMalignancyTemozolomideTherapy
2021
Nocardia thailandica Brain Abscess in an Immunocompromised Patient
Effendi M, Tirmizi S, McManus D, Huttner AJ, Peaper DR, Topal JE. Nocardia thailandica Brain Abscess in an Immunocompromised Patient. Case Reports In Infectious Diseases 2021, 2021: 6620049. PMID: 34234968, PMCID: PMC8216818, DOI: 10.1155/2021/6620049.Peer-Reviewed Original ResearchSuccessful treatmentCentral nervous system infectionRadiographic treatment successInitiation of therapyNervous system infectionCeftriaxone 2Ceftriaxone monotherapyRadiological improvementBrain abscessesSystem infectionMedical therapyTreatment successCNS penetrationPatientsMedical literatureInfectionBrainTherapyTreatmentMonthsMonotherapyAbscessCeftriaxoneCraniotomy