2023
Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy
Wang Y, Malik S, Suh H, Xiao Y, Deng Y, Fan R, Huttner A, Bindra R, Singh V, Saltzman W, Bahal R. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances 2023, 9: eabq7459. PMID: 36753549, PMCID: PMC9908025, DOI: 10.1126/sciadv.abq7459.Peer-Reviewed Original ResearchConceptsConvection-enhanced deliveryHigh recurrence rateOrthotopic mouse modelBrain tumor therapyTreatment of glioblastomaRecurrence ratePoor survivalLethal malignancyMouse modelGBM progressionTumor cellsGlioblastomaTumor therapyBioadhesive nanoparticlesOncomiRSurvivalTreatmentSeed regionMalignancyTemozolomideTherapy
2022
Histological changes associated with laser interstitial thermal therapy for radiation necrosis: illustrative cases
Fomchenko EI, Leelatian N, Darbinyan A, Huttner AJ, Chiang VL. Histological changes associated with laser interstitial thermal therapy for radiation necrosis: illustrative cases. Journal Of Neurosurgery Case Lessons 2022, 4: case21373. PMID: 35855352, PMCID: PMC9257400, DOI: 10.3171/case21373.Peer-Reviewed Original ResearchLaser interstitial thermal therapyRadiation necrosisInterstitial thermal therapyBrain metastasesAssociated cerebral edemaStage IV diseaseUse of immunotherapyPredictors of responseOngoing immunotherapySurgical decompressionCerebral edemaPerilesional edemaSurgical approachClinical historyLung cancerNeurological compromiseGood patientHistological changesStereotactic radiosurgeryPatientsEarly reductionSized lesionsImmunotherapyTherapyThermal therapy
2021
Nocardia thailandica Brain Abscess in an Immunocompromised Patient
Effendi M, Tirmizi S, McManus D, Huttner AJ, Peaper DR, Topal JE. Nocardia thailandica Brain Abscess in an Immunocompromised Patient. Case Reports In Infectious Diseases 2021, 2021: 6620049. PMID: 34234968, PMCID: PMC8216818, DOI: 10.1155/2021/6620049.Peer-Reviewed Original ResearchSuccessful treatmentCentral nervous system infectionRadiographic treatment successInitiation of therapyNervous system infectionCeftriaxone 2Ceftriaxone monotherapyRadiological improvementBrain abscessesSystem infectionMedical therapyTreatment successCNS penetrationPatientsMedical literatureInfectionBrainTherapyTreatmentMonthsMonotherapyAbscessCeftriaxoneCraniotomyGenomic Characterization of Radiation‐Induced Intracranial Undifferentiated Pleomorphic Sarcoma
Hong CS, Partovi E, Clune J, Huttner A, Park HS, Omay SB. Genomic Characterization of Radiation‐Induced Intracranial Undifferentiated Pleomorphic Sarcoma. Case Reports In Genetics 2021, 2021: 5586072. PMID: 33747576, PMCID: PMC7960067, DOI: 10.1155/2021/5586072.Peer-Reviewed Original Research
2020
A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup
Zubair AS, Landreneau M, Witsch J, Fulbright RK, Huttner A, Sheth KN, Hwang DY. A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup. Frontiers In Neurology 2020, 11: 430. PMID: 32595583, PMCID: PMC7304250, DOI: 10.3389/fneur.2020.00430.Peer-Reviewed Case Reports and Technical NotesCentral nervous system TBCentral nervous system tuberculosisEmpiric anti-tuberculous therapyAnti-tuberculous therapyNegative initial workupNervous system tuberculosisStrong clinical suspicionTB meningitisEmpiric treatmentInitial workupClinical suspicionIll patientsTB testingImproved outcomesPatientsPreferred testDiagnostic resultsTBMeningitisGeneXpertTherapyWorkupTuberculosisSuspicionPersistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma
Hong CS, Vasquez JC, Kundishora AJ, Elsamadicy AA, Beckta JM, Sule A, Marks AM, Leelatian N, Huttner A, Bindra RS, DiLuna ML, Kahle KT, Erson-Omay EZ. Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma. Npj Genomic Medicine 2020, 5: 23. PMID: 32528726, PMCID: PMC7264170, DOI: 10.1038/s41525-020-0130-7.Peer-Reviewed Original ResearchPediatric patientsStandard chemoradiationSTAG2 mutationsTumor clonesPediatric glioblastomaGross total resectionMultiple surgical resectionsTime of recurrenceHigh-grade gliomasDNA damage repair defectsWhole-exome sequencingVariety of treatmentsSurgical resectionNovel deleterious mutationsStandard therapyTotal resectionVaccine therapyClinical evidencePreclinical dataTreatment optionsMultimodal therapyPreclinical studiesClinical settingTherapyAdult counterparts
2013
Progressive multifocal leukoencephalopathy in an immunocompetent patient
Christakis PG, Okin D, Huttner AJ, Baehring JM. Progressive multifocal leukoencephalopathy in an immunocompetent patient. Journal Of The Neurological Sciences 2013, 326: 107-110. PMID: 23375959, DOI: 10.1016/j.jns.2013.01.010.Peer-Reviewed Original ResearchConceptsProgressive multifocal leukoencephalopathyImmunocompetent patientsMultifocal leukoencephalopathyTemporal white matterMefloquine therapyOccult immunosuppressionSubacute historyClinical courseExtensive workupPharmacological therapyImmunocompetent individualsCSF PCRSignal abnormalitiesDNA titreSerotonin receptorsBrain MRIAbnormal gaitJC virusOlder menWhite matterLeukoencephalopathyPatientsTherapyImmunosuppressionBiopsy