2023
Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy
Wang Y, Malik S, Suh H, Xiao Y, Deng Y, Fan R, Huttner A, Bindra R, Singh V, Saltzman W, Bahal R. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances 2023, 9: eabq7459. PMID: 36753549, PMCID: PMC9908025, DOI: 10.1126/sciadv.abq7459.Peer-Reviewed Original ResearchConceptsConvection-enhanced deliveryHigh recurrence rateOrthotopic mouse modelBrain tumor therapyTreatment of glioblastomaRecurrence ratePoor survivalLethal malignancyMouse modelGBM progressionTumor cellsGlioblastomaTumor therapyBioadhesive nanoparticlesOncomiRSurvivalTreatmentSeed regionMalignancyTemozolomideTherapy
2021
Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma
Fomchenko EI, Reeves BC, Sullivan W, Marks AM, Huttner A, Kahle KT, Erson‐Omay E. Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma. Molecular Genetics & Genomic Medicine 2021, 9: e1597. PMID: 33448156, PMCID: PMC8077124, DOI: 10.1002/mgg3.1597.Peer-Reviewed Original ResearchConceptsPilomyxoid astrocytomaPediatric patientsVariant allele frequencyHypothalamic/chiasmatic regionPathologic tissue diagnosisTreatment-related morbidityHigh recurrence ratePI3K/mTOR inhibitionYears of ageExome sequencing resultsSimilar time pointsWhole exome sequencing resultsHypothalamic dysfunctionClinical presentationSurgical managementRecurrence rateShorter survivalAggressive subtypeVision lossChiasmatic regionTissue diagnosisPatient tumorsRadiation therapyFGFR inhibitorsFGFR1 mutations
2020
Associations of meningioma molecular subgroup and tumor recurrence
Youngblood MW, Miyagishima DF, Jin L, Gupte T, Li C, Duran D, Montejo JD, Zhao A, Sheth A, Tyrtova E, Özduman K, Iacoangeli F, Peyre M, Boetto J, Pease M, Avşar T, Huttner A, Bilguvar K, Kilic T, Pamir MN, Amankulor N, Kalamarides M, Erson-Omay EZ, Günel M, Moliterno J. Associations of meningioma molecular subgroup and tumor recurrence. Neuro-Oncology 2020, 23: 783-794. PMID: 33068421, PMCID: PMC8099468, DOI: 10.1093/neuonc/noaa226.Peer-Reviewed Original ResearchConceptsDivergent clinical coursesMolecular subgroupsClinical courseClinical outcomesProgression-free survivalExtent of resectionKaplan-Meier analysisLong-term outcomesLow-grade tumorsCox proportional hazardsDistinct clinical outcomesPostoperative radiationIndependent predictorsMale sexRecurrence rateSurveillance imagingTumor recurrencePrevious recurrencesClinical prognosticationKi-67Outcome dataAggressive subgroupRecurrenceElevated recurrenceProportional hazards
2019
HOUT-03. CLINICAL OUTCOMES OF PATIENTS WITH VESTIBULAR SCHWANNOMAS: THE RELEVANCE OF TUMOR SIZE AND RECURRENCE
Zhao A, Fomchenko E, Tyrtova E, Huttner A, Zhang Y, Fulbright R, Erson-Omay E, Jin L, Moliterno J. HOUT-03. CLINICAL OUTCOMES OF PATIENTS WITH VESTIBULAR SCHWANNOMAS: THE RELEVANCE OF TUMOR SIZE AND RECURRENCE. Neuro-Oncology 2019, 21: vi112-vi112. PMCID: PMC6846905, DOI: 10.1093/neuonc/noz175.468.Peer-Reviewed Original ResearchVestibular schwannomaSurgical resectionClinical outcomesTumor sizeLarge tumorsExact testPre-operative tumor sizeSignificant associationProgression-free survival timeMost vestibular schwannomasFacial nerve functionPost-operative complicationsBetter clinical outcomesLow recurrence rateClinical outcome dataBilateral vestibular schwannomasDifferent surgical approachesFisher's exact testSlow growth potentialIntra-tumoral hemorrhageWhole-exome sequencingNerve functionRecurrence rateVS tumorsSurgical approachExtent of resection of epidermoid tumors and risk of recurrence: case report and meta-analysis.
Shear BM, Jin L, Zhang Y, David WB, Fomchenko EI, Erson-Omay EZ, Huttner A, Fulbright RK, Moliterno J. Extent of resection of epidermoid tumors and risk of recurrence: case report and meta-analysis. Journal Of Neurosurgery 2019, 133: 291-301. PMID: 31277071, DOI: 10.3171/2019.4.jns19598.Peer-Reviewed Original ResearchGross total resectionSubtotal resectionRecurrence rateAverage recurrence rateEpidermoid tumorsSafe gross total resectionTransient cranial nerve palsyUnderwent subtotal resectionCranial nerve palsyCommon surgical complicationExtent of resectionRisk of recurrenceTreatment of choiceCritical neurovascular structuresLong-term riskUse of adjunctsIntracranial epidermoid tumorsCubic spline modelsWeb of ScienceNerve palsyRepeat resectionInitial surgeryNatural cubic spline modelSurgical complicationsPooled proportion