2009
An fMRI Study of the Effects of Psychostimulants on Default-Mode Processing During Stroop Task Performance in Youths With ADHD
Peterson BS, Potenza MN, Wang Z, Zhu H, Martin A, Marsh R, Plessen KJ, Yu S. An fMRI Study of the Effects of Psychostimulants on Default-Mode Processing During Stroop Task Performance in Youths With ADHD. American Journal Of Psychiatry 2009, 166: 1286-1294. PMID: 19755575, PMCID: PMC3289412, DOI: 10.1176/appi.ajp.2009.08050724.Peer-Reviewed Original ResearchConceptsVentral anterior cingulate cortexAnterior cingulate cortexEffects of psychostimulantsCingulate cortexComparison subjectsLateral prefrontal cortexPrefrontal cortexStimulant medicationDefault-mode activityFunctional MRI scansPosterior cingulate cortexVentral anterior cingulateDefault mode processingMedicationsMRI scansAnterior cingulateHealthy comparison youthNormal levelsCortexPsychostimulantsGreater activationFMRI studyGreater reductionLateral prefrontalBrain activityPreliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder
KALMAR JH, WANG F, SPENCER L, EDMISTON E, LACADIE CM, MARTIN A, CONSTABLE RT, DUNCAN JS, STAIB LH, PAPADEMETRIS X, BLUMBERG HP. Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder. Journal Of The International Neuropsychological Society 2009, 15: 476-481. PMID: 19402934, PMCID: PMC2852397, DOI: 10.1017/s1355617709090584.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsVentral prefrontal cortexBipolar disorderYoung adultsBrain volume changesRostral anterior cingulate cortexPrevious cross-sectional studiesCross-sectional studyAdolescence/young adulthoodHigh-resolution magnetic resonanceAnterior cingulate cortexPreliminary evidenceVolume abnormalitiesHealthy comparison participantsPrefrontal abnormalitiesGreater volume lossCingulate cortexRegional volumesPrefrontal cortexModest sample sizeYoung adulthoodAdultsRostral PFCComparison participantsAbnormalities
2003
Frontostriatal Abnormalities in Adolescents With Bipolar Disorder: Preliminary Observations From Functional MRI
Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, Fulbright RK, Gore JC, Charney DS, Krystal JH, Peterson BS. Frontostriatal Abnormalities in Adolescents With Bipolar Disorder: Preliminary Observations From Functional MRI. American Journal Of Psychiatry 2003, 160: 1345-1347. PMID: 12832254, DOI: 10.1176/appi.ajp.160.7.1345.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBasal GangliaBipolar DisorderChildFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsPrefrontal CortexConceptsBipolar disorder groupBipolar disorderHealthy groupComparison subjectsDisorder groupNormal comparison subjectsAdult bipolar disorderHealthy comparison subjectsPresence of dysfunctionFunctional magnetic resonance imagingMagnetic resonance imagingBipolar disorder subjectsAge-related increaseEvent-related functional magnetic resonance imagingFrontostriatal abnormalitiesLeft putamenFunctional abnormalitiesPrefrontal abnormalitiesDepressive symptomsResonance imagingVentral striatumFrontostriatal circuitsDisorder subjectsFunctional MRIDevelopmental disturbances
2000
Assessment in Multisite Randomized Clinical Trials of Patients with Autistic Disorder: The Autism RUPP Network
Arnold L, Aman M, Martin A, Collier-Crespin A, Vitiello B, Tierney E, Asarnow R, Bell-Bradshaw F, Freeman B, Gates-Ulanet P, Klin A, McCracken J, McDougle C, McGough J, Posey D, Scahill L, Swiezy N, Ritz L, Vokmar F. Assessment in Multisite Randomized Clinical Trials of Patients with Autistic Disorder: The Autism RUPP Network. Journal Of Autism And Developmental Disorders 2000, 30: 99-111. PMID: 10832774, DOI: 10.1023/a:1005451304303.Peer-Reviewed Original ResearchMeSH KeywordsAntipsychotic AgentsAutistic DisorderChildHumansNeuropsychological TestsReproducibility of ResultsRisperidoneTreatment OutcomeConceptsAutism Diagnostic InterviewChildren/adolescentsAutistic disorders symptomsNeuropsychological testsDisorder symptomsLower functioningAutistic disorderCore featuresTest developersDiagnostic InterviewProblem presentationPediatric psychopharmacologyAutismIndividual changesTreatment respondersTarget symptomsSecondary symptomsCommunication problemsMethodological challengesAssessment strategiesSubject heterogeneityIQPharmacological treatmentDisordersClinical Global Impression