2004
Age Effects on Antidepressant-Induced Manic Conversion
Martin A, Young C, Leckman JF, Mukonoweshuro C, Rosenheck R, Leslie D. Age Effects on Antidepressant-Induced Manic Conversion. JAMA Pediatrics 2004, 158: 773-780. PMID: 15289250, DOI: 10.1001/archpedi.158.8.773.Peer-Reviewed Original ResearchConceptsManic conversionAntidepressant classesPatient ageTime-dependent Cox proportional hazards modelsSelective serotonin reuptake inhibitorsCox proportional hazards modelNonbipolar mood disorderSerotonin reuptake inhibitorsProportional hazards modelRisk of conversionAdministrative national databaseEffect of agePharmacy claimsReuptake inhibitorsAntidepressant exposureDrug therapyTricyclic antidepressantsPeripubertal childrenAge effectsBipolar illnessMood disordersHigh riskMental health usersAntidepressant categoryHazards model
2001
Are child-, adolescent-, and adult-onset depression one and the same disorder?
Kaufman J, Martin A, King R, Charney D. Are child-, adolescent-, and adult-onset depression one and the same disorder? Biological Psychiatry 2001, 49: 980-1001. PMID: 11430841, DOI: 10.1016/s0006-3223(01)01127-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-Inflammatory AgentsAntidepressive Agents, TricyclicBrainChildCorticotropin-Releasing HormoneDepressive Disorder, MajorDexamethasoneDiagnosis, DifferentialGrowth Hormone-Releasing HormoneHumansHydrocortisoneImmunity, CellularMagnetic Resonance ImagingSerotoninThyroid HormonesConceptsAdult-onset depressionBasal cortisol secretionStage of illnessSerotonergic probeTricyclic medicationDepressed cohortClinical outcomesCortisol secretionHormone infusionIllness factorsTreatment responsePreclinical studiesSame disorderDepressed adultsImmunity indicesDepression oneFamilial subtypeNeurobiological assessmentNeurobiological correlatesChildrenAdolescentsIllnessDiscrepant findingsNeuroimaging paradigmDepression