2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder
Johnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderWhite matter integrityFunctional connectivityMatter volumeSuicide attemptsAttempt lethalityPrefrontal connectivitySuicidal ideationYoung adult suicide attemptersAmygdala-prefrontal functional connectivityYoung adultsAmygdala functional connectivitySuicide-related symptomsAdult suicide attemptersPrior suicide attemptsRegional gray matter volumeFrontolimbic structuresNonattempter groupFrontolimbic systemsHigh riskSignificant negative correlationFunctional MROrbitofrontal cortexSuicidal behavior
2009
An fMRI Study of the Effects of Psychostimulants on Default-Mode Processing During Stroop Task Performance in Youths With ADHD
Peterson BS, Potenza MN, Wang Z, Zhu H, Martin A, Marsh R, Plessen KJ, Yu S. An fMRI Study of the Effects of Psychostimulants on Default-Mode Processing During Stroop Task Performance in Youths With ADHD. American Journal Of Psychiatry 2009, 166: 1286-1294. PMID: 19755575, PMCID: PMC3289412, DOI: 10.1176/appi.ajp.2009.08050724.Peer-Reviewed Original ResearchConceptsVentral anterior cingulate cortexAnterior cingulate cortexEffects of psychostimulantsCingulate cortexComparison subjectsLateral prefrontal cortexPrefrontal cortexStimulant medicationDefault-mode activityFunctional MRI scansPosterior cingulate cortexVentral anterior cingulateDefault mode processingMedicationsMRI scansAnterior cingulateHealthy comparison youthNormal levelsCortexPsychostimulantsGreater activationFMRI studyGreater reductionLateral prefrontalBrain activityRelation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder
Kalmar JH, Wang F, Chepenik LG, Womer FY, Jones MM, Pittman B, Shah MP, Martin A, Constable RT, Blumberg HP. Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 636-642. PMID: 19454919, PMCID: PMC2867040, DOI: 10.1097/chi.0b013e31819f6fbc.Peer-Reviewed Original ResearchConceptsAmygdala volumeBipolar disorderInverse associationAmygdala structureMagnetic resonance imaging (MRI) scansAmygdala responseFunctional magnetic resonance imaging (fMRI) scansResonance imaging scansPossible pathophysiological linkSignificant inverse associationSmaller amygdala volumesFunctional magnetic resonancePathophysiological linkImaging scansBD groupHighest amygdala responseEmotional stimuliBD participantsElevated responseNeuroimaging sessionAdolescentsAmygdalaPrevious reportsPreliminary findingsDisordersPreliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder
KALMAR JH, WANG F, SPENCER L, EDMISTON E, LACADIE CM, MARTIN A, CONSTABLE RT, DUNCAN JS, STAIB LH, PAPADEMETRIS X, BLUMBERG HP. Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder. Journal Of The International Neuropsychological Society 2009, 15: 476-481. PMID: 19402934, PMCID: PMC2852397, DOI: 10.1017/s1355617709090584.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsVentral prefrontal cortexBipolar disorderYoung adultsBrain volume changesRostral anterior cingulate cortexPrevious cross-sectional studiesCross-sectional studyAdolescence/young adulthoodHigh-resolution magnetic resonanceAnterior cingulate cortexPreliminary evidenceVolume abnormalitiesHealthy comparison participantsPrefrontal abnormalitiesGreater volume lossCingulate cortexRegional volumesPrefrontal cortexModest sample sizeYoung adulthoodAdultsRostral PFCComparison participantsAbnormalities
2006
Neurobiology of Depression in Children and Adolescents
Zalsman G, Oquendo MA, Greenhill L, Goldberg PH, Kamali M, Martin A, Mann JJ. Neurobiology of Depression in Children and Adolescents. Child And Adolescent Psychiatric Clinics Of North America 2006, 15: 843-868. PMID: 16952764, DOI: 10.1016/j.chc.2006.05.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenocorticotropic HormoneAnxiety DisordersBrainChildCognitive Behavioral TherapyCorticotropin-Releasing HormoneDepressive DisorderEstradiolFemaleHuman Growth HormoneHumansHypothalamo-Hypophyseal SystemMagnetic Resonance ImagingMaleNeurotransmitter AgentsPituitary-Adrenal SystemPrevalencePubertyRisk FactorsTestosteroneAge, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study
Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDrug TherapyFemaleHumansMagnetic Resonance ImagingMalePeriodicityPrefrontal CortexConceptsHealthy comparison subjectsWhite matter volumeMagnetic resonance imagingMatter volumeBD patientsHigh-resolution structural magnetic resonance imagingYoung adulthoodStructural magnetic resonance imagingTotal brain volumeCross-sectional studyGray matter volumeAge group interactionVentral prefrontal cortexPharmacotherapy effectsPrefrontal cortex functionIllness featuresBD IProtective effectVolume abnormalitiesHC subjectsComparison subjectsBrain volumeVolume deficitsBipolar disorderRapid initial decline
2005
Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder
Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders 2005, 7: 570-576. PMID: 16403182, PMCID: PMC2291299, DOI: 10.1111/j.1399-5618.2005.00264.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmygdalaBipolar DisorderCase-Control StudiesFemaleHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleConceptsAmygdala volumeBipolar disorderYoung adultsAmygdala volume abnormalitiesTotal brain volumeHigh-resolution magnetic resonancePreliminary evidenceSubjects longitudinal designPersistent abnormalitiesMixed-model statistical analysisBD IVolume abnormalitiesHealthy comparison participantsBrain volumeHealthy participantsAbnormalitiesAdultsAdolescentsComparison participantsAmygdalaDevelopmental epochsDisordersLongitudinal designParticipantsMagnetic resonance
2004
Significance of Adolescent Neurodevelopment for the Neural Circuitry of Bipolar Disorder
BLUMBERG HP, KAUFMAN J, MARTIN A, CHARNEY DS, KRYSTAL JH, PETERSON BS. Significance of Adolescent Neurodevelopment for the Neural Circuitry of Bipolar Disorder. Annals Of The New York Academy Of Sciences 2004, 1021: 376-383. PMID: 15251913, DOI: 10.1196/annals.1308.048.Peer-Reviewed Original ResearchConceptsNeural systemsCourse of adolescenceMajor developmental changesExecutive controlAdolescent neurodevelopmentEarly adolescenceLate adolescenceDevelopmental epochsNeural circuitryNeurodevelopmental modelDevelopmental changesEarly adulthoodAdolescenceSubcortical componentsBipolar disorderDeficitsImportant implicationsEmotionsVPFCDisordersAmygdalaEarly signsAdulthoodTreatment strategiesParticular components
2003
Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder
Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder. JAMA Psychiatry 2003, 60: 1201-1208. PMID: 14662552, DOI: 10.1001/archpsyc.60.12.1201.Peer-Reviewed Original ResearchConceptsHippocampal volumeMedial temporal lobe structuresTemporal lobe structuresBipolar disorderIllness featuresVeterans Affairs Medical CenterLobe structuresRepeated-measures statistical analysisCourse of illnessTotal brain volumeAmygdala volume reductionsBD type IAnatomic magnetic resonanceHealthy comparison subjectsPaucity of dataVolume reductionSignificant volume reductionVolumetric abnormalitiesNeurodegenerative changesIllness durationOutpatient treatmentUniversity HospitalGreater effect sizeMedical CenterHippocampal regionFrontostriatal Abnormalities in Adolescents With Bipolar Disorder: Preliminary Observations From Functional MRI
Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, Fulbright RK, Gore JC, Charney DS, Krystal JH, Peterson BS. Frontostriatal Abnormalities in Adolescents With Bipolar Disorder: Preliminary Observations From Functional MRI. American Journal Of Psychiatry 2003, 160: 1345-1347. PMID: 12832254, DOI: 10.1176/appi.ajp.160.7.1345.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBasal GangliaBipolar DisorderChildFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsPrefrontal CortexConceptsBipolar disorder groupBipolar disorderHealthy groupComparison subjectsDisorder groupNormal comparison subjectsAdult bipolar disorderHealthy comparison subjectsPresence of dysfunctionFunctional magnetic resonance imagingMagnetic resonance imagingBipolar disorder subjectsAge-related increaseEvent-related functional magnetic resonance imagingFrontostriatal abnormalitiesLeft putamenFunctional abnormalitiesPrefrontal abnormalitiesDepressive symptomsResonance imagingVentral striatumFrontostriatal circuitsDisorder subjectsFunctional MRIDevelopmental disturbances
2001
Are child-, adolescent-, and adult-onset depression one and the same disorder?
Kaufman J, Martin A, King R, Charney D. Are child-, adolescent-, and adult-onset depression one and the same disorder? Biological Psychiatry 2001, 49: 980-1001. PMID: 11430841, DOI: 10.1016/s0006-3223(01)01127-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-Inflammatory AgentsAntidepressive Agents, TricyclicBrainChildCorticotropin-Releasing HormoneDepressive Disorder, MajorDexamethasoneDiagnosis, DifferentialGrowth Hormone-Releasing HormoneHumansHydrocortisoneImmunity, CellularMagnetic Resonance ImagingSerotoninThyroid HormonesConceptsAdult-onset depressionBasal cortisol secretionStage of illnessSerotonergic probeTricyclic medicationDepressed cohortClinical outcomesCortisol secretionHormone infusionIllness factorsTreatment responsePreclinical studiesSame disorderDepressed adultsImmunity indicesDepression oneFamilial subtypeNeurobiological assessmentNeurobiological correlatesChildrenAdolescentsIllnessDiscrepant findingsNeuroimaging paradigmDepression