2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder
Johnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderWhite matter integrityFunctional connectivityMatter volumeSuicide attemptsAttempt lethalityPrefrontal connectivitySuicidal ideationYoung adult suicide attemptersAmygdala-prefrontal functional connectivityYoung adultsAmygdala functional connectivitySuicide-related symptomsAdult suicide attemptersPrior suicide attemptsRegional gray matter volumeFrontolimbic structuresNonattempter groupFrontolimbic systemsHigh riskSignificant negative correlationFunctional MROrbitofrontal cortexSuicidal behavior
2009
Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder
Kalmar JH, Wang F, Chepenik LG, Womer FY, Jones MM, Pittman B, Shah MP, Martin A, Constable RT, Blumberg HP. Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 636-642. PMID: 19454919, PMCID: PMC2867040, DOI: 10.1097/chi.0b013e31819f6fbc.Peer-Reviewed Original ResearchConceptsAmygdala volumeBipolar disorderInverse associationAmygdala structureMagnetic resonance imaging (MRI) scansAmygdala responseFunctional magnetic resonance imaging (fMRI) scansResonance imaging scansPossible pathophysiological linkSignificant inverse associationSmaller amygdala volumesFunctional magnetic resonancePathophysiological linkImaging scansBD groupHighest amygdala responseEmotional stimuliBD participantsElevated responseNeuroimaging sessionAdolescentsAmygdalaPrevious reportsPreliminary findingsDisorders