2010
Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis
Reyes MM, Panza KE, Martin A, Bloch MH. Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 63-72. PMID: 21156271, PMCID: PMC3645909, DOI: 10.1016/j.jaac.2010.10.008.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsPlacebo-controlled trialTime-lag biasMajor depressive disorderYears of ageReuptake inhibitorsAntidepressant trialsPediatric depressionDepressive disorderTreatment respondersMAIN OUTCOMESystematic reviewMeta-AnalysisPositive findingsNegative findingsNegative trialsMedical literatureAntidepressantsTrialsPublication of findingsNegative resultsChild psychiatryEfficacyFindingsPublication time
2006
Selective Serotonin Reuptake Inhibitors and Suicidality in Juveniles: Review of the Evidence and Implications for Clinical Practice
Rey JM, Martin A. Selective Serotonin Reuptake Inhibitors and Suicidality in Juveniles: Review of the Evidence and Implications for Clinical Practice. Child And Adolescent Psychiatric Clinics Of North America 2006, 15: 221-237. PMID: 16321732, DOI: 10.1016/j.chc.2005.08.012.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsReuptake inhibitorsClinical practiceCareful clinical monitoringPharmacologic treatmentMedication complianceManic switchingSevere depressionClinical monitoringSuicidal behaviorBehavioral activationSuicidalityPersonal sufferingDepressionInhibitorsEvidenceNontreatment
2005
Antidepressant‐Induced Manic Conversion: A Developmentally Informed Synthesis of the Literature
Lim CJ, Leckman JF, Young C, Martin A. Antidepressant‐Induced Manic Conversion: A Developmentally Informed Synthesis of the Literature. International Review Of Neurobiology 2005, 65: 25-52. PMID: 16140052, DOI: 10.1016/s0074-7742(04)65002-1.Peer-Reviewed Original ResearchConceptsAddition of antidepressantsResolution of symptomsAntidepressant-induced maniaSerotonin reuptake inhibitorsMood stabilizer therapyLess nursing careMost case reportsRapid cyclingManic conversionSpontaneous maniaAntidepressant medicationReuptake inhibitorsAntidepressant exposureBipolar depressionCase reportManic episodesMood destabilizationSpontaneous episodesDistressing conditionSevere depressionClinical recommendationsManic symptomsNursing careSelective SSRIPatient screening
2004
Age Effects on Antidepressant-Induced Manic Conversion
Martin A, Young C, Leckman JF, Mukonoweshuro C, Rosenheck R, Leslie D. Age Effects on Antidepressant-Induced Manic Conversion. JAMA Pediatrics 2004, 158: 773-780. PMID: 15289250, DOI: 10.1001/archpedi.158.8.773.Peer-Reviewed Original ResearchConceptsManic conversionAntidepressant classesPatient ageTime-dependent Cox proportional hazards modelsSelective serotonin reuptake inhibitorsCox proportional hazards modelNonbipolar mood disorderSerotonin reuptake inhibitorsProportional hazards modelRisk of conversionAdministrative national databaseEffect of agePharmacy claimsReuptake inhibitorsAntidepressant exposureDrug therapyTricyclic antidepressantsPeripubertal childrenAge effectsBipolar illnessMood disordersHigh riskMental health usersAntidepressant categoryHazards model
2003
Which SSRI? A Meta-Analysis of Pharmacotherapy Trials in Pediatric Obsessive-Compulsive Disorder
Geller DA, Biederman J, Stewart SE, Mullin B, Martin A, Spencer T, Faraone SV. Which SSRI? A Meta-Analysis of Pharmacotherapy Trials in Pediatric Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2003, 160: 1919-1928. PMID: 14594734, DOI: 10.1176/appi.ajp.160.11.1919.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsObsessive-compulsive disorderStandardized mean differenceOutcome measuresMean differenceStudy designSerotonin reuptake inhibitorsDependent outcome measuresAdolescent obsessive-compulsive disorderSystematic literature searchMultivariate regression analysisPediatric obsessive-compulsive disorderTypes of drugsEffect sizePlacebo treatmentMedication trialsReuptake inhibitorsOutcome scoresPharmacological treatmentPharmacotherapy trialsOverall effect sizeInclusion criteriaClinical careDrug effectsMeta-AnalysisTrends in Psychotropic Medication Costs for Children and Adolescents, 1997-2000
Martin A, Leslie D. Trends in Psychotropic Medication Costs for Children and Adolescents, 1997-2000. JAMA Pediatrics 2003, 157: 997-1004. PMID: 14557161, DOI: 10.1001/archpedi.157.10.997.Peer-Reviewed Original ResearchConceptsCostly medicationsSelective serotonin reuptake inhibitorsPsychotropic medication costsPsychotropic medication utilizationSerotonin reuptake inhibitorsWarrants further studyMental health outpatientsMedication utilizationAtypical antidepressantsAtypical antipsychoticsPharmacy claimsReuptake inhibitorsMedication costsPsychotropic drugsDrug categoriesMedicationsNational databaseDrugsOverall useFurther studiesChildrenPrescription pricesAntipsychoticsAntidepressantsOutpatients