2010
Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis
Reyes MM, Panza KE, Martin A, Bloch MH. Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 63-72. PMID: 21156271, PMCID: PMC3645909, DOI: 10.1016/j.jaac.2010.10.008.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsPlacebo-controlled trialTime-lag biasMajor depressive disorderYears of ageReuptake inhibitorsAntidepressant trialsPediatric depressionDepressive disorderTreatment respondersMAIN OUTCOMESystematic reviewMeta-AnalysisPositive findingsNegative findingsNegative trialsMedical literatureAntidepressantsTrialsPublication of findingsNegative resultsChild psychiatryEfficacyFindingsPublication timeCharacterizing Declines in Pediatric Antidepressant Use After New Risk Disclosures
Busch SH, Frank RG, Martin A, Barry CL. Characterizing Declines in Pediatric Antidepressant Use After New Risk Disclosures. Medical Care Research And Review 2010, 68: 96-111. PMID: 20675349, PMCID: PMC2974787, DOI: 10.1177/1077558710374197.Peer-Reviewed Original ResearchConceptsAntidepressant usePediatric antidepressant useAntidepressant medication useNew treatment episodeNew safety informationRisk of suicidalityAntidepressant medicationMedication useTreatment patternsTreatment episodesHealth outcomesLatter groupChildrenSafety informationFamily characteristicsCollege-educated parentsExperienced declinesMedicationsAntidepressantsDeclineFindingsSuicidalityAntidepressants and suicide risk: how did specific information in FDA safety warnings affect treatment patterns?
Busch SH, Frank RG, Leslie DL, Martin A, Rosenheck RA, Martin EG, Barry CL. Antidepressants and suicide risk: how did specific information in FDA safety warnings affect treatment patterns? Psychiatric Services 2010, 61: 11-6. PMID: 20044412, PMCID: PMC2801076, DOI: 10.1176/appi.ps.61.1.11.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAntidepressant useTreatment patternsDepressive disorderFDA safety warningsSpecific safety informationThomson Reuters MarketScanUse of paroxetineRisk of suicidalitySafety warningsAntidepressant treatmentOutpatient visitsTreatment episodesTreatment recommendationsPractice patternsNew episodesDrug AdministrationSuicide riskFDA recommendationsDepressed childrenU.S. FoodFDAAntidepressantsChildrenEvidence of increases
2003
Trends in Psychotropic Medication Costs for Children and Adolescents, 1997-2000
Martin A, Leslie D. Trends in Psychotropic Medication Costs for Children and Adolescents, 1997-2000. JAMA Pediatrics 2003, 157: 997-1004. PMID: 14557161, DOI: 10.1001/archpedi.157.10.997.Peer-Reviewed Original ResearchConceptsCostly medicationsSelective serotonin reuptake inhibitorsPsychotropic medication costsPsychotropic medication utilizationSerotonin reuptake inhibitorsWarrants further studyMental health outpatientsMedication utilizationAtypical antidepressantsAtypical antipsychoticsPharmacy claimsReuptake inhibitorsMedication costsPsychotropic drugsDrug categoriesMedicationsNational databaseDrugsOverall useFurther studiesChildrenPrescription pricesAntipsychoticsAntidepressantsOutpatients
1999
Higher-Functioning Pervasive Developmental Disorders: Rates and Patterns of Psychotropic Drug Use
MARTIN A, SCAHILL L, KLIN A, VOLKMAR F. Higher-Functioning Pervasive Developmental Disorders: Rates and Patterns of Psychotropic Drug Use. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 923-931. PMID: 10405512, DOI: 10.1097/00004583-199907000-00024.Peer-Reviewed Original ResearchConceptsPsychotropic drug useHigher-functioning pervasive developmental disordersPervasive developmental disorderTarget symptomsDrug useMedication use patternsPsychotropic medication useDevelopmental disordersMedication history informationMore medicationsMedication useClinical presentationPsychiatric comorbidityClinical variablesPsychotropic agentsDrug classesClinical heterogeneityDisordersSymptomsSubjectsAsperger's disorderFull Scale IQComorbiditiesMedicationsAntidepressants