2009
Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder
Kalmar JH, Wang F, Chepenik LG, Womer FY, Jones MM, Pittman B, Shah MP, Martin A, Constable RT, Blumberg HP. Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 636-642. PMID: 19454919, PMCID: PMC2867040, DOI: 10.1097/chi.0b013e31819f6fbc.Peer-Reviewed Original ResearchConceptsAmygdala volumeBipolar disorderInverse associationAmygdala structureMagnetic resonance imaging (MRI) scansAmygdala responseFunctional magnetic resonance imaging (fMRI) scansResonance imaging scansPossible pathophysiological linkSignificant inverse associationSmaller amygdala volumesFunctional magnetic resonancePathophysiological linkImaging scansBD groupHighest amygdala responseEmotional stimuliBD participantsElevated responseNeuroimaging sessionAdolescentsAmygdalaPrevious reportsPreliminary findingsDisorders
2005
Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder
Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders 2005, 7: 570-576. PMID: 16403182, PMCID: PMC2291299, DOI: 10.1111/j.1399-5618.2005.00264.x.Peer-Reviewed Original ResearchConceptsAmygdala volumeBipolar disorderYoung adultsAmygdala volume abnormalitiesTotal brain volumeHigh-resolution magnetic resonancePreliminary evidenceSubjects longitudinal designPersistent abnormalitiesMixed-model statistical analysisBD IVolume abnormalitiesHealthy comparison participantsBrain volumeHealthy participantsAbnormalitiesAdultsAdolescentsComparison participantsAmygdalaDevelopmental epochsDisordersLongitudinal designParticipantsMagnetic resonance
2004
Significance of Adolescent Neurodevelopment for the Neural Circuitry of Bipolar Disorder
BLUMBERG HP, KAUFMAN J, MARTIN A, CHARNEY DS, KRYSTAL JH, PETERSON BS. Significance of Adolescent Neurodevelopment for the Neural Circuitry of Bipolar Disorder. Annals Of The New York Academy Of Sciences 2004, 1021: 376-383. PMID: 15251913, DOI: 10.1196/annals.1308.048.Peer-Reviewed Original ResearchConceptsNeural systemsCourse of adolescenceMajor developmental changesExecutive controlAdolescent neurodevelopmentEarly adolescenceLate adolescenceDevelopmental epochsNeural circuitryNeurodevelopmental modelDevelopmental changesEarly adulthoodAdolescenceSubcortical componentsBipolar disorderDeficitsImportant implicationsEmotionsVPFCDisordersAmygdalaEarly signsAdulthoodTreatment strategiesParticular components