2004
Favorable effect of γ‐radiation for in‐stent restenosis: Effect of diabetes on angiographic and clinical outcomes
Iakovou I, Mehran R, Dangas G, Lansky AJ, Stone GW, Mintz GS, Aymong E, Ashby DT, Pichard AD, Satler LF, Kent K, Leon MB, Waksman R. Favorable effect of γ‐radiation for in‐stent restenosis: Effect of diabetes on angiographic and clinical outcomes. Catheterization And Cardiovascular Interventions 2004, 62: 303-307. PMID: 15224295, DOI: 10.1002/ccd.20070.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationDiabetes mellitusStent restenosisMajor adverse cardiac event ratesAdverse cardiac event ratesIn-Stent Restenosis TrialLower target lesion revascularizationMajor adverse cardiac eventsNon-DM patientsAdverse cardiac eventsCardiac event rateTreatment of ISREffect of diabetesSimilar procedural successGamma radiation therapyLesion revascularizationHospital outcomesRestenosis TrialVessel revascularizationCardiac eventsProcedural successClinical outcomesWashington RadiationVascular brachytherapyPatientsGamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes
Mehran R, Iakovou I, Dangas G, Lansky AJ, Stone GW, Mintz GS, Kent KM, Pichard AD, Satler LF, Fahy M, Leon MB, Waksman R. Gamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes. Catheterization And Cardiovascular Interventions 2004, 61: 354-359. PMID: 14988895, DOI: 10.1002/ccd.10786.Peer-Reviewed Original ResearchConceptsISR groupLesion lengthClinical eventsIn-Stent Restenosis TrialBaseline lesion lengthLower late lossShort lesion groupTreatment of ISRStent restenosis lesionsLong-term outcomesRecurrent ISRRestenosis lesionsRestenosis TrialAngiographic outcomesISR lesionsRestenosis rateClinical outcomesWashington RadiationLate lossStent restenosisLumen dimensionsLong ISRRadiation treatmentPowerful predictorPatients
2002
Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis
Prpic R, Teirstein PS, Reilly JP, Moses JW, Tripuraneni P, Lansky AJ, Giorgianni JA, Jani S, Wong SC, Fish RD, Ellis S, Holmes DR, Kereiakas D, Kuntz RE, Leon MB. Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis. Circulation 2002, 106: 2340-2345. PMID: 12403664, DOI: 10.1161/01.cir.0000036366.62288.74.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationIndex treatmentIntracoronary brachytherapyPercutaneous interventionStent restenosisAcceptable long-term resultsMajor adverse event rateRepeat percutaneous coronary interventionRepeat target vessel revascularizationSubsequent target lesion revascularizationTarget vessel revascularizationAcute procedural successAdverse event ratesPercutaneous coronary interventionIntracoronary radiation therapyLong-term outcomesLong-term resultsIn-Stent RestenosisLesion revascularizationPlacebo groupCoronary interventionFailure patientsProcedural successAngioplasty/Term outcomesLate Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation
Morino Y, Limpijankit T, Honda Y, Lansky AJ, Waksman R, Bonneau HN, Yock PG, Mintz GS, Fitzgerald PJ. Late Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation. Circulation 2002, 105: 2465-2468. PMID: 12034650, DOI: 10.1161/01.cir.0000018949.39445.40.Peer-Reviewed Original ResearchMeSH KeywordsBlood Vessel Prosthesis ImplantationBrachytherapyCohort StudiesCoronary RestenosisDisease ProgressionDouble-Blind MethodFollow-Up StudiesGamma RaysHumansIridium RadioisotopesPlatelet Aggregation InhibitorsRandomized Controlled Trials as TopicRecurrenceReoperationStentsTiclopidineTimeTreatment OutcomeUltrasonography, InterventionalVascular PatencyConceptsLumen volume indexISR lesionsPlacebo patientsLate vascular responseAcute angiographic resultsIntravascular ultrasound analysisIn-Stent RestenosisPlacebo groupAngiographic resultsVascular responsesAdditional lumenNeointimal proliferationStent restenosisIrradiated groupPatientsStent overlapLesionsVolume indexUltrasound analysisSafety of radiationLong-term advantagesStent strutsSignificant decreaseStentingRestenosisFive-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy
Condado JA, Waksman R, Saucedo JF, Bhargava B, Lansky AJ, Calderas C, Gurdiel O, Gonzalez J, Fadoul M, Parra B, Iturria I, Amezaga B. Five-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy. Cardiovascular Revascularization Medicine 2002, 3: 74-81. PMID: 12699836, DOI: 10.1016/s1522-1865(03)00077-5.Peer-Reviewed Original ResearchConceptsQuantitative coronary analysisIntracoronary gamma radiationBalloon angioplastyRadiation therapyAngiographic complicationsStandard balloon angioplastyBinary restenosis rateIntracoronary radiation therapyIncidence of restenosisNew adverse effectsPrevention of restenosisLesion revascularizationUnstable anginaAngioplasty siteRestenosis rateNontarget vesselsTotal occlusionMyocardial infarctionAngiographic effectsClinical trialsAneurysm formationLate lossNeointimal formationLong-term effectsPatientsQuantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation
Lansky AJ, Dangas G, Mehran R, Desai KJ, Stone G, Leon M, Mintz G, Waksman R, Wu H, Fahy M. Quantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation. Journal Of The American College Of Cardiology 2002, 39: 274-280. PMID: 11788219, DOI: 10.1016/s0735-1097(01)01745-4.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationRecurrent restenosisDiameter stenosisReceiver operator curveStent restenosisIn-Stent Restenosis TrialIntracoronary radiation therapyPercent diameter stenosisQuantitative coronary angiographyQuantitative angiographic methodsAngiographic locationBlinded therapyRestenosis TrialVessel revascularizationClinical restenosisCoronary angiographyRestenosis rateRestenotic lesionsTreatment failureWashington RadiationBrachytherapy trialsInterventional treatmentVascular brachytherapyEnd-point analysisRadiation therapyDevice selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials)
Ajani AE, Waksman R, Zimarino M, Kim H, Pichard AD, Satler LF, Kent KM, White RL, Pinnow E, Mehran R, Lansky A, Lindsay J. Device selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials). The American Journal Of Cardiology 2002, 89: 137-144. PMID: 11792331, DOI: 10.1016/s0002-9149(01)02189-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplastyAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary DiseaseDose-Response Relationship, RadiationFemaleHumansIridium RadioisotopesLogistic ModelsMaleMiddle AgedProspective StudiesRisk FactorsSecondary PreventionStentsTreatment OutcomeVascular PatencyConceptsExcimer laser coronary angioplastyMajor adverse coronary eventsAdditional stent implantationTreatment of ISRRecurrence rateCoronary angioplastyRotational atherectomyStent implantationStent restenosisBalloon percutaneous transluminal coronary angioplastyPercutaneous transluminal coronary angioplastyIntracoronary gamma radiationLate clinical outcomesAdverse coronary eventsOverall recurrence rateTransluminal coronary angioplastyLaser coronary angioplastyHigh recurrence rateUse of stentingDevice selectionAngiographic characteristicsMACE ratePlacebo groupPlacebo therapyCoronary events
2001
Serial intravascular ultrasound analysis of edge recurrence after intracoronary gamma radiation treatment of native artery in-stent restenosis lesions
Ahmed J, Mintz G, Waksman R, Lansky A, Mehran R, Wu H, Weissman N, Pichard A, Satler L, Kent K, Leon M. Serial intravascular ultrasound analysis of edge recurrence after intracoronary gamma radiation treatment of native artery in-stent restenosis lesions. The American Journal Of Cardiology 2001, 87: 1145-1149. PMID: 11356387, DOI: 10.1016/s0002-9149(01)01483-7.Peer-Reviewed Original ResearchMeSH KeywordsBrachytherapyCoronary AngiographyCoronary DiseaseCoronary VesselsHumansIridium RadioisotopesRecurrenceStentsUltrasonography, InterventionalConceptsLumen cross-sectional areaIntimal hyperplasia cross-sectional areaSerial intravascular ultrasound analysisMedia cross-sectional areaEdge recurrenceIntravascular ultrasound analysisCross-sectional areaStent restenosisExternal elastic membrane cross-sectional areaUltrasound analysisStent restenosis TrialStent restenosis lesionsDistal cross-sectional areasGreater decreaseGreater increaseRestenosis lesionsRestenosis TrialPositive remodelingProximal plaqueWashington RadiationNative coronariesMean lumenNeointimal hyperplasiaRecurrenceLesionsIntracoronary radiation with gamma wire inhibits recurrent in-stent restenosis
Waksman R, Bhargava B, Chan R, Sherman W, Pisch J, Mintz G, Lansky A, Ahmed J, Ricci N, Liprie S. Intracoronary radiation with gamma wire inhibits recurrent in-stent restenosis. Cardiovascular Revascularization Medicine 2001, 2: 63-68. PMID: 11340009, DOI: 10.1016/s1522-1865(00)00086-x.Peer-Reviewed Original ResearchConceptsIntracoronary gamma radiationTarget lesion revascularizationStent restenosisMyocardial infractionBaseline lesion lengthUnderwent bypass surgeryBinary restenosis rateEvent-free survivalNeointimal tissue proliferationInitial clinical trialsStent restenosis resultsSource wireLesion revascularizationRepeat PTCAAngiographic restenosisPrimary endpointRepeat revascularizationSecondary endpointsBypass surgeryRestenosis rateIntracoronary radiationProcedural successTherapeutic challengeClinical trialsNeointimal hyperplasiaLocalized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting
Leon M, Teirstein P, Moses J, Tripuraneni P, Lansky A, Jani S, Wong S, Fish D, Ellis S, Holmes D, Kerieakes D, Kuntz R. Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting. New England Journal Of Medicine 2001, 344: 250-256. PMID: 11172151, DOI: 10.1056/nejm200101253440402.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryBrachytherapyCombined Modality TherapyCoronary DiseaseCoronary ThrombosisDose-Response Relationship, RadiationDouble-Blind MethodFemaleGamma RaysHumansIridium RadioisotopesMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPlatelet Aggregation InhibitorsRadiotherapy DosageSecondary PreventionStentsConceptsIridium-192 groupMyocardial infarctionLate thrombosisStent restenosisIridium-192Intracoronary irradiationTarget lesionsIntracoronary gamma radiation therapyMajor adverse cardiac eventsFrequency of restenosisOral antiplatelet therapyAdverse cardiac eventsComposite of deathPrimary end pointLate myocardial infarctionIntracoronary radiation therapyIncidence of deathRecurrence of restenosisGamma radiation therapyEligible patientsAngiographic restenosisAntiplatelet therapyPlacebo groupCardiac eventsCoronary angioplasty
2000
Serial volumetric intravascular ultrasound analysis of the efficacy of beta irradiation in preventing recurrent in-stent restenosis
Bhargava B, Mintz G, Mehran R, Lansky A, Weissman N, Walsh C, Chan R, Waksman R. Serial volumetric intravascular ultrasound analysis of the efficacy of beta irradiation in preventing recurrent in-stent restenosis. The American Journal Of Cardiology 2000, 85: 651-653. PMID: 11078283, DOI: 10.1016/s0002-9149(99)00827-9.Peer-Reviewed Original ResearchConceptsRestenosis TrialWashington RadiationVolumetric intravascular ultrasound analysisIntimal hyperplasia volumeSerial Volumetric Intravascular Ultrasound AnalysisIntravascular ultrasound findingsIntravascular ultrasound analysisUltrasound findingsStent restenosisPlaceboUltrasound analysisLumen volumePatientsTrialsBetaGammaBeta irradiationRestenosisPostinterventionRecurrent
1999
Intracoronary radiation for patients with refractory in-stent restenosis An analysis from the wrist-crossover trial
Waksman R, Bhargava B, White R, Chan R, Gierlach L, Mehran R, Lansky A, Kent K, Mintz G, Satler L, Pichard A, Leon M. Intracoronary radiation for patients with refractory in-stent restenosis An analysis from the wrist-crossover trial. Cardiovascular Revascularization Medicine 1999, 1: 317-322. PMID: 10828560, DOI: 10.1016/s1522-1865(00)00024-x.Peer-Reviewed Original ResearchConceptsPrimary treatment groupTarget lesion revascularizationCrossover groupStent restenosisTreatment groupsClinical trialsQ-wave myocardial infarctionStent restenosis TrialAdverse cardiac eventsPrimary clinical endpointIntracoronary stent implantationRandomized clinical trialsCatheter-based interventionsCatheter-based techniquesStent neointimal formationAnginal symptomsLesion revascularizationRecurrent ISRRestenosis TrialActive therapyAngiographic outcomesCardiac eventsPlacebo armProcedural successIntracoronary radiationQuantitative angiographic analysis of stent restenosis in the scripps coronary radiation to inhibit intimal proliferation post stenting (SCRIPPS) trial
Lansky A, Popma J, Massullo V, Jani S, Russo R, Schatz R, Steuterman S, Guarneri E, Wu H, Mehran R, Mintz G, Leon M, Teirstein P. Quantitative angiographic analysis of stent restenosis in the scripps coronary radiation to inhibit intimal proliferation post stenting (SCRIPPS) trial. The American Journal Of Cardiology 1999, 84: 410-414. PMID: 10468078, DOI: 10.1016/s0002-9149(99)00325-2.Peer-Reviewed Original ResearchConceptsStent marginsStenting TrialStent restenosisIr-192Quantitative angiographic resultsQuantitative angiographic analysisLower restenosis ratePercent diameter stenosisLower relative riskPlacebo sourcesAngiographic resultsRestenosis rateDiameter stenosisAngiographic analysisRelative riskRestenosisTreatment lengthIridium-192Successful interventionsTrialsFurther studiesPatientsTreatmentStenosisFollowImages in cardiovascular radiation medicine. Edge restenosis post gamma radiation.
Waksman R, Lansky AJ. Images in cardiovascular radiation medicine. Edge restenosis post gamma radiation. Cardiovascular Revascularization Medicine 1999, 1: 169. PMID: 11229550.Peer-Reviewed Original ResearchTwo-year follow-up after intracoronary gamma radiation therapy
Condado J, Waksman R, Calderas C, Saucedo J, Lansky A. Two-year follow-up after intracoronary gamma radiation therapy. Cardiovascular Revascularization Medicine 1999, 1: 30-35. PMID: 11272353, DOI: 10.1016/s1522-1865(98)00014-6.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyIntracoronary gamma radiation therapyGamma radiation therapyRadiation therapyBinary restenosisAngiographic binary restenosisMean late lossLate luminal lossTransluminal coronary angioplastyEndovascular revascularization proceduresAngiographic complicationsEarly pseudoaneurysmRestenosis indexAngiographic outcomesLate complicationsCoronary angioplastyRevascularization proceduresLuminal lossLate aneurysmSpontaneous regressionUnfavorable remodelingSerial angiographyLate effectsLate lossLong-term effects