2022
Left Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial.
O'Neill WW, Wang DD, Polak S, Moses JW, Josephy N, Koenig G, Kim RJ, Lansky A, Bellumkonda L, Douglas PS, Kapur NK. Left Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial. Journal Of Invasive Cardiology 2022, 34: e611-e619. PMID: 35830361, DOI: 10.25270/jic/21.00401.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceLV ejection fractionInfarct sizeLeft ventricularLV unloadingEjection fractionPilot trialGroup 2Group 1ST-segment elevation myocardial infarction (STEMI) patientsImproved LV ejection fractionElevation myocardial infarction patientsLV end-diastolic volumeMajor cardiovascular outcomesPercutaneous coronary interventionMyocardial infarction patientsEnd-diastolic volumeEnd-systolic volumeAnterior STEMIEchocardiographic LVEFCardiogenic shockCardiovascular outcomesEchocardiographic parametersImmediate reperfusionCoronary intervention
2021
Outcomes of bailout percutaneous ventricular assist device versus prophylactic strategy in patients undergoing nonemergent percutaneous coronary intervention
O'Neill BP, Grines C, Moses JW, Ohman EM, Lansky A, Popma J, Kapur NK, Schreiber T, Mannino S, O'Neill WW, Medjamia AM, Mahmud E. Outcomes of bailout percutaneous ventricular assist device versus prophylactic strategy in patients undergoing nonemergent percutaneous coronary intervention. Catheterization And Cardiovascular Interventions 2021, 98: e501-e512. PMID: 34051033, DOI: 10.1002/ccd.29758.Peer-Reviewed Original ResearchConceptsPercutaneous ventricular assist deviceNonemergent percutaneous coronary interventionPercutaneous coronary interventionHemodynamic collapseVentricular assist deviceCoronary interventionProphylactic supportImpella percutaneous ventricular assist deviceAssist deviceOutcomes of patientsVentricular ejection fractionHospital mortalityHospital outcomesEjection fractionHeart failureMedian baselinePVAD supportProphylactic strategiesFemale genderStudy populationLow prevalencePatientsMain diseaseOutcomesMortality
2017
Predictors of Left Ventricular Ejection Fraction Improvement After Primary Stenting in ST-Segment Elevation Myocardial Infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trial)
Serrao GW, Lansky AJ, Mehran R, Stone GW. Predictors of Left Ventricular Ejection Fraction Improvement After Primary Stenting in ST-Segment Elevation Myocardial Infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trial). The American Journal Of Cardiology 2017, 121: 678-683. PMID: 29394998, DOI: 10.1016/j.amjcard.2017.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntithrombinsBiomarkersCoronary AngiographyFemaleHeparinHirudinsHumansMaleMiddle AgedPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexPredictive Value of TestsRecombinant ProteinsRisk AssessmentRisk FactorsST Elevation Myocardial InfarctionStentsStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionLeft ventricular ejection fractionPrimary PCIAcute Myocardial Infarction trialMyocardial Infarction trialElevation myocardial infarctionHarmonizing OutcomesLVEF improvementMyocardial infarctionLower baseline left ventricular ejection fractionLeft ventricular ejection fraction improvementBaseline left ventricular ejection fractionGlycoprotein IIb/IIIa inhibitorsVentricular ejection fraction improvementMyocardial Infarction 3 flowIIb/IIIa inhibitorsEjection fraction improvementHalf of patientsPercutaneous coronary interventionVentricular ejection fractionPredictors of improvementPrespecified substudyPrimary stentingAngiographic predictors
2011
The Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and No-Reflow After Stenting in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Wu X, Mintz GS, Xu K, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA, Dressler O, Parise H, Mehran R, Stone GW, Maehara A. The Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and No-Reflow After Stenting in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. JACC Cardiovascular Interventions 2011, 4: 495-502. PMID: 21596321, DOI: 10.1016/j.jcin.2010.12.012.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary CirculationEuropeHumansLogistic ModelsMulticenter Studies as TopicMyocardial InfarctionNo-Reflow PhenomenonPlaque, AtheroscleroticPredictive Value of TestsRandomized Controlled Trials as TopicRetrospective StudiesRisk AssessmentRisk FactorsStentsStroke VolumeTreatment OutcomeUltrasonography, InterventionalUnited StatesVentricular Function, LeftConceptsAcute myocardial infarctionAttenuated plaqueHORIZONS-AMI trialPercutaneous coronary interventionMyocardial infarctionAttenuation scoreIntravascular ultrasoundVentricular ejection fractionGrayscale intravascular ultrasoundAngiographic thrombusFinal ThrombolysisCoronary interventionDistal embolizationEjection fractionMechanical obstructionTransient deteriorationCoronary flowStent implantationNo-ReflowPatientsMultivariate analysisLower baselineStent expansionInfarctionPlaques
2010
Clinical and Angiographic Predictors of Short- and Long-Term Ischemic Events in Acute Coronary Syndromes
Lansky AJ, Goto K, Cristea E, Fahy M, Parise H, Feit F, Ohman EM, White HD, Alexander KP, Bertrand ME, Desmet W, Hamon M, Mehran R, Moses J, Leon M, Stone GW. Clinical and Angiographic Predictors of Short- and Long-Term Ischemic Events in Acute Coronary Syndromes. Circulation Cardiovascular Interventions 2010, 3: 308-316. PMID: 20647564, DOI: 10.1161/circinterventions.109.887604.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeLeft ventricular ejection fractionEarly invasive strategyPercutaneous coronary interventionVentricular ejection fractionComposite ischemiaIschemic eventsACS patientsAngiographic predictorsCoronary syndromeCoronary interventionEjection fractionInvasive strategyUrgent Intervention Triage Strategy (ACUITY) trialLong-term ischemic eventsCoronary artery bypassCardiac ischemic eventsClinical risk factorsPrognosis of patientsInsulin-treated diabetesMultivariable logistic regressionIndependent predictive valueLower hemoglobin valuesPercent diameter stenosisST-segment deviation
2006
Comparative Early and Late Outcomes After Primary Percutaneous Coronary Intervention in ST-Segment Elevation and Non–ST-Segment Elevation Acute Myocardial Infarction (from the CADILLAC Trial)
Cox DA, Stone GW, Grines CL, Stuckey T, Zimetbaum PJ, Tcheng JE, Turco M, Garcia E, Guagliumi G, Iwaoka RS, Mehran R, O’Neill W, Lansky AJ, Griffin JJ, Investigators C. Comparative Early and Late Outcomes After Primary Percutaneous Coronary Intervention in ST-Segment Elevation and Non–ST-Segment Elevation Acute Myocardial Infarction (from the CADILLAC Trial). The American Journal Of Cardiology 2006, 98: 331-337. PMID: 16860018, DOI: 10.1016/j.amjcard.2006.01.102.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAnticoagulantsBlood Vessel Prosthesis ImplantationCoated Materials, BiocompatibleElectrocardiographyFemaleFollow-Up StudiesHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionPlatelet Glycoprotein GPIIb-IIIa ComplexStentsStroke VolumeSurvival RateTime FactorsTreatment OutcomeConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPrimary PCIMyocardial Infarction (TIMI) grade 3 flowIschemic target vessel revascularizationGrade 3 flowOutcomes of patientsTarget vessel revascularizationPercutaneous coronary interventionVessel revascularizationAcute MICoronary interventionMyocardial infarctionAcute ST-segment elevation myocardial infarctionSegment elevation acute myocardial infarctionMajor adverse cardiac eventsElevation acute myocardial infarctionOngoing chest painSimilar late mortalityAdverse cardiac eventsElevation myocardial infarctionST-segment elevationAcute myocardial infarctionHigher ejection fractionPostprocedural Thrombolysis
2004
Impact of intravenous Beta-Blockade before primary angioplasty on survival in patients undergoing mechanical reperfusion therapy for acute myocardial infarction
Halkin A, Grines CL, Cox DA, Garcia E, Mehran R, Tcheng JE, Griffin JJ, Guagliumi G, Brodie B, Turco M, Rutherford BD, Aymong E, Lansky AJ, Stone GW. Impact of intravenous Beta-Blockade before primary angioplasty on survival in patients undergoing mechanical reperfusion therapy for acute myocardial infarction. Journal Of The American College Of Cardiology 2004, 43: 1780-1787. PMID: 15145099, DOI: 10.1016/j.jacc.2003.10.068.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIBeta-blocker useMyocardial recoveryMyocardial infarctionLate Angioplasty Complications (CADILLAC) trialOral beta-blocker medicationOral beta-blocker useLeft ventricular ejection fractionIntravenous beta blockadeMechanical reperfusion therapyAbsence of contraindicationsBeta-blocker therapyBeta-blocker medicationBeta-blocker administrationPercutaneous coronary interventionVentricular ejection fractionBeta blockadeControlled AbciximabPrimary angioplastyReperfusion therapyComplications TrialCoronary interventionSurvival benefit
2002
Comparison of clinical outcomes using stents versus no stents after percutaneous coronary intervention for proximal left anterior descending versus proximal right and left circumflex coronary arteries
Ashby DT, Dangas G, Mehran R, Lansky AJ, Narasimaiah R, Iakovou I, Polena S, Satler LF, Pichard AD, Kent KM, Stone GW, Leon MB. Comparison of clinical outcomes using stents versus no stents after percutaneous coronary intervention for proximal left anterior descending versus proximal right and left circumflex coronary arteries. The American Journal Of Cardiology 2002, 89: 1162-1166. PMID: 12008168, DOI: 10.1016/s0002-9149(02)02297-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriesBlood Vessel Prosthesis ImplantationCohort StudiesCoronary Artery DiseaseCoronary RestenosisCoronary VesselsDistrict of ColumbiaFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative ComplicationsRadiographyStentsStroke VolumeSurvival AnalysisTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionTarget lesion revascularizationProximal LAD arteryProximal rightClinical restenosisCoronary interventionCircumflex arteryProcedural successLAD arteryProximal coronary artery stenosisSingle-vessel coronary diseaseAnterior descending (LAD) stenosisHigh rateCircumflex coronary arteryLower procedural successCoronary artery stenosisSignificant differencesDifferent lesion locationsCoronary artery stentsLesion revascularizationProximal LADCoronary diseaseArtery stenosisClinical outcomesHospital events