2024
Long-Term Outcomes of Transcatheter vs Surgical Aortic Valve Replacement: Meta-analysis of Randomized Trials
Talanas G, Laconi A, Kereiakes D, Merella P, Reardon M, Spano A, Petretto G, Lauriola F, Casula M, Micheluzzi V, Isgender M, Chatzizisis Y, Farkouh M, Lansky A, Piazza N, Portoghese M, Casu G, Navarese E. Long-Term Outcomes of Transcatheter vs Surgical Aortic Valve Replacement: Meta-analysis of Randomized Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102143. PMID: 39131994, PMCID: PMC11307397, DOI: 10.1016/j.jscai.2024.102143.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementLong-term outcomesMeta-analysis of randomized trialsSevere aortic stenosisValve replacementValve thrombosisPacemaker implantationValve gradientAortic stenosisParavalvular leakFollow-upStroke riskRandomized trialsLong-term outcomes of patientsBalloon-expandable transcatheter aortic valve replacementSelf-expanding transcatheter aortic valve replacementSafety of transcatheter aortic valve replacementRisk of transcatheter aortic valve replacementRisk of pacemaker implantationSecondary end pointsSurgical risk profileOutcomes of patientsMeta-analysis
2022
Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Van Mieghem N, Deeb G, Søndergaard L, Grube E, Windecker S, Gada H, Mumtaz M, Olsen P, Heiser J, Merhi W, Kleiman N, Chetcuti S, Gleason T, Lee J, Cheng W, Makkar R, Crestanello J, George B, George I, Kodali S, Yakubov S, Serruys P, Lange R, Piazza N, Williams M, Oh J, Adams D, Li S, Reardon M, Gitter C, Meyer K, Roberts D, Bae R, Sorajja P, Sun B, Askew J, Eales F, Flavin T, Goessl M, Kshettry V, Mooney M, Pedersen W, Poulose A, Roohani P, Saeid Farivar R, Shronts R, Tarrel R, Young M, Butkus E, Pendleton K, Fry R, Heine C, La Roe K, Tran T, Weig L, Agarwal H, Langdon T, Satpathy R, Batter J, Bremer K, Indukuri U, Baas M, Oomes-Sistermans C, Smits M, Coenen C, Driesen I, Lauryssen L, Poorter M, Schaap J, Bentala M, den Heijer P, Pieter J, Remmers M, Story M, van Erven P, Verbiest H, Vos J, Bennett M, Dunaj W, Seaton D, Waller D, Khandheria B, Bajwa T, O'Hair D, Ahmed A, Allaqaband S, Gheith A, Marriott E, Qhavi A, Saxena V, Shhadeh A, Werner P, Yeomans C, Bessette L, Byrne J, Kieckhefer H, Munoz M, Russo E, Klein J, Morgan M, Byrne T, Caskey M, Amabile O, Brady K, Chung S, Dacanay K, Fang H, Franz D, Kelly C, Loli A, Payne J, Pershad A, Wang N, Lott J, Pool-Owens C, Porter C, Hennan J, Garrett H, Paulus B, Craig J, Elijovich L, Samaha J, Wolf B, Wright L, Zoghbi G, Willcott L, Roberts B, Hebeler R, Stoler R, Graybeal D, Grayburn P, Henry C, Mir O, Vallabhan R, Fanous M, Kaufman J, Chang J, Manning W, Riley M, Khabbaz K, Laham R, Popma J, Burke D, Caplan L, Chui S, Guibone K, Kumar S, Lioutas V, Liu D, Nathan S, Pinto D, Searls D, Fisher S, Guirgues L, Henderson S, Loving L, McWalters N, Patterson K, Burkart J, Carcedo B, Stacey R, Bladergroen M, Lim D, Edmonson S, Epps S, Katz M, Ng K, Sangha A, Aucoin J, Roberts M, Aubin J, Hotard C, Tassin M, Fail P, Feinberg E, Netherland D, Abben R, Allam M, Bates M, Dearman R, Gervais D, Haight E, Metes M, Naquin J, Tedesco V, Thibodeaux L, Thompson K, Aberle S, Amaro D, Grey W, Rose G, Scherer M, Rinaldi M, Skipper E, Bridges C, Downey W, Iyengar P, Martin J, Ryan L, Stiegel R, Story J, Alsabaawi K, Gheorghiu M, Singh C, Yashar J, Siegel R, Cheng W, Makkar R, Altman K, Jilaihawi H, Kar S, Khouw S, Mody C, Ramzy D, Salseth T, Stegic J, Trento A, Lazarte R, Sohn J, Hahn R, Khalique O, George I, Kodali S, Williams M, Gonzalez Castellon M, Gutierrez Contreras J, Kitago T, Kummer B, Lekic T, Miller E, Naka Y, Nazif T, Qureshi A, Rostanski S, Smith C, Willey J, Yaghi S, Abreu L, Clement E, Sabir S, Aji J, Bowen F, Kaddissi G, Mirsen T, Muntazar M, Ogbara J, Rosenbloom M, Schell W, Then R, Carl H, Huang H, Kreydi G, Wolak H, Sandidge G, Ali O, Asfaw Z, Henry S, Kafi A, Schreiber T, Andaya L, Baciewicz F, Bassett J, Choksi N, Kassas S, Munir A, Kothmeier F, Stroh A, Goppel G, Hettich I, Bleiziffer S, Hengstenberg C, Opitz A, Ruge H, Badiu C, Brenner S, Ehlmidi Y, Herold U, Kasel A, Kreuzpointner R, Lange R, Mazzitelli D, Poppert H, Seifert C, Vincze D, Voss B, Camuglia K, Cowhig D, Newbold S, Pierce C, 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E, Ischida K, Loulmet D, Siller K, Staniloae C, Torres J, Zhang C, Hartlev C, Huffman A, Jones D, Kellum A, Liptrot R, Orsinelli D, Ryan J, Ryan T, Crestanello J, George B, Lilly S, Rushing G, Grose N, Kilic A, Lee V, Mazzaferri E, Mutgi S, O'Neil S, Perchuk A, Sai-Sudhakar C, Slivka A, Cheatham J, Hanes S, Banowetz M, Dautenhahn D, Mehl B, Bodenhamer R, Ghani M, Raikar G, Randolph J, Tahirkheli N, Wasemiller W, Williams J, Amoroso E, Holt S, Tucker C, Martin R, Kauten J, Rajagopal V, Awad E, Brown W, Dean D, Gott J, Karmpaliotis D, Meduri C, Polsani V, Rinehart S, Russell C, Seiden L, Serbanescu A, Vannan M, Butler K, Elsessor K, Fehr B, Hancock A, Hollister R, MacFarlane D, Rodgers C, Todd A, Eubanks V, Spangler J, Wirt K, Wonders B, Bachinsky W, Gada H, Maini B, Mumtaz M, Aneja P, Loran D, Shah J, Gebhardt L, Jones U, Lauterborn M, John H, Parthier S, Schaprian K, Twelker K, Nickenig G, Welz A, Bode F, Fuchs A, Grube E, Mellert F, Petzold G, Sedaghat A, Sinning J, Vasa-Nicotera M, 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Brown D, Ryan W, Brinkman W, Gopal A, Harrington K, Mack M, Nosnik P, Potluri S, Smith R, Szerlip M, Blaylock C, Brinegar P, Canter L, Green L, Green L, Hazen P, Jacobs A, Khan S, Ludwig S, Mata M, Moore T, Underwood C, Faza N, Little S, Nagueh S, Kleiman N, Reardon M, Albright K, Atkins M, Barker C, Bledsoe D, Chiu D, Goel S, Gray T, Imperial-Aubin D, Lin C, Moye S, Ramchandani M, Ramlawi B, Reul R, Reyes M, Scheinin S, Volpi J, White S, Wyler von Ballmoos M, Blackburn B, Wong R, Hart C, Whitacker P, Lau J, Spies C, Badawi R, Graner S, Nakamura D, Plank B, Salem R, Seto T, Valenta D, Cruz A, Gallagher L, Schuck L, Siki M, Weeks A, Fishman L, Schwarz T, Bavaria J, Herrmann H, Anwaruddin S, Desai N, Giri J, Khella S, Li R, McGarvery M, Messe S, Price R, Quinn C, Szeto W, Vallabhajosyula P, Sun Y, Wu L, Tsang W, Thavendiranathan D, Feindel C, Horlick E, Casaubon L, Cusimano R, Del Campo M, Osten M, Silver F, Höwisch-Pengel R, Lechner G, Steiger B, Allgeier M, Jander N, Beyersdorf F, Neumann F, Büttner H, Comberg T, Diab N, Gick M, Günkel L, Pingpoh C, Rothe H, Siepe M, Thoma M, Winker T, Hager C, Sänger U, Stader M, Biaggi P, Gruner C, Stämpfli S, Binder R, Corti R, Falk V, Holy E, Maisano F, Grünenfelder J, Holubec T, Maier W, Nietlispach F, Wegener S, Atkinson R, Davis A, Hall S, Mangene S, Mazzurco S, Hoit B, Musarra R, Costa M, Markowitz A, Asi K, Attizzani G, Chuang D, Elgudin Y, Garcia C, Jadhav V, Le S, Miller B, Serkin Z, Shams T, Sila C, Simon D, Bezerra H, Deo S, Anderson J, Greening K, Karson J, Page S, Shawgo T, Freeman J, Mulhern K, Nath J, Tadros P, Zorn G, Hockstad E, Lechtenberg C, Muehlebach G, Rippee M, Rosterman L, Sundararajan J, Wang Y, Wiley M, Atapattu S, Marin y Kall C, Lowery M, de Marchena E, Salerno T, Alfonso C, Carillo R, Ferreira A, Panos A, Romano J, Williams D, Bhatt S, Migda E, Oakley J, Warshal W, Wilcock S, Booher A, LaBounty T, Chetcuti S, Deeb G, Adelman E, Boyle M, Geml R, Grossman P, Guerin D, Hodges K, Kim K, Lammers D, McDermott M, Menees D, Pace R, Patel H, Prager R, Ramchandren S, Romano M, Stamper A, Wang M, Zahuranec D, Ziarkiewicz M, Charlebois C, Chilton C, Labinaz M, Ruel M, Glover C, Lam K, Masters R, Steffenhagen N, Enlow-Germovsek M, Konopka K, McGargle R, Travis M, Anderson K, Cavalcante J, Crock F, Edelman K, Katz W, Gleason T, Lee J, Sultan I, Aghaebrahim A, Al-Bayai A, Bonaccorsi C, Campbell D, Giurgiutiu D, Gulati D, Hawkes C, Henry L, Jadhav A, Kenmuir C, Klein B, Kliner D, Limaye K, Nanduri S, Navid F, Patel P, Rangaraju S, Rocha M, Schindler J, Shoirah H, Streib C, Tadi P, Tememe D, Totoraitis R, Walker G, Ziayee H, Caufield L, Yeager C, Forbes J, Schwart K, Knight P, Ling F, Benesch C, Bogachan S, Hicks G, Kelly A, Narins C, Stuver T, Adams K, Blair-Anton L, Haynes M, Watts C, Baker M, Mendes L, Ball S, Goel K, Kaiser C, Robbins M, Zhao D, Ahmad R, Crenshaw M, Fredi J, Hermann L, Hoff S, Kirshner H, Levack M, Mittal S, O'Duffy A, Petracek M, Baer J, Liang G, Nguyen S, Heidenreich P, Nguyen P, Burdon T, Giacomini J, Yong C, Buchbinder M, Fann J, Kilgore S, Mitchell R, McDaniel S, Pack A, White W, Young T, Burgess P, Pu M, Upadhya B, Applegate R, Kon N, Arnan M, Baghshomali S, Bishop L, Bradbury E, Gandhi S, Kincaid E, Lefkowitz D, Lisle B, Batteria M, Rerisi E, Stepinowski K, Senicola T, Goncalves J, Schubach S, Schwartz R, Antaky K, Christiansen C, Marzo K, Michel K, Misra A, Varghese P, Wirkowski E, Levesque L, Sugeng L, Cleman M, Forrest J, Hashim S, Mangi A, Amin H, Darr U, Dewar M, Faheem O, Geirsson A, Greer D, Kaleel A, Kaple R, Lansky A, MacGrory B, Pfau S, Schindler J, Thompson C, Youn T, Yuh D, Yun J. Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients. JAMA Cardiology 2022, 7: 1000-1008. PMID: 36001335, PMCID: PMC9403849, DOI: 10.1001/jamacardio.2022.2695.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSevere aortic valve stenosisIntermediate-risk patientsAortic valve stenosisValve replacementAdverse eventsAortic stenosisValve stenosisParavalvular leakClinical trialsIndependent echocardiographic core laboratorySurgical aortic valve replacementSymptomatic severe aortic stenosisIndependent clinical events committeePrespecified secondary end pointsEchocardiographic core laboratoryIntermediate surgical riskIntermediate-risk subjectsLocal heart teamSecondary end pointsSerious adverse eventsSevere aortic stenosisSymptomatic aortic stenosisAortic valve areaOutcomes of the Novel Supreme Drug-Eluting Stent in Complex Coronary Lesions: A PIONEER III Substudy
Patel K, Lansky A, Kereiakes D, Windecker S, Cristea E, Pietras C, Dressler O, Issever M, Curtis M, Bertolet B, Zidar J, Smits P, Díaz V, McLaurin B, Brogno D, Janssens L, Vrolix M, Gómez-Blázquez I, Sahul Z, Kabour A, Salido L, Cleman M, Saito S, Leon M, Baumbach A, Investigators I. Outcomes of the Novel Supreme Drug-Eluting Stent in Complex Coronary Lesions: A PIONEER III Substudy. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100004. PMID: 39130138, PMCID: PMC11308031, DOI: 10.1016/j.jscai.2021.100004.Peer-Reviewed Original ResearchDrug-eluting stentsTarget lesion failureDP-EESComplex lesionsLesion failureAdverse eventsLesion complexityMajor adverse cardiac eventsSingle-blind clinical trialEnd pointAdverse cardiac eventsChronic coronary syndromePrimary end pointSecondary end pointsTarget lesion revascularizationTarget vessel failureComplex coronary lesionsPercutaneous coronary interventionEverolimus-eluting stentsDrug eluting stentsHigh rateLesion revascularizationCoronary syndromeCardiac eventsCoronary intervention
2011
5-Year Follow-Up of Polytetrafluoroethylene-Covered Stents Compared With Bare-Metal Stents in Aortocoronary Saphenous Vein Grafts The Randomized BARRICADE (Barrier Approach to Restenosis: Restrict Intima to Curtail Adverse Events) Trial
Stone GW, Goldberg S, O'Shaughnessy C, Midei M, Siegel RM, Cristea E, Dangas G, Lansky AJ, Mehran R. 5-Year Follow-Up of Polytetrafluoroethylene-Covered Stents Compared With Bare-Metal Stents in Aortocoronary Saphenous Vein Grafts The Randomized BARRICADE (Barrier Approach to Restenosis: Restrict Intima to Curtail Adverse Events) Trial. JACC Cardiovascular Interventions 2011, 4: 300-309. PMID: 21435608, DOI: 10.1016/j.jcin.2010.11.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoated Materials, BiocompatibleCoronary AngiographyCoronary Artery BypassCoronary RestenosisFemaleGraft Occlusion, VascularHumansKaplan-Meier EstimateMaleMetalsMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPolytetrafluoroethyleneProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsSaphenous VeinStentsThrombosisTime FactorsTreatment OutcomeUnited StatesConceptsSaphenous vein graftsBare metal stentsPercutaneous coronary interventionDiseased saphenous vein graftsHigh-pressure implantationDual antiplatelet therapyTarget vessel failureAntiplatelet therapyMajor secondary end pointEnd pointPrimary end pointSecondary end pointsLong-term prognosisBinary restenosisBMS patientsCoronary interventionVein graftsVessel failureInferior outcomesSaphenous veinDiscrete lesionsPatientsPrior trialsJostentLesionsRationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction
Gibson CM, Maehara A, Lansky AJ, Wohrle J, Stuckey T, Dave R, Cox D, Grines C, Dudek D, Steg G, Parise H, Wolff SD, Cristea E, Stone GW. Rationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction. American Heart Journal 2011, 161: 478-486.e7. PMID: 21392601, DOI: 10.1016/j.ahj.2010.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAntithrombinsCoronary OcclusionCoronary ThrombosisEndpoint DeterminationHirudinsHumansImmunoglobulin Fab FragmentsInfusions, Intra-ArterialMagnetic Resonance Imaging, CineMyocardial InfarctionPatient SelectionPeptide FragmentsPlatelet Aggregation InhibitorsRecombinant ProteinsResearch DesignThrombectomyConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionPrimary PCIAnterior ST-elevation myocardial infarctionExport aspiration catheterPercutaneous coronary interventionLocal infusionThrombus aspirationInfarct sizeINFUSE-AMIEnd pointCoronary interventionAspiration catheterMyocardial infarctionInfusion catheterAnterior ST-segment elevation myocardial infarctionST-segment elevation myocardial infarctionSingle-blind randomized studyCardiac magnetic resonance imagingMyocardial infarction 0Mid-left anteriorPrimary end pointSafety end pointSecondary end pointsST-segment resolution
2010
Everolimus-Eluting versus Paclitaxel-Eluting Stents in Coronary Artery Disease
Stone GW, Rizvi A, Newman W, Mastali K, Wang JC, Caputo R, Doostzadeh J, Cao S, Simonton CA, Sudhir K, Lansky AJ, Cutlip DE, Kereiakes DJ. Everolimus-Eluting versus Paclitaxel-Eluting Stents in Coronary Artery Disease. New England Journal Of Medicine 2010, 362: 1663-1674. PMID: 20445180, DOI: 10.1056/nejmoa0910496.Peer-Reviewed Original ResearchConceptsPaclitaxel-eluting stentsTarget lesion failureEverolimus-eluting stentsMajor secondary end pointPrimary end pointSecondary end pointsEnd pointMyocardial infarctionIschemia-driven target lesion revascularizationRoutine follow-up angiographyTarget vessel myocardial infarctionComposite rateTarget lesion revascularizationClinical end pointsCoronary artery diseaseSubgroup of patientsFollow-up angiographyEverolimus-ElutingAngiographic findingsPrespecified subgroupsArtery diseaseCardiac deathStent thrombosisPatientsStents
2009
Paclitaxel-Eluting Stents versus Bare-Metal Stents in Acute Myocardial Infarction
Stone GW, Lansky AJ, Pocock SJ, Gersh BJ, Dangas G, Wong SC, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Möckel M, Ochala A, Kellock A, Parise H, Mehran R. Paclitaxel-Eluting Stents versus Bare-Metal Stents in Acute Myocardial Infarction. New England Journal Of Medicine 2009, 360: 1946-1959. PMID: 19420364, DOI: 10.1056/nejmoa0810116.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryCombined Modality TherapyCoronary AngiographyCoronary RestenosisCoronary StenosisDrug-Eluting StentsFemaleFibrinolytic AgentsFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPaclitaxelRecurrenceRetreatmentRiskStentsSwedenConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPaclitaxel-eluting stentsBare metal stentsElevation myocardial infarctionTarget lesion revascularizationMyocardial infarctionAngiographic evidenceEnd pointStent thrombosisIschemia-driven target lesion revascularizationPrimary PCIComposite safety end pointIdentical bare-metal stentMajor secondary end pointPrimary end pointSafety end pointSecondary end pointsTarget vessel revascularizationPercutaneous coronary interventionRepeat revascularization proceduresAcute myocardial infarctionSafety outcome measuresDrug-eluting stentsBinary restenosisThe GENESIS (Randomized, Multicenter Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries) Trial
Verheye S, Agostoni P, Dawkins KD, Dens J, Rutsch W, Carrie D, Schofer J, Lotan C, Dubois CL, Cohen SA, Fitzgerald PJ, Lansky AJ. The GENESIS (Randomized, Multicenter Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries) Trial. JACC Cardiovascular Interventions 2009, 2: 205-214. PMID: 19463427, DOI: 10.1016/j.jcin.2008.12.011.Peer-Reviewed Original ResearchConceptsPaclitaxel-eluting stentsMajor adverse cardiac event ratesAdverse cardiac event ratesSingle de novo lesionsMajor adverse clinical eventsStent late lumen lossEnd pointBinary angiographic restenosisCardiac event ratePrimary end pointSecondary end pointsDe novo lesionsRandomized multicenter trialAdverse clinical eventsStent late lossLate lumen lossNative coronary arteriesStent restenosis rateBare metal stentsAngiographic restenosisNovo lesionsCoronary angiographyMulticenter trialRestenosis rateLumen loss9-Month Clinical, Angiographic, and Intravascular Ultrasound Results of a Prospective Evaluation of the Axxess Self-Expanding Biolimus A9-Eluting Stent in Coronary Bifurcation Lesions The DIVERGE (Drug-Eluting Stent Intervention for Treating Side Branches Effectively) Study
Verheye S, Agostoni P, Dubois CL, Dens J, Ormiston J, Worthley S, Trauthen B, Hasegawa T, Koo BK, Fitzgerald PJ, Mehran R, Lansky AJ. 9-Month Clinical, Angiographic, and Intravascular Ultrasound Results of a Prospective Evaluation of the Axxess Self-Expanding Biolimus A9-Eluting Stent in Coronary Bifurcation Lesions The DIVERGE (Drug-Eluting Stent Intervention for Treating Side Branches Effectively) Study. Journal Of The American College Of Cardiology 2009, 53: 1031-1039. PMID: 19298915, DOI: 10.1016/j.jacc.2008.12.012.Peer-Reviewed Original ResearchConceptsPercent neointimal volume obstructionMajor adverse cardiac eventsNeointimal volume obstructionCoronary bifurcation lesionsBifurcation lesionsAXXESS stentVolume obstructionMulticenter studyMyocardial infarctionLate lossParent vesselDe novo bifurcation lesionsEnd pointIntravascular ultrasound resultsNovo bifurcation lesionsAdverse cardiac eventsComposite of deathPrimary end pointSecondary end pointsProspective multicenter studySirolimus-eluting stentsAdverse late outcomesSide branchesDrug-eluting stentsLate stent thrombosis
2008
Comparison of an Everolimus-Eluting Stent and a Paclitaxel-Eluting Stent in Patients With Coronary Artery Disease: A Randomized Trial
Stone GW, Midei M, Newman W, Sanz M, Hermiller JB, Williams J, Farhat N, Mahaffey KW, Cutlip DE, Fitzgerald PJ, Sood P, Su X, Lansky AJ, Investigators F. Comparison of an Everolimus-Eluting Stent and a Paclitaxel-Eluting Stent in Patients With Coronary Artery Disease: A Randomized Trial. JAMA 2008, 299: 1903-1913. PMID: 18430909, DOI: 10.1001/jama.299.16.1903.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisDrug-Eluting StentsEverolimusFemaleHumansImmunosuppressive AgentsLogistic ModelsMaleMiddle AgedMyocardial InfarctionPaclitaxelProspective StudiesSingle-Blind MethodSirolimusUltrasonography, InterventionalConceptsMajor adverse cardiac eventsAdverse cardiac eventsPaclitaxel-eluting stentsSegment late lossSecondary end pointsTarget vessel failureCoronary artery diseaseCardiac eventsLate lossEnd pointArtery diseaseComposite major adverse cardiac eventsAdditional secondary end pointsMajor secondary end pointLesion revascularization proceduresSPIRIT III trialPrimary end pointReference vessel diameterPercutaneous coronary interventionEverolimus-Eluting StentsAngiographic late lossCobalt-chromium stentAgents everolimusNoninferior ratesAngiographic outcomesTreatment of diffuse IN-stent restenosis with Drug-Eluting stents vs. intracoronary bEta-raDiation therapy: INDEED Study
Park SW, Lee SW, Bon Kwon Koo, Park DW, Lee SW, Kim YH, Lee CW, Hong MK, Kim JJ, Mori K, Lansky AJ, Mintz GS, Lee MM, Park SJ. Treatment of diffuse IN-stent restenosis with Drug-Eluting stents vs. intracoronary bEta-raDiation therapy: INDEED Study. International Journal Of Cardiology 2008, 131: 70-77. PMID: 18190986, DOI: 10.1016/j.ijcard.2007.09.003.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsIntracoronary brachytherapySES implantationMyocardial infarctionGroup IILate lossGroup IDiffuse ISRAngiographic restenosisSirolimus-eluting stent implantationEnd pointMore effective treatment modalitiesBare-metal ISRAdverse cardiac eventsPrimary end pointSecondary end pointsEffective treatment modalityIn-Stent RestenosisDrug-eluting stentsLesion revascularizationBaseline characteristicsCardiac eventsCardiac deathLower restenosisStent implantation
2005
Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial
Stone GW, Webb J, Cox DA, Brodie BR, Qureshi M, Kalynych A, Turco M, Schultheiss HP, Dulas D, Rutherford BD, Antoniucci D, Krucoff MW, Gibbons RJ, Jones D, Lansky AJ, Mehran R, Investigators F. Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial. JAMA 2005, 293: 1063-1072. PMID: 15741528, DOI: 10.1001/jama.293.9.1063.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionST-segment resolutionAcute ST-segment elevation myocardial infarctionMajor adverse cardiac eventsAdverse cardiac eventsEvent-free survivalElevation myocardial infarctionDistal protectionInfarct sizeMyocardial infarctionCardiac eventsCoronary interventionReperfusion successBalloon occlusionEmergent percutaneous coronary interventionComplete ST-segment resolutionPrimary percutaneous coronary interventionEnd pointDistal balloon occlusionDistal embolic protectionPrimary PCI resultsCoprimary end pointsSecondary end pointsAcute myocardial infarction
2004
Non–Polymer-Based Paclitaxel-Coated Coronary Stents for the Treatment of Patients With De Novo Coronary Lesions
Lansky AJ, Costa RA, Mintz GS, Tsuchiya Y, Midei M, Cox DA, O’Shaughnessy C, Applegate RA, Cannon LA, Mooney M, Farah A, Tannenbaum MA, Yakubov S, Kereiakes DJ, Wong SC, Kaplan B, Cristea E, Stone GW, Leon MB, Knopf WD, O’Neill W. Non–Polymer-Based Paclitaxel-Coated Coronary Stents for the Treatment of Patients With De Novo Coronary Lesions. Circulation 2004, 109: 1948-1954. PMID: 15078794, DOI: 10.1161/01.cir.0000127129.94129.6f.Peer-Reviewed Original ResearchConceptsTarget vessel failureDe novo coronary lesionsNovo coronary lesionsBinary restenosisEnd pointCoronary lesionsMore type C lesionsPrespecified primary end pointPrespecified end pointStent binary restenosisBaseline clinical characteristicsPrimary end pointSecondary end pointsType C lesionsSmooth muscle cell proliferationMulticenter Clinical EvaluationStent late lossTreatment of patientsLarger reference diameterMuscle cell proliferationMicrotubule-stabilizing compoundClinical characteristicsPotent antitumor activityC lesionsClinical evaluationRandomized trial of Rotational Atherectomy Versus Balloon Angioplasty for Diffuse In-stent Restenosis (ROSTER)
Sharma SK, Kini A, Mehran R, Lansky A, Kobayashi Y, Marmur JD. Randomized trial of Rotational Atherectomy Versus Balloon Angioplasty for Diffuse In-stent Restenosis (ROSTER). American Heart Journal 2004, 147: 16-22. PMID: 14691413, DOI: 10.1016/j.ahj.2003.07.002.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationPrimary end pointDiffuse ISRPTCA groupBalloon angioplastyBalloon dilatationStent restenosisCoronary artery bypass graft proceduresIn-Stent Restenosis TrialStudy's primary end pointEnd pointHigh-pressure balloon dilatationRotational coronary atherectomySecondary end pointsBypass graft proceduresIntravascular ultrasound studyAcute luminal gainAdjunctive balloon dilatationIntimal hyperplasia areaAngiographic substudyAngiographic variablesLesion revascularizationRepeat stentingAngiographic restenosisAngiographic success
2000
The PARAGON stent study: a randomized trial of a new martensitic nitinol stent versus the Palmaz-Schatz stent for treatment of complex native coronary arterial lesions
Holmes D, Lansky A, Kuntz R, Bell M, Buchbinder M, Fortuna R, O’Shaughnessy C, Popma J, Investigators F. The PARAGON stent study: a randomized trial of a new martensitic nitinol stent versus the Palmaz-Schatz stent for treatment of complex native coronary arterial lesions. The American Journal Of Cardiology 2000, 86: 1073-1079. PMID: 11074202, DOI: 10.1016/s0002-9149(00)01162-0.Peer-Reviewed Original ResearchConceptsStent minimal lumen diameterTarget vessel failureMinimal lumen diameterAngiographic restenosisPalmaz-SchatzLumen diameterPS stentEnd pointSignificant differencesAverage stent lengthBinary angiographic restenosisInfrequent adverse eventsPrimary end pointSecondary end pointsSmaller reference vesselsCoronary arterial lesionsNative coronary lesionsPrior bypass surgeryLong-term outcomesPalmaz-Schatz stentsPrior restenosisLesion revascularizationPercutaneous revascularizationBypass surgeryClinical restenosis