2019
Safety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses
Ali ZA, Nef H, Escaned J, Werner N, Banning AP, Hill JM, De Bruyne B, Montorfano M, Lefevre T, Stone GW, Crowley A, Matsumura M, Maehara A, Lansky AJ, Fajadet J, Di Mario C. Safety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses. Circulation Cardiovascular Interventions 2019, 12: e008434. PMID: 31553205, DOI: 10.1161/circinterventions.119.008434.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCoronary AngiographyCoronary StenosisEuropeFemaleHumansLithotripsyMaleMiddle AgedPatient SafetyPercutaneous Coronary InterventionProspective StudiesRisk FactorsSeverity of Illness IndexStentsTime FactorsTomography, Optical CoherenceTreatment OutcomeUnited StatesVascular CalcificationConceptsSevere coronary artery calcificationCoronary artery calcificationMajor adverse cardiac eventsAdverse cardiac eventsPrimary end pointIntravascular lithotripsyOptical coherence tomographyCardiac eventsStent implantationPlaque fractureHospital major adverse cardiac eventsNon-Q-wave myocardial infarctionOptical coherence tomography substudyIndependent clinical events committeeCoherence tomographyDrug-eluting stent implantationEnd pointCoronary intravascular lithotripsyClinical events committeeHigh procedural successIndependent core laboratoryAcute luminal gainPost-approval studiesMechanism of actionCalcium fracture
2015
Prognostic impact of multivessel versus culprit vessel only percutaneous intervention for patients with multivessel coronary artery disease presenting with acute coronary syndrome.
Hassanin A, Brener SJ, Lansky AJ, Xu K, Stone GW. Prognostic impact of multivessel versus culprit vessel only percutaneous intervention for patients with multivessel coronary artery disease presenting with acute coronary syndrome. EuroIntervention 2015, 11: 293-300. PMID: 25136882, DOI: 10.4244/eijy14m08_05.Peer-Reviewed Original ResearchConceptsMV-percutaneous coronary interventionMajor adverse cardiac eventsPercutaneous coronary interventionAcute coronary syndromeIschaemia-driven revascularisationMyocardial infarctionNSTE-ACSCoronary syndromeMV diseaseOne-year major adverse cardiac eventsPeriprocedural non-Q-wave myocardial infarctionSegment elevation acute coronary syndromesNon-Q-wave myocardial infarctionDeath/myocardial infarctionElevation acute coronary syndromeMultivessel coronary artery diseaseUrgent Intervention Triage StrategyMultivessel percutaneous coronary interventionMV-PCI groupAdverse cardiac eventsAcute renal failureCoronary artery diseaseOne-year ratesClear clinical benefitPropensity score adjustment
2013
Efficacy and safety of FIREHAWK® abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial long cohort.
Xu B, Gao RL, Zhang RY, Wang HC, Li ZQ, Yang YJ, Ma CS, Han YL, Lansky AJ, Huo Y, Li W, Leon MB. Efficacy and safety of FIREHAWK® abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial long cohort. Chinese Medical Journal 2013, 126: 1026-32. PMID: 23506573, DOI: 10.3760/cma.j.issn.0366-6999.20123206.Peer-Reviewed Original ResearchConceptsLong coronary lesionsPercutaneous coronary interventionCoronary lesionsMyocardial infarctionLate lossLONG cohortLong lesionsBiodegradable polymer sirolimus-eluting stentsNon-Q-wave myocardial infarctionDrug-eluting stent (DES) failureLong coronary artery diseaseStent late lumen lossOne-year clinical resultsSegment binary restenosisSegment late lossPrimary end pointReference vessel diameterLate lumen lossNative coronary arteriesStent late lossCoronary artery diseaseMajor inclusion criteriaSingle-arm trialSirolimus-eluting stentsAbluminal groove
2004
Relation of final lumen dimensions in saphenous vein grafts after stent implantation to outcome
Iakovou I, Dangas G, Mintz GS, Mehran R, Kobayashi Y, Aymong E, Hirose M, Ashby DT, Lansky AJ, Stone GW, Leon MB, Moses JW. Relation of final lumen dimensions in saphenous vein grafts after stent implantation to outcome. The American Journal Of Cardiology 2004, 93: 963-968. PMID: 15081436, DOI: 10.1016/j.amjcard.2003.12.049.Peer-Reviewed Original ResearchConceptsSaphenous vein graftsAggressive stent expansionSVG lesionsStent expansionVein graftsMyocardial infarctionStent implantationHospital non-Q-wave myocardial infarctionLumen dimensionsGroup IINon-Q-wave myocardial infarctionIntravascular ultrasound-guided stentingTarget vessel revascularization rateVessel revascularization rateBaseline patient characteristicsMyocardial infarction rateNative coronary lesionsStent cross-sectional areaTarget vessel revascularizationPercutaneous coronary interventionNative coronary arteriesCross-sectional areaLower restenosis rateRevascularization ratesVessel revascularization
2003
Safety of an Aspirin-Alone Regimen After Intracoronary Stenting With a Heparin-Coated Stent
Mehran R, Aymong ED, Ashby DT, Fischell T, Whitworth H, Siegel R, Thomas W, Wong SC, Narasimaiah R, Lansky AJ, Leon MB. Safety of an Aspirin-Alone Regimen After Intracoronary Stenting With a Heparin-Coated Stent. Circulation 2003, 108: 1078-1083. PMID: 12925457, DOI: 10.1161/01.cir.0000086347.31341.f9.Peer-Reviewed Original ResearchConceptsStent thrombosisIntracoronary stentingNon-Q-wave myocardial infarctionMajor adverse cardiac eventsNative coronary artery lesionsAdverse cardiac eventsBlunt chest traumaPrimary end pointCoronary artery lesionsNative coronary arteriesDevastating clinical consequencesBalloon-expandable stentsAspirin monotherapyAnticoagulation therapyArtery lesionsCardiac eventsChest traumaInfrequent complicationSelect patientsProcedural successRestenotic lesionsCoronary arteryOptimal stentingMyocardial infarctionClinical consequences
2001
Clinical outcome following percutaneous coronary interventions in patients with chronic renal failure
Gruberg L, Dangas G, Mehran R, Mintz GS, Kent KM, Pichard AD, Satler LF, Lansky AJ, Stone GW, Leon MB. Clinical outcome following percutaneous coronary interventions in patients with chronic renal failure. Catheterization And Cardiovascular Interventions 2001, 55: 66-72. PMID: 11793497, DOI: 10.1002/ccd.10103.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseChronic renal failurePercutaneous coronary interventionClinical outcomesLate mortalityRenal dysfunctionCoronary interventionRenal failureRenal functionRenal diseaseHigher left ventricular ejection fractionNon-Q-wave myocardial infarctionLeft ventricular ejection fractionAngiographic success rateImpaired renal functionNormal renal functionVentricular ejection fractionHospital mortalityCreatinine clearanceConsecutive patientsDiabetes mellitusEjection fractionIndependent correlatesMyocardial infarctionLarge cohortClinical outcomes of compromised side branch (stent jail) after coronary stenting with the NIR stent
Bhargava B, Waksman R, Lansky A, Kornowski R, Mehran R, Leon M. Clinical outcomes of compromised side branch (stent jail) after coronary stenting with the NIR stent. Catheterization And Cardiovascular Interventions 2001, 54: 295-300. PMID: 11747152, DOI: 10.1002/ccd.1287.Peer-Reviewed Original ResearchConceptsMyocardial infarctionSB occlusionSide branch compromiseCoronary stentingClinical outcomesStent implantationNon-Q-wave myocardial infarctionLate major adverse eventsLong-term clinical outcomesSB compromiseLate target lesion revascularizationHospital ischemic complicationsMore myocardial infarctionsNIR stent implantationMajor adverse eventsTarget lesion revascularizationSide branch occlusionSB patencyBaseline patientIschemic complicationsLesion revascularizationRepeat revascularizationAdverse eventsConsecutive patientsProcedural successDifferential Impact on Survival of Electrocardiographic Q-Wave Versus Enzymatic Myocardial Infarction After Percutaneous Intervention
Stone G, Mehran R, Dangas G, Lansky A, Kornowski R, Leon M. Differential Impact on Survival of Electrocardiographic Q-Wave Versus Enzymatic Myocardial Infarction After Percutaneous Intervention. Circulation 2001, 104: 642-647. PMID: 11489768, DOI: 10.1161/hc3101.093902.Peer-Reviewed Original ResearchConceptsQ-wave myocardial infarctionMyocardial infarctionPercutaneous interventionCPK-MB elevationNon-Q-wave myocardial infarctionElective percutaneous interventionIndependent research nurseSerial creatine phosphokinasePeriprocedural myocardial infarctionTertiary referral centerRelative prognostic importanceNew Q wavesCPK-MB levelsPowerful independent determinantCPK-MB releaseEnzymatic elevationPeriprocedural infarctionReferral centerConsecutive patientsReferral populationResearch nursesIndependent determinantsPrognostic importanceStent useQ waves
2000
Procedural results and late clinical outcomes after percutaneous interventions using long (≥25 mm) versus short (<20 mm) stents
Kornowski R, Bhargava B, Fuchs D, Lansky A, Satler L, Pichard A, Hong M, Kent K, Mehran R, Stone G, Leon M. Procedural results and late clinical outcomes after percutaneous interventions using long (≥25 mm) versus short (<20 mm) stents. Journal Of The American College Of Cardiology 2000, 35: 612-618. PMID: 10716462, DOI: 10.1016/s0735-1097(99)00580-x.Peer-Reviewed Original ResearchConceptsShort stent groupsPeriprocedural non-Q-wave myocardial infarctionNon-Q-wave myocardial infarctionCardiac event-free survivalEvent-free survivalMyocardial infarctionClinical outcomesProcedural successStent groupShort stentsHospital complicationsLesion revascularizationLong stentsOverall cardiac event-free survivalLong-term clinical outcomesQ-wave myocardial infarctionLate clinical outcomesLong stent implantationsMajor procedural complicationsMean stent lengthMore diffuse lesionsSingle-vessel interventionVessel revascularization rateOverall procedural successLong-term outcomesOptimally deployed stents in the treatment of restenotic versus de novo lesions
Gruberg L, Hong M, Mintz G, Mehran R, Waksman R, Dangas G, Kent K, Pichard A, Satler L, Lansky A, Kornowski R, Stone G, Leon M. Optimally deployed stents in the treatment of restenotic versus de novo lesions. The American Journal Of Cardiology 2000, 85: 333-337. PMID: 11078302, DOI: 10.1016/s0002-9149(99)00742-0.Peer-Reviewed Original ResearchConceptsDe novo lesionsOptimal stent deploymentTarget lesion revascularizationEvent-free survivalVein graft lesionsNovo lesionsLong-term outcomesMinimal lumen diameterRestenotic lesionsStent deploymentLesion revascularizationGraft lesionsDiabetes mellitusMyocardial infarctionHigh incidenceNon-Q-wave myocardial infarctionDe novo lesions groupFinal minimal lumen diameterLumen diameterSaphenous vein graft lesionsIndependent risk factorDe novo groupIncidence of deathStent deployment techniquesStatistical significant difference
1999
Low- versus high-dose recombinant urokinase for the treatment of chronic saphenous vein graft occlusion
Teirstein P, Mann J, Cundey P, Schechter E, Jacobs W, Grines C, Stagaman D, Lansky A, Hultquist M, Kusnick B, Heuser R, Kleinert H, Popma J. Low- versus high-dose recombinant urokinase for the treatment of chronic saphenous vein graft occlusion. The American Journal Of Cardiology 1999, 83: 1623-1628. PMID: 10392865, DOI: 10.1016/s0002-9149(99)00163-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsCerebral HemorrhageChronic DiseaseCoronary AngiographyCoronary DiseaseDose-Response Relationship, DrugFemaleGraft Occlusion, VascularHeparinHumansInfusions, IntravenousMaleMiddle AgedPlasminogen ActivatorsRecombinant ProteinsSaphenous VeinUrokinase-Type Plasminogen ActivatorConceptsSaphenous vein graftsR-UKStudy drugVein graftsMyocardial infarctionNon-Q-wave myocardial infarctionPrimary study end pointSaphenous vein graft occlusionHigh-dose armStudy end pointLife-threatening bleedingVein graft occlusionHigh-dose groupDuration of infusionRecombinant urokinaseAcceptable success rateIntracerebral bleedPercutaneous revascularizationFinal angiogramGraft occlusionRecanalization rateAngiographic analysisHuman kidney cellsAllergic reactionsLow dose
1998
Coronary Revascularization in Patients with Acute Coronary Syndromes.
Prpic R, Lansky A, Popma J. Coronary Revascularization in Patients with Acute Coronary Syndromes. Journal Of Invasive Cardiology 1998, 10 Suppl D: 22d-29d. PMID: 10762995.Peer-Reviewed Original ResearchAcute coronary syndromeCoronary revascularizationCoronary syndromeCardiac catheterizationMyocardial infarctionNon-Q-wave myocardial infarctionAtherosclerotic coronary artery diseaseElectrocardiographic ST-segment depressionEarly cardiac catheterizationRoutine coronary revascularizationExercise-induced ischemiaCardiac enzyme elevationFurther cardiac eventsST-segment depressionPrognosis of patientsCoronary artery diseaseT-wave inversionBundle branch blockCardiac eventsRecurrent painUnstable anginaArtery diseaseEnzyme elevationRecurrent hospitalizationsPatient subgroups