2013
A composite peripheral blood gene expression score has high sensitivity for obstructive coronary artery disease in a non-invasive imaging population and correlates with plaque burden and morphology by
Voros S, Thomas G, Bateman T, Mcpherson J, Lansky A, Douglas P, Ladapo J, Wingrove J, Elashoff M, Rosenberg S. A composite peripheral blood gene expression score has high sensitivity for obstructive coronary artery disease in a non-invasive imaging population and correlates with plaque burden and morphology by. European Heart Journal 2013, 34: p2413. DOI: 10.1093/eurheartj/eht308.p2413.Peer-Reviewed Original ResearchMyocardial perfusion imagingNon-calcified plaquePlaque burdenInvasive angiogramObstructive coronary artery diseaseQuantitative CTA analysisNon-diabetic patientsCoronary artery diseaseOverall plaque burdenQuantitative coronary angiographyNegative predictive valueGene expression scoreNeutrophil upregulationArtery diseaseCalcium scoreCoronary angiographyInvasive angiographyGES scoresCAD casesBlood samplesCTA analysisPatientsPerfusion imagingReferral pathsPredictive valueA Blood-Based Gene Expression Test for Obstructive Coronary Artery Disease Tested in Symptomatic Nondiabetic Patients Referred for Myocardial Perfusion Imaging The COMPASS Study
Thomas GS, Voros S, McPherson JA, Lansky AJ, Winn ME, Bateman TM, Elashoff MR, Lieu HD, Johnson AM, Daniels SE, Ladapo JA, Phelps CE, Douglas PS, Rosenberg S. A Blood-Based Gene Expression Test for Obstructive Coronary Artery Disease Tested in Symptomatic Nondiabetic Patients Referred for Myocardial Perfusion Imaging The COMPASS Study. Circulation Genomic And Precision Medicine 2013, 6: 154-162. PMID: 23418288, DOI: 10.1161/circgenetics.112.964015.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingInvasive coronary angiographyGene expression scoreCoronary angiographyNegative predictive valueNondiabetic patientsSymptomatic patientsClinical factorsPredictive valuePrespecified primary end pointObstructive coronary artery diseaseAbnormal myocardial perfusion imagingBlood-based gene expression testAdverse cardiovascular eventsPrimary end pointCoronary artery diseaseReceiver-operating characteristic curvePeripheral blood samplesReceiver-operating characteristic analysisCoronary artery disease diagnosisMaximum percent stenosisGene expression testReceiver-operating characteristicCardiovascular eventsArtery disease
2012
A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial
Lansky A, Elashoff MR, Ng V, McPherson J, Lazar D, Kraus WE, Voros S, Schwartz RS, Topol EJ. A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial. American Heart Journal 2012, 164: 320-326. PMID: 22980297, DOI: 10.1016/j.ahj.2012.05.012.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseMyocardial perfusion imagingGene expression scoreQuantitative coronary angiographyExpression scoreNondiabetic patientsArtery diseaseCardiac catheterizationCoronary angiographyBurden of CADSeverity of CADNoninvasive myocardial perfusion imagingProspective multicenter observational studyUnknown coronary artery diseaseSignificant coronary artery diseaseDiagnostic approachUnnecessary cardiac catheterizationMulticenter observational studyChest pain symptomsDiagnostic cardiac catheterizationAvailable noninvasive testsNoninvasive test resultsPositive predictive valueReliable diagnostic approach