Maggie Taylor Davis, PhD
Associate Professor of PsychiatryCards
Appointments
Contact Info
About
Titles
Associate Professor of Psychiatry
Biography
Dr. Davis is a licensed clinical psychologist and Assistant Professor in the Yale Department of Psychiatry. In July 2018 she completed a T32 funded postdoctoral fellowship (Yale Neuroimaging Sciences Training Program) under the mentorship of Dr. Irina Esterlis, and transitioned to faculty status after obtaining an NIMH funded K08 award. Her research interests center on use of molecular neuroimaging methods to enhance understanding of the relationship between suicidal behavior and stress-related psychopathology. Under her K08 award, she is investigating the relationship between availability of mGluR5 (a mostly postsynaptic glutamate receptor involved in the regulation of emotion and pain experience), borderline personality disorder (BPD) symptom presentation, and suicidal behavior. Dr. Davis is also completing a study examining in vivo kappa opioid receptor availability in BPD, and its relationship to history of suicidal behavior. Ultimately, she hopes to build of this study and similar work to craft independent lines of research investigating molecular mechanisms subserving stress-related pathology (e.g., BPD, PTSD, eating disordered behavior) and suicidal behavior in service of novel, targeted treatment development
Appointments
Psychiatry
Associate Professor on TermPrimary
Other Departments & Organizations
- Janeway Society
- MR Center
- Psychiatry
- Translational Brain Imaging Program
- Yale Instruction/Investigation/Intervention in Emotional Lability and Dysregulation (YIELD)
Education & Training
- Postdoctoral Fellow
- Yale University School of Medicine (2018)
- Predoctoral Intern
- University of Michigan/ VA Ann Arbor Healthcare System (2016)
- PhD
- Auburn University, Clinical Psychology (2016)
- MS
- Auburn University, Clinical Psychology (2013)
- BA
- University of Virginia, Psychology (2006)
Research
Overview
Medical Subject Headings (MeSH)
- View Lab Website
Yale Translational Brain Imaging Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
John Krystal, MD
Nicole DellaGioia
David Matuskey, MD
Irina Esterlis, PhD
Nabeel Nabulsi, PhD
Richard Carson, PhD
Stress Disorders, Post-Traumatic
Positron-Emission Tomography
Suicide
Trauma and Stressor Related Disorders
Pain
Publications
2024
W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders
Baldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders. Drug And Alcohol Dependence 2024, 260: 110653. DOI: 10.1016/j.drugalcdep.2023.110653.Peer-Reviewed Original ResearchDeficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, PMCID: PMC11250898, DOI: 10.1016/j.jad.2024.06.025.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5Positron emission tomographyFear processingEmotional processingAssociated with greater activationEmotion processing taskAssociated with impulsivityFunctional brain differencesAssociated with functional alterationsParietal brain regionsPathology of BDIncreased cortical activityAssociated with difficultiesDepressive disorderHealthy comparisonReceptor availabilityBrain differencesPre/postcentral gyriAttention difficultiesGreater activationBrain regionsPsychomotor functionTreatment developmentPost-traumatic change and resilience after childhood maltreatment: Impacts on maternal mental health over the postpartum period
Armer J, Oh W, Davis M, Issa M, Sexton M, Muzik M. Post-traumatic change and resilience after childhood maltreatment: Impacts on maternal mental health over the postpartum period. Journal Of Affective Disorders 2024, 361: 1-9. PMID: 38844162, DOI: 10.1016/j.jad.2024.06.010.Peer-Reviewed Original ResearchConceptsPostpartum mental healthLow symptom classMental health symptomsMental health trajectoriesChildhood maltreatmentMental healthHealth trajectoriesHealth symptomsPost-traumatic changesAssociated with reduced psychopathologyHistory of childhood maltreatmentMaternal mental healthMental health classesPost-traumatic cognitionsMental health changesAdverse postpartum outcomesPost-traumatic growthIdentification of mothersHigh-risk classMultinomial logistic regression modelLogistic regression modelsChronic high riskGeneralizability of findingsInterview measuresHealth changesPreliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders
Fan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5UF FAUncinate fasciculusFractional anisotropyWhole-brain analysisMultimodal neuroimaging approachDifferentiation of BDDiffusion-weighted MRI scansFrontotemporal dysconnectivityFrontotemporal systemFunctional dysconnectivityDepressive disorderNeurobiological mechanismsMGluR5 levelsWhite matterWhite matter abnormalitiesNeuroimaging approachesWM integrityNeural mechanismsMDDWhole-brainWM abnormalitiesReceptor 5
2020
Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression.
Lewis MW, Jones RT, Davis MT. Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression. Translational Psychiatry 2020, 10: 237. PMID: 32678079, PMCID: PMC7366706, DOI: 10.1038/s41398-020-00915-1.Peer-Reviewed Original ResearchPTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14Sex FactorsStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderPeripheral immune activationImmune activationHigher C-reactive protein levelsC-reactive protein levelsTSPO availabilityTranslocator proteinBrain microglial activationTomography brain imagingStress-related pathophysiologyPositron emission tomography (PET) brain imagingNeuroimmune activationMicroglial activationPTSD symptom severityImmunologic regulationPostmortem studiesPTSD subgroupHealthy individualsSymptom severityTrauma exposurePTSD groupStress disorderLower relative expressionBrain imagingPET imagingPredicting PTSD and Depression following Sexual Assault: The Role of Perceived Life Threat, Post-Traumatic Cognitions, Victim-Perpetrator Relationship, and Social Support
Domino, J. L., Whiteman, S. E., Weathers, F. W., Blevins, C. T., & Davis, M. T. (2020). Predicting PTSD and Depression following Sexual Assault: The Role of Perceived Life Threat, Post-Traumatic Cognitions, Victim-Perpetrator Relationship, and Social Support. Journal of Aggression, Maltreatment & Trauma, 1-19.Peer-Reviewed Original ResearchSudden unexpected death as a traumatic stressor: The impact of the DSM–5 revision of Criterion A for posttraumatic stress disorder.
Domino, J. L., Whiteman, S. E., Davis, M. T., Witte, T. K., & Weathers, F. W. (2020). Sudden unexpected death as a traumatic stressor: The impact of the DSM–5 revision of Criterion A for posttraumatic stress disorder. Traumatology.Peer-Reviewed Original Research
2019
Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET
Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsEffects of ketamineKetamine infusionGlutamate transmissionMetabotropic glutamate receptor 5Ketamine-induced effectsKetamine-induced changesGlutamate receptor 5Promising treatment targetDrug challenge studiesTwo-tissue compartment modelMGluR5 radioligandBlood pressureMGluR5 availabilityBaseline scanOutcome measuresHealthy subjectsHeart ratePsychiatric disordersReceptor 5Modulatory effectsMGluR5Treatment targetsChallenge studiesArterial input functionChallenge paradigmIn vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation
Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMGluR5 availabilitySuicidal ideationHC individualsPathophysiology of PTSDLimbic brain regionsVolume of distributionHealthy comparison controlsSuicide risk managementPositron emission tomographyReceptor 5Venous input functionsBrain regionsPTSD individualsEmission tomographyMDD individualsVivo evidenceRecent evidencePotential roleMGluR5PTSDComparison controlsDysregulationMDDIdeationIndividuals
Clinical Trials
Current Trials
Eligibility for Participation in Neuroimaging Studies
HIC ID2000027842RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsDysregulation in mGluR5 as a marker of BPD and suicide related endophenotypes
HIC ID2000023168RolePrincipal InvestigatorPrimary Completion Date10/31/2023Recruiting ParticipantsGenderBothAge18 years - 65 yearsAMPA Receptor Components of the Anti-Depressant Ketamine Response
HIC ID2000021345RoleSub InvestigatorPrimary Completion Date06/30/2032Recruiting ParticipantsGenderBothAge18 years - 65 yearsImaging mGluR5 and synaptic density in psychiatric disorders
HIC ID2000020186RoleSub InvestigatorPrimary Completion Date01/31/2018Recruiting ParticipantsGenderBothAge18 years - 80 years
Academic Achievements and Community Involvement
honor Patterson Trust Mentored Research Award
Regional AwardRobert Leet and Clara Guthrie Patterson TrustDetails02/28/2021United Stateshonor Loan Repayment Award (Clinical Research)
National AwardNIMHDetails11/01/2019United Stateshonor Early Career Investigator Travel Fellowship Award
National AwardSociety for Biological PsychiatryDetails05/17/2019United Stateshonor Yale Clinical Neuroimaging Conference Poster/ Presentation Award
Yale School of Medicine AwardYale UniversityDetails02/14/2017United States
Links & Media
News
- August 23, 2024
Microglia-Mediated Neuroimmune Suppression in PTSD Is Associated With Anhedonia
- February 23, 2021
Davis Chosen to Give Rising Star Showcase Presentation
- November 20, 2019
Yale Researchers Measure Ketamine's Effects on a Glutamate Receptor
- May 14, 2019
Biomarker Reveals PTSD Sufferers at Risk of Suicide