In-Hyun Park, PhD
Associate Professor of GeneticsDownloadHi-Res Photo
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Genetics
Primary
Child Study Center
Secondary
Additional Titles
Yale Stem Cell Center
Contact Info
Appointments
Genetics
Primary
Child Study Center
Secondary
Additional Titles
Yale Stem Cell Center
Contact Info
Appointments
Genetics
Primary
Child Study Center
Secondary
Additional Titles
Yale Stem Cell Center
Contact Info
About
Titles
Associate Professor of Genetics
Yale Stem Cell Center
Appointments
Genetics
Associate Professor TenurePrimaryChild Study Center
Associate Professor on TermSecondary
Other Departments & Organizations
Education & Training
- Post-doc Fellow
- Harvard Medical School (2009)
- PhD
- University of Illinois at Urbana-Champaign (2005)
- MS
- Seoul National University (1999)
- BS
- Seoul National University (1994)
Research
Overview
- Investigation of genetic and epigenetic regulation of reprogramming
- in vitro model of human neurodevelopmental disease
Medical Subject Headings (MeSH)
Cells; Central Nervous System Diseases; Embryonic Stem Cells; Induced Pluripotent Stem Cells; Nervous System; Neural Stem Cells; Pluripotent Stem Cells; Psychiatry and Psychology; Stem Cells
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the Park Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of In-Hyun Park's published research.
Publications Timeline
A big-picture view of In-Hyun Park's research output by year.
Research Interests
Research topics In-Hyun Park is interested in exploring.
Mei Zhong, PhD
Ferdi Kiral
Hai Feng Zhang
Jenny Huanjiao Zhou, MD, PhD
Jun Lu, PhD
Kun-Yong Kim, PhD
149Publications
18,873Citations
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Embryonic Stem Cells
Stem Cells
Neural Stem Cells
Cells
Publications
2024
Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
Kural M, Djakbarova U, Cakir B, Tanaka Y, Chan E, Arteaga Muniz V, Madraki Y, Qian H, Park J, Sewanan L, Park I, Niklason L, Kural C. Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis. Cell Death & Disease 2024, 15: 440. PMID: 38909035, PMCID: PMC11193792, DOI: 10.1038/s41419-024-06822-3.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFas-induced apoptosisCell surface Fas expressionDeath receptor FasInhibition of endocytosisSurface Fas expressionPlasma membrane tensionCancer cell apoptosisEndocytosis dynamicsApoptotic signalingReceptor FasGlioblastoma cell growthFas expressionPlasma membraneCell growthEndocytosisXenograft mouse modelSoluble FasLCell apoptosisFasApoptosisRho-kinase inhibitorCancer cellsMembrane tensionNonmalignant cellsInduce tumor regressionIdentifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids
Kim J, Park I. Identifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids. Biological Psychiatry 2024, 95: 608-610. PMID: 38479977, DOI: 10.1016/j.biopsych.2024.01.015.Peer-Reviewed Original ResearchBrain organoids: from unguided to regionalized to nucleus-specific
Xiang Y, Park I. Brain organoids: from unguided to regionalized to nucleus-specific. Life Medicine 2024, 3: lnae014. DOI: 10.1093/lifemedi/lnae014.Peer-Reviewed Original ResearchAltmetricTelencephalic organoids as model systems to study cortical development and diseases
Yang W, Kiral F, Park I. Telencephalic organoids as model systems to study cortical development and diseases. Organoid 2024, 4: e1. DOI: 10.51335/organoid.2024.4.e1.Peer-Reviewed Original Research
2023
Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon
Kiral F, Choe M, Park I. Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon. Frontiers In Cellular Neuroscience 2023, 17: 1308479. PMID: 38130869, PMCID: PMC10733522, DOI: 10.3389/fncel.2023.1308479.Peer-Reviewed Original ResearchConceptsHuman diencephalonBrain organoidsNeurodevelopmental disordersDevelopmental brain disordersHuman brain tissueThalamocortical connectionsBrain disordersDiencephalic developmentBrain tissueDiencephalic structuresOrganoid modelsHuman-specific aspectsSensory processingDiencephalonDisordersTelencephalic fatePathologyStem cellsStem cell technologyOrganoidsGENERATION OF BRAIN ORGANOIDS TO STUDY HUMAN BRAIN DEVELOPMENT AND DISEASES
Yang W, Park I. GENERATION OF BRAIN ORGANOIDS TO STUDY HUMAN BRAIN DEVELOPMENT AND DISEASES. IBRO Neuroscience Reports 2023, 15: s48. DOI: 10.1016/j.ibneur.2023.08.2149.Peer-Reviewed Original ResearchScalable production of tissue-like vascularized liver organoids from human PSCs
Harrison S, Siller R, Tanaka Y, Chollet M, de la Morena-Barrio M, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud K, Lunov O, Dejneka A, Mowinckel M, Stavik B, Sandset P, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson S, Skottvoll F, Boger I, Bogen I, Nyman T, Wu J, Bezrouk A, Cizkova D, Corral J, Mokry J, Zweigerdt R, Park I, Sullivan G. Scalable production of tissue-like vascularized liver organoids from human PSCs. Experimental & Molecular Medicine 2023, 55: 2005-2024. PMID: 37653039, PMCID: PMC10545717, DOI: 10.1038/s12276-023-01074-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExtracellular matrixSingle-cell RNA sequencingBasic developmental biologyEmbryonic liver developmentPost-translational modificationsLiver-like functionsCostly growth factorsOrganoid modelsKey liver functionsCellular diversityCellular repertoireDevelopmental biologyCellular complexityN-glycosylationRNA sequencingDe novo vascularizationNumber of tissuesProtein productionSerum protein productionLiver developmentHuman PSCsDrug toxicity assessmentOrganoidsSmall moleculesGrowth factorFemale naïve human pluripotent stem cells carry X chromosomes with Xa-like and Xi-like folding conformations
Patterson B, Yang B, Tanaka Y, Kim K, Cakir B, Xiang Y, Kim J, Wang S, Park I. Female naïve human pluripotent stem cells carry X chromosomes with Xa-like and Xi-like folding conformations. Science Advances 2023, 9: eadf2245. PMID: 37540754, PMCID: PMC10403202, DOI: 10.1126/sciadv.adf2245.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNaïve human pluripotent stem cellsHuman pluripotent stem cellsX-chromosome inactivationX chromosomePluripotent stem cellsStem cellsNaïve human embryonic stem cellsX chromosome stateX chromosome statusInactive X chromosomeActive X chromosomeHuman embryonic stem cellsEarly embryonic cellsEmbryonic stem cellsUnique epigenetic regulationChromatin compactionGenomic resolutionEpigenetic regulationChromosome inactivationChromosome stateSomatic cellsEmbryonic cellsChromosomesChromosome statusCellsGeneration of ventralized human thalamic organoids with thalamic reticular nucleus
Kiral F, Cakir B, Tanaka Y, Kim J, Yang W, Wehbe F, Kang Y, Zhong M, Sancer G, Lee S, Xiang Y, Park I. Generation of ventralized human thalamic organoids with thalamic reticular nucleus. Cell Stem Cell 2023, 30: 677-688.e5. PMID: 37019105, PMCID: PMC10329908, DOI: 10.1016/j.stem.2023.03.007.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman embryonic stem cellsSingle-cell RNA sequencingReceptor tyrosine protein kinaseTyrosine protein kinaseEmbryonic stem cellsDisease-associated genesLineage developmentRNA sequencingHuman brain developmentOrganoid systemsStem cellsHuman brain organoidsNeuronal functionBrain organoidsOrganoidsBrain organoid systemsDistinct nucleiBrain developmentThalamic developmentPTCHD1NucleusKinaseGenesSequencingMutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation
Sun J, Osenberg S, Irwin A, Ma L, Lee N, Xiang Y, Li F, Wan Y, Park I, Maletic-Savatic M, Ballas N. Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation. Cell Reports 2023, 42: 111942. PMID: 36640327, PMCID: PMC10857774, DOI: 10.1016/j.celrep.2022.111942.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMECP2 mutationsTranscriptional regulator MeCP2Rett syndromeTranscriptional landscapeTranscriptional changesDysfunctional mitochondriaHuman astrocytesAstrocyte gene expressionGene expressionMECP2 geneMolecular signaturesMutationsPost-natal maturationMaturationDevelopmental maturationBrain bioenergeticsMolecular featuresFunctional maturationStellate morphologyMature morphologyMetabolic aberrationsHuman-based modelsAstrocytesKey roleNeurodevelopmental disorders
News
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- September 19, 2023
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- October 28, 2022
Dr. Betty Hsiao Receives Rheumatology Research Foundation’s Innovative Research Grant
- February 02, 2022Source: YaleNews
Ally and Enemy? Yale Scientists Explore Immune Cell Suspect in Alzheimer’s
- January 17, 2022
Jonas to Study Bipolar Disorder
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10 Amistad Street, Ste 214J
New Haven, CT 06519
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203.737.5173
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