Graeme Mason, PhD
Professor of Radiology and Biomedical Imaging and of PsychiatryCards
About
Titles
Professor of Radiology and Biomedical Imaging and of Psychiatry
Director Metabolic Modeling and Director Psychiatric MRS, Magnetic Resonance Research Center; Director, Neuroimaging Sciences Training Program, Radiology & Biomedical Imaging and Psychiatry; Chair, Magnetic Resonance Research Center Protocol Review Committee, Radiology & Biomedical Imaging
Biography
Dr. Graeme F. Mason develops experimental models and methods for studies of brain metabolism using 1H and 13C Nuclear Magnetic Resonance (NMR) and Mass Spectrometry in conjunction with 13C isotopic labeling in vivo, in cell preparations, and other systems. His work began during his graduate studies at Yale where he used a rat model for the experimental determination of brain glucose transport kinetics, energetics, and neurotransmitter metabolism. Dr. Mason received further training at the University of Alabama at Birmingham, where he guided the group's 13C-labeling studies of the human brain in vivo in the 4.1T whole-body MR system. Dr. Mason studies metabolism and neurotransmission in the brain in vivo, including effects of psychiatric, neurological, and metabolic conditions. Dr. Mason examines healthy subjects and patients to investigate relationships among GABA, glutamate, and glutamine concentrations and their rates of synthesis and release in the brain, in particular with regard to effects of acute and chronic use of alcohol. He also studies detailed kinetic modeling of isotopomer and isotopologues using data from high-resolution NMR and mass spectrometry.
Appointments
Radiology & Biomedical Imaging
ProfessorPrimaryPsychiatry
ProfessorSecondary
Other Departments & Organizations
- Division of Neurocognition, Neurocomputation & Neurogenetics
- Bioimaging Sciences
- Center for Biomedical Data Science
- Center for Brain & Mind Health
- Center for Nicotine and Tobacco Use Research at Yale (CENTURY)
- Center for the Translational Neuroscience of Alcohol
- Diabetes Research Center
- Magnetic Resonance Research Center
- Magnetic Resonance Spectroscopy
- Neuroimaging Sciences Training Program
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Radiology & Biomedical Imaging
- Radiology Diversity Program
- Yale Ventures
Education & Training
- Postdoctoral Fellow
- University of Alabama at Birmingham, Center for Nuclear Imaging Research, Birmingham, AL (1994)
- Postdoctoral Research Associate
- Yale University, New Haven, CT (1993)
- PhD
- Yale University (1991)
- Graduate Study
- Yale University, New Haven, CT (1991)
- Research Assistant
- Hershey Medical Center, Hershey, PA (1986)
- BS
- The Pennsylvania State University, Nuclear Engineering, Minor in Spanish (1986)
Research
Overview
Dr. Mason's research integrates quantitative approaches to measure functional brain chemistry and the study of diabetes, metabolic syndrome, and neuropsychiatric disorders. The primary methods used are 1H and 13C magnetic resonance spectroscopy, with some studies using mass spectrometry, as well as the mathematical assessment of metabolism. Current areas of research include alcohol effects, depression, alcoholism, and post-traumatic stress disorder. His primary areas of interest are the effects of alcohol on the brain, and to that end, his research evaluates acute and chronic effects of alcohol and its oxidation on the brain, from the perspectives of neurotransmission, metabolism, adaptation, and vulnerability to dependence.
Medical Subject Headings (MeSH)
Academic Achievements and Community Involvement
Links & Media
News
- August 12, 2024
Yale Conference for Alcohol Research and Education 2024: Call for Abstracts
- November 07, 2023
Alcohol Research Conference Fosters Collaboration Across Specialties
- September 19, 2023
Investigators Launch Study Aimed at Accelerating Understanding of Bipolar Disorder
- June 05, 2023
Sinha Elected Vice President; Mason on Board of Research Society on Alcohol