Yifan Wang, MD, MS
Hospital ResidentCards
About
Research
Publications
2025
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
Grippin A, Marconi C, Copling S, Li N, Braun C, Woody C, Young E, Gupta P, Wang M, Wu A, Jeong S, Soni D, Weidert F, Xie C, Goldenberg E, Kim A, Zhao C, DeVries A, Castillo P, Lohray R, Rooney M, Schrank B, Wang Y, Ma Y, Chang E, Kouzy R, Dyson K, Jafarnia J, Nariman N, Gladish G, New J, Argueta A, Amaya D, Thomas N, Doty A, Chen J, Copling N, Alatrash G, Simon J, Davies A, Dennis W, Liang R, Lewis J, Wei X, Rinsurongkawong W, Vaporciyan A, Johns A, Lee J, Lee J, Sun R, Sharma P, Tran H, Zhang J, Gibbons D, Wargo J, Kim B, Heymach J, Mendez-Gomez H, Jiang W, Sayour E, Lin S. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. Nature 2025, 647: 488-497. PMID: 41125896, PMCID: PMC12611756, DOI: 10.1038/s41586-025-09655-y.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsSARS-CoV-2 mRNA vaccinesPD-L1 expressionImmunologically cold tumorsMRNA vaccinesType I interferonPD-L1Cold tumorsSARS-CoV-2Sensitizing tumors to immune checkpoint inhibitorsTumors to immune checkpoint blockadeThree-year overall survivalCD8+ T cellsI interferonImmune checkpoint blockadeTumor-associated antigensMRNA cancer vaccinesInnate immune cellsCheckpoint blockadeCheckpoint inhibitorsICI treatmentCancer vaccinesOverall survivalPersonalized vaccinesPreclinical modelsImbalance of habit-based versus goal-directed learning in internet gaming disorder: evidence from fMRI and behavioral performance
Zheng H, Ma X, Wang M, Wang Z, Lu C, Dong G. Imbalance of habit-based versus goal-directed learning in internet gaming disorder: evidence from fMRI and behavioral performance. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 142: 111524. PMID: 41086991, DOI: 10.1016/j.pnpbp.2025.111524.Peer-Reviewed Original ResearchConceptsInternet gaming disorderRecreational game usersInferior frontal gyrusBehavioral performanceFrontal gyrusGaming disorderMaintenance of addictive behaviorsLeft inferior frontal gyrusRight inferior frontal gyrusInternet gaming disorder groupPrefrontal-striatal circuitsInstrumental learning taskInstrumental learning processesLeft precentral gyrusAddiction severity scoresGoal-directed actionsGoal-directed learningBilateral lingual gyrusFunctional MRI dataNeurocognitive mechanismsAddiction severityHabitual controlAddictive behaviorsBilateral precuneusLingual gyrusExploring the heterogeneity of internet gaming disorder: a stage-based framework characterized by evolving euphoria and compulsivity
Kang M, Xu L, Zhang J, Song K, Wang Z, Fang X, Bowden-Jones H, Pallanti S, Zhang J. Exploring the heterogeneity of internet gaming disorder: a stage-based framework characterized by evolving euphoria and compulsivity. Addictive Behaviors 2025, 171: 108457. PMID: 40902308, DOI: 10.1016/j.addbeh.2025.108457.Peer-Reviewed Original ResearchConceptsInternet gaming disorderCross-sectional definitionsPsychometric propertiesInternet gaming disorder symptomsInternet Gaming Disorder ScaleMeasures of cravingClinical staging approachLatent profile analysisLatent transition analysisOne-year stabilityDSM-5Disorder ScaleICD-11Factor structureGaming disorderCore phenotypeLife satisfactionCompulsionStratified interventionsEuphoriaTransition analysisYoung adultsProfile analysisDisordersCravingEfficacy of traditional Chinese medicine prescription in treatment of COVID-19: A prospective cohort study
Huang F, Zhou Y, Jiang C, Wang Y, Cheng J, Lin X, Chen L, Peng C, Pan G, Chen X, Yin L, Chai K. Efficacy of traditional Chinese medicine prescription in treatment of COVID-19: A prospective cohort study. Medicine 2025, 104: e43285. PMID: 40696615, PMCID: PMC12282704, DOI: 10.1097/md.0000000000043285.Peer-Reviewed Original ResearchConceptsDays 2 to 4Prospective cohort studyClinical symptomsDays 0 to 1TCM groupConventional treatmentCohort studyPoor appetiteMulticenter prospective cohort studyDays 6 to 8Symptoms of feverMann-Whitney U testClinical symptoms of COVID-19TCM prescriptionsSymptoms of COVID-19Treatment regimensCOVID-19 inpatientsCOVID-19Treatment of COVID-19Treatment of coronavirus diseaseMann-WhitneyU testPrescriptionControl groupChinese medicine prescriptionTargeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma (Adv. Sci. 22/2025)
Khorsandi S, Huntoon K, Wang Y, Woodward A, Antony A, Endsley C, Hafeez N, Edwards J, McCuen N, Alluri P, Kim B, Jiang W, Lux J. Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma (Adv. Sci. 22/2025). Advanced Science 2025, 12 DOI: 10.1002/advs.202570173.Peer-Reviewed Original ResearchExamining the spectrum of problematic online behaviors in Chinese adolescents: A network analysis of smartphone, gaming, and social media use
Zhang S, Tao S, Zhang Y, Zhou J, Wei J, Chen M, Hu Q, Zheng H, Wang Z. Examining the spectrum of problematic online behaviors in Chinese adolescents: A network analysis of smartphone, gaming, and social media use. Computers In Human Behavior 2025, 167: 108611. DOI: 10.1016/j.chb.2025.108611.Peer-Reviewed Original ResearchNetwork community detectionUsage of smartphonesOnline behaviorSocial networking sitesCommunity detectionVideo gamesSocial media useSmartphoneSocial networksNetworking sitesNetworkRapid development of digital technologiesRapid developmentNetwork analysisDevelopment of digital technologiesMedia useDigital eraSmartphone useGameA Generative Artificial Intelligence Copilot for Biomedical Nanoengineering
Wang Y, Song H, Teng Y, Huang G, Qian J, Wang H, Dong S, Ha J, Ma Y, Chang M, Jeong S, Deng W, Schrank B, Grippin A, Wu A, Edwards J, Zhang Y, Lin Y, Poon W, Wilhelm S, Bi Y, Teng L, Wang Z, Kim B, Jiang W. A Generative Artificial Intelligence Copilot for Biomedical Nanoengineering. ACS Nano 2025, 19: 19394-19407. PMID: 40367350, DOI: 10.1021/acsnano.5c03454.Peer-Reviewed Original ResearchConceptsArtificial intelligenceNatural language processing tasksExtract contextual informationLanguage processing tasksAutomatically extract knowledgeAI-based methodsGenerative artificial intelligenceInformation extractionLanguage modelAutomated learningContextual informationProcessing tasksIntelligent copilotBaseline modelAI toolsDesign tasksTaskQueryScientific queriesAutomaticallyCopilotIntelligenceScientific researchLLMLearningTargeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma
Khorsandi S, Huntoon K, Wang Y, Woodward A, Antony A, Endsley C, Hafeez N, Edwards J, McCuen N, Alluri P, Kim B, Jiang W, Lux J. Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma. Advanced Science 2025, 12: 2416596. PMID: 40135812, PMCID: PMC12165055, DOI: 10.1002/advs.202416596.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsStimulator of interferon genesMurine modelCytosol of antigen-presenting cellsSuccess of immune checkpoint inhibitorsMurine model of breast cancerMurine model of melanomaImmune responseModel of breast cancerSTING activationActivation of stimulator of interferon genesAntigen-presenting cellsModel of melanomaT cell deathCheckpoint inhibitorsAdvanced melanomaOverall survivalClinical responseTumor sizeT cellsAntitumor effectBreast cancerProinflammatory pathwaysCurative resultsImmune regulationAn antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy
Schrank B, Wang Y, Wu A, Tran N, Lee D, Edwards J, Huntoon K, Dong S, Ha J, Ma Y, Grippin A, Jeong S, Antony A, Chang M, Kang M, Gallup T, Koong A, Li J, Yun K, Kim B, Jiang W. An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy. Nature Cancer 2025, 6: 511-527. PMID: 40000910, PMCID: PMC11952976, DOI: 10.1038/s43018-025-00919-0.Peer-Reviewed Original ResearchConceptsAntibody-toxin conjugatesTumor cellsImmune recognition of tumor cellsEnhanced antigen cross-presentationRecognition of tumor cellsCancer cell phagocytosisTumor-derived antigensToxin listeriolysin OTumor-derived peptidesImproved animal survivalPromote immune recognitionCytosolic immune sensorsIntracellular bacterium Listeria monocytogenesTreatment in vivoTreating multiple cancersPhagocytosis checkpointsCheckpoint blockadeCancer immunotherapySignal CD47Listeriolysin OMetastatic breastMelanoma tumorsTherapeutic strategiesAnimal survivalCell phagocytosisA Multidisciplinary Multimodal Aligned Dataset for Academic Data Processing
Song H, Xu H, Wang Z, Wang Y, Li J. A Multidisciplinary Multimodal Aligned Dataset for Academic Data Processing. Scientific Data 2025, 12: 172. PMID: 39881139, PMCID: PMC11779955, DOI: 10.1038/s41597-025-04415-z.Peer-Reviewed Original ResearchData processingResearch trend analysisCitation recommendationCaption generationModel-based techniquesTextual dataAlignment datasetsProcessing capabilitiesDatasetVisual elementsScholarly articlesValidation methodPeer-reviewed scholarly articlesScientometricsSCImagoBibliometricsMetadataBenchmarksCitationsCountry/region distributionVisualizationResearch endeavorsAccuracyResearch prospectsCapability
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