Yifan Wang, MD, MS
Hospital ResidentCards
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Research
Publications
2025
An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy
Schrank B, Wang Y, Wu A, Tran N, Lee D, Edwards J, Huntoon K, Dong S, Ha J, Ma Y, Grippin A, Jeong S, Antony A, Chang M, Kang M, Gallup T, Koong A, Li J, Yun K, Kim B, Jiang W. An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy. Nature Cancer 2025, 6: 511-527. PMID: 40000910, DOI: 10.1038/s43018-025-00919-0.Peer-Reviewed Original ResearchConceptsAntibody-toxin conjugatesTumor cellsImmune recognition of tumor cellsEnhanced antigen cross-presentationRecognition of tumor cellsCancer cell phagocytosisTumor-derived antigensToxin listeriolysin OTumor-derived peptidesImproved animal survivalPromote immune recognitionCytosolic immune sensorsIntracellular bacterium Listeria monocytogenesTreatment in vivoTreating multiple cancersPhagocytosis checkpointsCheckpoint blockadeCancer immunotherapySignal CD47Listeriolysin OMetastatic breastMelanoma tumorsTherapeutic strategiesAnimal survivalCell phagocytosisA Multidisciplinary Multimodal Aligned Dataset for Academic Data Processing
Song H, Xu H, Wang Z, Wang Y, Li J. A Multidisciplinary Multimodal Aligned Dataset for Academic Data Processing. Scientific Data 2025, 12: 172. PMID: 39881139, PMCID: PMC11779955, DOI: 10.1038/s41597-025-04415-z.Peer-Reviewed Original ResearchData processingResearch trend analysisCitation recommendationCaption generationModel-based techniquesTextual dataAlignment datasetsProcessing capabilitiesDatasetVisual elementsScholarly articlesValidation methodPeer-reviewed scholarly articlesScientometricsSCImagoBibliometricsMetadataBenchmarksCitationsCountry/region distributionVisualizationResearch endeavorsAccuracyResearch prospectsCapability
2024
Multi-omics approaches to decipher the interactions of nanoparticles and biological systems
Wang Y, Xiao Z, Wang Z, Lee D, Ma Y, Wilhelm S, Wang H, Kim B, Jiang W. Multi-omics approaches to decipher the interactions of nanoparticles and biological systems. Nature Reviews Bioengineering 2024, 1-16. DOI: 10.1038/s44222-024-00264-4.Peer-Reviewed Original ResearchMulti-omics approachNano-bio interactionsMulti-omicsMulti-omics pipelineMulti-omics dataSubcellular levelHigh-throughput mannerApplication of transcriptomicsNanoparticles in vivoMetabolomics technologyTreatment strategiesNanoparticle uptakeBiological systemsOptimized nanoparticlesEngineered nanoparticlesBiological informationImplementation of nanoparticlesClinical settingInteraction of nanoparticlesCell typesNano-bio interfaceEpigenomeTranscriptomeMetabolomicsBioinformaticsLearning what keeps nanomedicines in tumours
Wang Y, Schrank B, Jiang W, Kim B. Learning what keeps nanomedicines in tumours. Nature Biomedical Engineering 2024, 8: 1330-1331. PMID: 39271934, DOI: 10.1038/s41551-024-01251-1.Peer-Reviewed Original ResearchUnderstanding nanoparticle-liver interactions in nanomedicine
He Y, Wang Y, Wang L, Jiang W, Wilhelm S. Understanding nanoparticle-liver interactions in nanomedicine. Expert Opinion On Drug Delivery 2024, 21: 829-843. PMID: 38946471, PMCID: PMC11281865, DOI: 10.1080/17425247.2024.2375400.Peer-Reviewed Original ResearchConceptsLiver Kupffer cellsNanoparticle physicochemical propertiesEnhanced delivery efficiencyAdministered nanoparticlesEffective nanomedicinesKupffer cellsLiver diseasePhagocytic functionClinical translationHepatic diseaseLiver accumulationClinical applicationNanomedicineDelivery efficiencyLiverPhagocytic roleDiseaseSynthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells
Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong S, Link T, Gallup T, Qie Y, Li X, Dong S, Schrank B, Grippin A, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong A, Tainer J, Jiang W, Kim B. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nature Biomedical Engineering 2024, 8: 593-610. PMID: 38641710, PMCID: PMC11162332, DOI: 10.1038/s41551-024-01194-7.Peer-Reviewed Original ResearchAntigen-presenting cellsInnate immune pathwaysImmune pathwaysPriming of effector T cellsImmune checkpoint inhibitorsAntitumour immune responseEffector T cellsIntracellular DNA-sensing pathwaysMetastatic breast cancerSyngeneic mouse modelMultiple innate immune pathwaysAdaptive immunogenicityAntitumour responseCheckpoint inhibitorsEndoplasmic reticulum stressT cellsSystemic clearanceBreast cancerDNA-sensing pathwayRelease of mitochondrial DNATherapeutic advantageMouse modelImmune responseEfficient primingIntracellular deliveryPlasma MERTK Is a Promising Biomarker for the Diagnosis and Prognosis of Hepatitis B Virus–Related Acute-on-Chronic Liver Failure
Lu Y, Xin J, Liang X, Luo J, Li P, Zhou X, Yang H, Li J, Wang Y. Plasma MERTK Is a Promising Biomarker for the Diagnosis and Prognosis of Hepatitis B Virus–Related Acute-on-Chronic Liver Failure. The Journal Of Infectious Diseases 2024, 230: 957-969. PMID: 38373244, DOI: 10.1093/infdis/jiae079.Peer-Reviewed Original ResearchHBV-ACLF patientsChronic hepatitis BAcute-on-chronic liver failureMer tyrosine kinaseHBV-ACLFArea under the receiver operating characteristic curveNormal controlsLiver failureLiver cirrhosisHBV-related acute-on-chronic liver failurePrognosis of HBV-ACLFHepatitis B-related acute-on-chronic liver failureRisk stratification analysesReceiver operating characteristic curveCut-off valueShort-term mortalityPrognostic rolePrognostic significancePrognostic valueHepatitis BPoor prognosisMerTK expressionImmunohistochemistry stainingDiagnostic accuracyDisease progression
2023
Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity.
Li X, Huntoon K, Wang Y, Lee D, Dong S, Antony A, Walkey C, Kim B, Jiang W. Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity. Molecular Cancer Therapeutics 2023, 23: 330-342. PMID: 37956421, DOI: 10.1158/1535-7163.mct-23-0236.Peer-Reviewed Original ResearchTumor growth inhibitionDendritic cellsAnti-PD-1 checkpoint inhibitorsAntigen-specific T cellsIL-2/ILGreater tumor infiltrationImmune stimulatory mechanismsMurine breast cancer modelAntitumor immune responseCombination of radiotherapyInnate immune activationType I interferon productionImmune-modulatory propertiesIL-15 receptorBreast cancer modelI interferon productionSuperior tumor growth inhibitionGrowth inhibitionInterferon genes (STING) pathwaySystemic immunotherapyWestern blot analysisCheckpoint inhibitorsMetastatic settingAntitumor immunitySurvival benefitAge-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics
Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank B, Ha J, Kang M, Yang M, Gong P, Lorenzi P, Tan L, Gallup T, Tang S, Yang Z, Li J, Sanford N, Wang H, Kim B, Jiang W. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nature Nanotechnology 2023, 19: 255-263. PMID: 37723279, DOI: 10.1038/s41565-023-01502-3.Peer-Reviewed Original ResearchConceptsCancer nanotherapeuticsCancer nanomedicineScavenger receptor MARCOPhagocytic clearanceUptake of nanoparticlesAntitumour responseTumor deliveryTherapeutic blockadeAntitumour efficacyAge-associated decreaseHepatic phagocytesAntitumour effectsYoung miceHepatic macrophagesAged miceTreatment outcomesTreat multiple human diseasesProtein level analysisHepatic uptakeAge-related declineNon-human primatesNanotherapeuticsMiceNanomedicinePhagocytic uptakeIntradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
You Y, Tian Y, Yang Z, Shi J, Kwak K, Tong Y, Estania A, Cao J, Hsu W, Liu Y, Chiang C, Schrank B, Huntoon K, Lee D, Li Z, Zhao Y, Zhang H, Gallup T, Ha J, Dong S, Li X, Wang Y, Lu W, Bahrani E, Lee L, Teng L, Jiang W, Lan F, Kim B, Lee A. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nature Biomedical Engineering 2023, 7: 887-900. PMID: 36635419, DOI: 10.1038/s41551-022-00989-w.Peer-Reviewed Original ResearchConceptsExtracellular vesiclesTranslation of genetic materialFunctional proteinsGenetic materialIntradermal deliveryRNA therapeuticsPhotoaged skinHuman dermal fibroblastsType I collagenMessenger RNA therapeuticsProtein replacement therapyTreatment of photoaged skinCOL1A1 mRNAVesiclesMRNADermal fibroblastsTissues of miceEncapsulated mRNAReduced wrinkle formationProteinTherapyDelivery systemReplacement of collagenMicroneedle arraysCollagen
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