Lorenzo Galluzzi
Assistant Professor AdjunctCards
About
Research
Publications
2025
T cell exhaustion: early or late in tumour progression?
Galluzzi L. T cell exhaustion: early or late in tumour progression? Nature Reviews Immunology 2025, 1-2. PMID: 40038448, DOI: 10.1038/s41577-025-01158-1.Peer-Reviewed Original ResearchProceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation
Morris Z, Demaria S, Monjazeb A, Formenti S, Weichselbaum R, Welsh J, Enderling H, Schoenfeld J, Brody J, McGee H, Mondini M, Kent M, Young K, Galluzzi L, Karam S, Theelen W, Chang J, Huynh M, Daib A, Pitroda S, Chung C, Serre R, Grassberger C, Deng J, Sodji Q, Nguyen A, Patel R, Krebs S, Kalbasi A, Kerr C, Vanpouille-Box C, Vick L, Aguilera T, Ong I, Herrera F, Menon H, Smart D, Ahmed J, Gartrell R, Roland C, Fekrmandi F, Chakraborty B, Bent E, Berg T, Hutson A, Khleif S, Sikora A, Fong L. Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation. The Lancet Oncology 2025, 26: e152-e170. PMID: 40049206, DOI: 10.1016/s1470-2045(24)00656-9.Peer-Reviewed Original ResearchConceptsAnti-tumor immune responseDelivery of radiotherapyTumor immune recognitionSelection of immunotherapyBiomarker-guided approachesNational Cancer Institute workshopClinical trial dataImmunotherapy combinationsClinical responseImprove patient outcomesPreclinical modelsPatient selectionRadiotherapyImmunotherapyClinical endpointsClinical dataClinical studiesImmune recognitionImmune responseImmune effectsAnimal studiesClinical translationPatient outcomesTrial dataNegative trialsMitochondrial succinate feeds T cell exhaustion in cancer
Galluzzi L, Guilbaud E, Garg A. Mitochondrial succinate feeds T cell exhaustion in cancer. Cancer Cell 2025, 43: 168-170. PMID: 39933894, DOI: 10.1016/j.ccell.2025.01.005.Peer-Reviewed Original ResearchParadoxical control of multifocal mammary oncogenesis by radiation therapy
Galluzzi L, Buqué A. Paradoxical control of multifocal mammary oncogenesis by radiation therapy. OncoImmunology 2025, 14: 2458886. PMID: 39873285, PMCID: PMC11776481, DOI: 10.1080/2162402x.2025.2458886.Peer-Reviewed Original ResearchAnimal models of disease: Achievements and challenges
Bravo-San Pedro J, Aranda F, Buqué A, Galluzzi L. Animal models of disease: Achievements and challenges. Methods In Cell Biology 2025, 192: xv-xxi. PMID: 39863396, DOI: 10.1016/s0091-679x(25)00026-3.Peer-Reviewed Original ResearchEpigenetic regulation of cancer
Galluzzi L, Spada S. Epigenetic regulation of cancer. International Review Of Cytology 2025, 390: xiii-xvii. PMID: 39864898, DOI: 10.1016/s1937-6448(25)00015-2.Peer-Reviewed Original ResearchCirculating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer
Galluzzi L, Spada S. Circulating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer. International Review Of Cytology 2025, 391: xiii-xvii. PMID: 39939080, DOI: 10.1016/s1937-6448(25)00031-0.Peer-Reviewed Original Research
2024
Targeting CDK2 to circumvent treatment resistance in HR+ breast cancer
Arrizabalaga L, García-Torralba E, Galluzzi L, Buqué A. Targeting CDK2 to circumvent treatment resistance in HR+ breast cancer. Trends In Molecular Medicine 2024 PMID: 39732571, DOI: 10.1016/j.molmed.2024.12.009.Peer-Reviewed Original ResearchTargeting immune evasion in hepatocellular carcinoma-initiating cells
Sirera R, Beltrán-Visiedo M, Galluzzi L. Targeting immune evasion in hepatocellular carcinoma-initiating cells. Trends In Immunology 2024, 46: 4-6. PMID: 39721855, DOI: 10.1016/j.it.2024.12.002.Peer-Reviewed Original ResearchA novel pharmacological entity toward integrated multimodal immunotherapy
Sirera R, Beltrán-Visiedo M, Galluzzi L. A novel pharmacological entity toward integrated multimodal immunotherapy. Trends In Pharmacological Sciences 2024, 46: 95-97. PMID: 39721827, DOI: 10.1016/j.tips.2024.12.001.Peer-Reviewed Original Research