Laura Yoviene Sykes, PhD
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Featured Publications
The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis
Laura A. Yoviene Sykes, Nina Levine, Sümeyra N. Tayfur, Toni Gibbs-Dean, Hadar Hazan, Shannon Imetovski, Josina James, Sneha Karmani, Walter S. Mathis, Philip Markovich, Deepa Purushothaman, Sarah Riley, Cenk Tek, Carrie Veillette, John D. Cahill, Julienne Giard, Amy Marracino, Kyle Barrette, Stephanie Bozak, Francis Gregory, Glen McDermott, Vinod H. Srihari, The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis, Schizophrenia Research, Volume 278, 2025, Pages 96-108, ISSN 0920-9964, https://doi.org/10.1016/j.schres.2025.03.029.Peer-Reviewed Original ResearchThe effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service
Ferrara M, Guloksuz S, Hazan H, Li F, Tek C, Sykes L, Riley S, Keshavan M, Srihari V. The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service. Schizophrenia Research 2023, 260: 198-204. PMID: 37688984, DOI: 10.1016/j.schres.2023.08.005.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesLength of stayUntreated psychosisPsychiatric hospitalizationFirst-episode servicesDuration of hospitalizationIncidence rate ratiosNon-affective psychosisNew Haven areaPoisson regression modelsPatient characteristicsHospitalization ratesRecent onsetMedical recordsHospitalizationEffect of durationNegative binomial regressionSpecialized treatmentPsychosisRate ratioBinomial regressionAdmissionDUPEnrollmentFirst yearFirst-episode psychosis and autism spectrum disorder: a scoping review and a guide to overcome diagnostic challenges
Ferrara, M, Curtarello, E., Simonelli, S., Yoviene Sykes, L.A., Fusar-Poli, L., Folesani, F., Belvederi, M. Murri, Eugenio Aguglia, E., Politi, P & Grassi, L (2023) First-episode psychosis and autism spectrum disorder: a scoping review and a guide to overcome diagnostic challenges, International Journal of Mental Health, DOI: 10.1080/00207411.2023.2276872Peer-Reviewed Original ResearchReducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial
Srihari, V.H., Ferrara, M., Li, F., Kline, E., Gülöksüz, S., Pollard, J.M., Cahill, J.D., Mathis, W.S. Yoviene Sykes, L.A., Walsh, B.C., McDermott, G., Seidman, L.J., Gueorguieva, R., Woods, S.W., Tek, C, & Keshavan, M.S. Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial, Schizophrenia Bulletin Open, Volume 3, Issue 1, January 2022, sgab057, https://doi.org/10.1093/schizbullopen/sgab057Peer-Reviewed Original ResearchTaking the next step: Improving care transitions from a first‐episode psychosis service
Gallagher, K, Ferrara, M, Pollard, J, Yoviene Sykes, L.A., Li, F., Imetovski, S., Cahill, J.D., Mathis, W., & Srihari, V.H. Taking the next step: Improving care transitions from a first‐episode psychosis service. Early Intervention in Psychiatry. 2021; 1– 6. https://doi.org/10.1111/eip.13127Peer-Reviewed Original ResearchPredictive validity of conversion from the clinical high risk syndrome to frank psychosis
Yoviene Sykes LA, Ferrara M, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woodberry KA, Powers AR, Ponce AN, Cahill JD, Pollard JM, Srihari VH, Woods SW. Predictive validity of conversion from the clinical high risk syndrome to frank psychosis. Schizophrenia Research 2019, 216: 184-191. PMID: 31864837, PMCID: PMC7239715, DOI: 10.1016/j.schres.2019.12.002.Peer-Reviewed Original ResearchConceptsFrank psychosisFirst-episode psychosis patientsOne-yearNorth American Prodromal Longitudinal StudySeverity of illnessClinical high-risk syndromeCurrent antipsychotic medicationsHigh-risk syndromePsychosis risk syndromeClinical high riskPredictive validityFEP casesPrescription ratesAntipsychotic medicationPsychosis patientsRisk syndromePsychosis onsetHigh riskLittle investigative attentionDiagnostic stabilityCHR individualsPsychosis paradigmPsychosisLongitudinal studySyndromeAddressing concerns in psychology training: Consultation on trainee development
Ponce, A.N., Aosved, A.C., Yoviene Sykes, L. A, Davis III, C., & Teng, E.J. (2019). Addressing concerns in psychology training: Consultation on trainee development. Training and Education in Professional Psychology, 13 (4), 247-253.Peer-Reviewed Original Research
2025
The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC)
Hazan H, Tayfur S, Zhou B, Li F, Gibbs-Dean T, Karmani S, Kline E, Ferrara M, Corbera S, Riley S, Sykes L, Tek C, Keshavan M, Srihari V. The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC). PLOS ONE 2025, 20: e0312740. PMID: 39928579, PMCID: PMC11809850, DOI: 10.1371/journal.pone.0312740.Peer-Reviewed Original ResearchConceptsCoordinated specialty careQuality of lifeDuration of untreated psychosisDUP groupWorld Health OrganizationYear of coordinated specialty careGeneralized linear modelConfidence intervalsBinary outcomesGlobal functioningDuration of untreated psychosis groupSymptom severityUntreated psychosisSpecialty careCSC programsImpact of duration of untreated psychosisFunctional gainsModel repeated measuresMixed model repeated measuresOdds ratioNo significant differenceLogit link functionStatus improvementContinuous outcomesSocial functioning
2023
Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis
Hagler M, Ferrara M, Yoviene Sykes L, Li F, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Mathalon D, Seidman L, Tsuang M, Walker E, Powers A, Allen A, Srihari V, Woods S. Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis. Schizophrenia Research 2023, 255: 239-245. PMID: 37028205, PMCID: PMC10207144, DOI: 10.1016/j.schres.2023.03.047.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesClinical high riskClinical high-risk individualsEarly detectionFirst-episode psychosis individualsRecent psychiatric hospitalizationCourse of illnessHigh-risk individualsAttenuated positive symptomsCHR researchGeographic catchmentSyndromal psychosisPsychosis individualsPsychiatric hospitalizationEarly intervention effortsHigh riskPsychosis servicesPositive symptomsGlobal functioningClinical resourcesProtective factorsDifferent populationsFE participantsGeneralizability of findingsFES program
2022
Corrigendum to: Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial
Srihari V, Ferrara M, Li F, Kline E, Gülöksüz S, Pollard J, Cahill J, Mathis W, Sykes L, Walsh B, McDermott G, Seidman L, Gueorguieva R, Woods S, Tek C, Keshavan M. Corrigendum to: Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial. Schizophrenia Bulletin Open 2022, 3: sgac020. PMID: 39144776, PMCID: PMC11206056, DOI: 10.1093/schizbullopen/sgac020.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News & Links
How Mindmap is Helping Young People Experiencing Symptoms of Psychosis
Dr. Laura Yoviene Sykes, PhD, Assistant Professor of Psychiatry at Yale School of Medicine, and Dr. Craig Allen, Medical Director at Rushford Center were featured on Connecticut's Morning Buzz to discuss the Mindmap initiative, in honor of World Schizophrenia Awareness Day and Mental Health Awareness Month.
Media
NBC Live! Collaborating with LMHAs for Early Detection of Psychosis
Dr. Yoviene Sykes was featured on NBC Live to discuss STEP's collaboration with LMHAs for Early Detection efforts across the state.
How Mindmap is Helping Young People Experiencing Symptoms of Psychosis
Dr. Laura Yoviene Sykes, PhD, Assistant Professor of Psychiatry at Yale School of Medicine, and Dr. Craig Allen, Medical Director at Rushford Center were featured on Connecticut's Morning Buzz to discuss the Mindmap initiative, in honor of World Schizophrenia Awareness Day and Mental Health Awareness Month.
MindmapCT Featured on Connecticut’s Morning Buzz
The Mindmap campaign is expanding statewide across Connecticut. Connecticut’s Morning Buzz Host Natasha Lubczenko was joined in the studio by Dr. Laura Yoviene Sykes, PhD and Dr. Vinod Srihari, MD, from the Yale School of Medicine’s STEP Learning Collaborative Program to discuss this important campaign, designed to educate and empower the public on first episode psychosis.
Reducing Barriers to Treatment for Young People Experiencing Psychosis in CT
Video by RedRock BrandingSTEP Learning Collaborative Director Laura Yoviene Sykes, PhD talks about the how the STEP Learning Collaborative aims to reduce barriers to care.
About the Mindmap CT Psychosis Awareness Campaign
Dr. Laura Yoviene Sykes Ph.D. Director of the STEP LC discusses the statewide expansion of the Mindmap Early Detection campaign
News
- July 03, 2024
James Named Director of Social Work for STEP Learning Collaborative
- March 27, 2024Source: WTNH News
Mindmap featured on WTNH
- February 13, 2024Source: WNPR
Mindmap 2.0 on Connecticut Public Radio
- February 13, 2024
Mindmap Launches Statewide Campaign to Support Early Detection of First-episode Psychosis in Teens and Young Adults
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