Janghoo Lim, PhD

Professor of Genetics and Neuroscience; co-Director of Graduate Studies, Genetics

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Appointments

Genetics

Fully Joint

Neuroscience

Fully Joint

Contact Info

janghoo.lim@yale.edu

203.737.6268

Additional Titles

co-Director of Graduate Studies, Genetics

About

Titles

Professor of Genetics and Neuroscience; co-Director of Graduate Studies, Genetics

co-Director of Graduate Studies, Genetics

Biography

Janghoo Lim received his undergraduate and master’s degrees in South Korea. He completed his Ph.D. and postdoctoral training at Baylor College of Medicine in Houston, Texas. He joined Yale in 2010 and is currently a Professor in the Departments of Genetics and of Neuroscience.

Last Updated on July 02, 2025.

Appointments

Genetics
Professor
Fully Joint
Genetics
Neuroscience
Professor
Fully Joint
Neuroscience

Genetics
Human Genome Sciences
Interdepartmental Neuroscience Program
Molecular Cell Biology, Genetics and Development
Neural Disorders
Neuroscience
Neuroscience Track
Program in Cellular Neuroscience, Neurodegeneration and Repair
Wu Tsai Institute
Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Yale Stem Cell Center
Yale Ventures

Education & Training

PhD: Baylor College of Medicine (2004)

MS: Korea Advanced Institute of Science and Technology, Daejeon, Korea (1999)

BS: Chonnam National University, Gwangju, Korea (1997)

Research

Overview

Medical Research Interests

Developmental Disabilities; Mental Disorders; Motor Neuron Disease; Neurodegenerative Diseases; Neuromuscular Diseases; Spinocerebellar Ataxias

ORCID
0000-0002-5331-210X
The Lim Lab at Yale
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Research at a Glance

Yale Co-Authors

Frequent collaborators of Janghoo Lim's published research.

Leon Tejwani, PhD
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View 11 Common Publications
Youngseob Jung
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David van Dijk, PhD, MSc, BSc
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Diane Krause, MD, PhD
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Siyuan (Steven) Wang, PhD
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Publications

2026

Locus‐Specific Genetic Associations at the DAOA Gene in Schizophrenia and Bipolar Disorder
Khalid M, Mukhtar M, Saqlain M, Sami A, Baig S, Nawaz A, Moeez S, Ayaz C, Fatima T, Fatima F, Lim J, Nawaz M, Raja G. Locus‐Specific Genetic Associations at the DAOA Gene in Schizophrenia and Bipolar Disorder. Advanced Genetics 2026, 7: e00064. PMID: 42466100, PMCID: PMC13374824, DOI: 10.1002/ggn2.202500064.
Peer-Reviewed Original Research
PGC-1α pathway dysregulation disrupts myofiber specification in a mouse model of SBMA
Kuo C, Chopp L, Yu Z, Ni L, Zhao H, Lim J, Lieberman A. PGC-1α pathway dysregulation disrupts myofiber specification in a mouse model of SBMA. JCI Insight 2026, 11: e203215. PMID: 42096288, PMCID: PMC13461168, DOI: 10.1172/jci.insight.203215.
Peer-Reviewed Original Research
Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1
Lee C, Grijalva R, Tejwani L, Bae E, Chase A, Ro H, Kim H, Olmos V, Orengo J, Lim J. Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1. Journal Of Clinical Investigation 2026, 136: e195723. PMID: 42113962, PMCID: PMC13262716, DOI: 10.1172/jci195723.
Peer-Reviewed Original Research
MeSH Keywords

2025

Targeting the mutant androgen receptor with PROTACs in spinal and bulbar muscular atrophy
Lee C, Lim J. Targeting the mutant androgen receptor with PROTACs in spinal and bulbar muscular atrophy. Neurotherapeutics 2025, 22: e00771. PMID: 41107106, PMCID: PMC12664553, DOI: 10.1016/j.neurot.2025.e00771.
Peer-Reviewed Original Research
Peripherally administered androgen receptor-targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model
Lee C, Yu Z, Kuo C, Tejwani L, Grijalva R, Bae E, Zhao H, Lim J, Lieberman A. Peripherally administered androgen receptor-targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model. Journal Of Clinical Investigation 2025, 135: e182955. PMID: 40875460, PMCID: PMC12578385, DOI: 10.1172/jci182955.
Peer-Reviewed Original Research

2023

Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1
Tejwani L, Ravindra N, Lee C, Cheng Y, Nguyen B, Luttik K, Ni L, Zhang S, Morrison L, Gionco J, Xiang Y, Yoon J, Ro H, Haidery F, Grijalva R, Bae E, Kim K, Martuscello R, Orr H, Zoghbi H, McLoughlin H, Ranum L, Shakkottai V, Faust P, Wang S, van Dijk D, Lim J. Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1. Neuron 2023, 112: 362-383.e15. PMID: 38016472, PMCID: PMC10922326, DOI: 10.1016/j.neuron.2023.10.039.
Peer-Reviewed Original Research
Dysregulation of alternative splicing in spinocerebellar ataxia type 1
Olmos V, Thompson E, Gogia N, Luttik K, Veeranki V, Ni L, Sim S, Chen K, Krause D, Lim J. Dysregulation of alternative splicing in spinocerebellar ataxia type 1. Human Molecular Genetics 2023, 33: 138-149. PMID: 37802886, PMCID: PMC10979408, DOI: 10.1093/hmg/ddad170.
Peer-Reviewed Original Research
MeSH Keywords
Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration
Tejwani L, Jung Y, Kokubu H, Sowmithra S, Ni L, Lee C, Sanders B, Lee P, Xiang Y, Luttik K, Soriano A, Yoon J, Park J, Ro H, Ju H, Liao C, Tieze S, Rigo F, Jafar-Nejad P, Lim J. Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. Journal Of Clinical Investigation 2023, 133: e138207. PMID: 37384409, PMCID: PMC10425213, DOI: 10.1172/jci138207.
Peer-Reviewed Original Research
MeSH Keywords

2022

A Novel Missense Mutation in ERCC8 Co-Segregates with Cerebellar Ataxia in a Consanguineous Pakistani Family
Gauhar Z, Tejwani L, Abdullah U, Saeed S, Shafique S, Badshah M, Choi J, Dong W, Nelson-Williams C, Lifton RP, Lim J, Raja GK. A Novel Missense Mutation in ERCC8 Co-Segregates with Cerebellar Ataxia in a Consanguineous Pakistani Family. Cells 2022, 11: 3090. PMID: 36231052, PMCID: PMC9564319, DOI: 10.3390/cells11193090.
Peer-Reviewed Original Research
MeSH Keywords
Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex
Luttik K, Olmos V, Owens A, Khan A, Yun J, Driessen T, Lim J. Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex. Cells 2022, 11: 2632. PMID: 36078042, PMCID: PMC9454518, DOI: 10.3390/cells11172632.
Peer-Reviewed Original Research
MeSH Keywords

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Academic Achievements & Community Involvement

Honors

honor
Blavatnik Development Award
03/01/2026Yale University AwardBlavatnik Family Foundation
Details
honor
Blavatnik Accelerator Award
07/02/2025Yale University AwardBlavatnik Family Foundation
Details
honor
Young Investigator Award for SCA Research
01/01/2014International AwardNational Ataxia Foundation
Details
honor
Child Health Research Award
06/05/2012Regional AwardCharles H. Hood Foundation
Details
honor
Sloan Research Fellowship
02/15/2012International AwardAlfred P. Sloan Foundation
Details

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News

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Get In Touch

Contacts

janghoo.lim@yale.edu

Academic Office Number

203.737.6268

Lab Number

203.737.6267

Locations

100 College Street
Lab
Rm 330
New Haven, CT 06510
Appointments
203.737.6267
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Events

Nov 202630Monday

Yale Only
1:00 PM2:00 PM
Grace Zou - Ayushi Hegde
Genetics Research-In-Progress (RIP)
Hope Memorial Building
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Dec 20267Monday

Everyone
12:00 PM1:00 PM
Andrew Liebrman, MD/PhD
Neuroscience Seminar Series: Deconstructing Polyglutamine-mediated Neuromuscular Degeneration
100 College Street
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Appointments

Contact Info

Additional Titles

Titles

Biography

Appointments

Genetics

Neuroscience

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

ORCID

The Lim Lab at Yale

Research at a Glance

Yale Co-Authors

Leon Tejwani, PhD

Youngseob Jung

David van Dijk, PhD, MSc, BSc

Diane Krause, MD, PhD

Siyuan (Steven) Wang, PhD

Publications

2026

2025

2023

2022

Honors

Blavatnik Development Award

Blavatnik Accelerator Award

Young Investigator Award for SCA Research

Child Health Research Award

Sloan Research Fellowship

News

2025 Yale-KU Forum: Clinical and Basic Neuroscience

Eight Translational Biotech Projects Selected for 2025 Blavatnik Accelerator Awards

From the journals

The Most Popular Neuroscience Stories of 2023

Contacts

Locations

100 College Street

Events

Genetics Research-In-Progress (RIP)

Neuroscience Seminar Series: Deconstructing Polyglutamine-mediated Neuromuscular Degeneration