Dustin Scheinost, PhD, BS
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
Featured Publications
Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences
Rodriguez R, Noble S, Camp C, Scheinost D. Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences. Nature Neuroscience 2025, 28: 2601-2611. PMID: 41184631, PMCID: PMC12641774, DOI: 10.1038/s41593-025-02099-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingResting-state functional magnetic resonance imagingResting-state dataCoactivation patternsFunctional connectivityResting-state signalsBrain's intrinsic functional architectureResting-state functional connectivityIntrinsic functional architectureTask activation patternsTask fMRI dataHigh identifiersFMRI dataLarge-scale neuroimaging datasetsConnectomeFunctional architectureNeuroimaging datasetsActivity patternsTask dataMagnetic resonance imagingTaskResonance imagingPhenotypic measurementsConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkBrain age prediction and deviations from normative trajectories in the neonatal connectome
Sun H, Mehta S, Khaitova M, Cheng B, Hao X, Spann M, Scheinost D. Brain age prediction and deviations from normative trajectories in the neonatal connectome. Nature Communications 2024, 15: 10251. PMID: 39592647, PMCID: PMC11599754, DOI: 10.1038/s41467-024-54657-5.Peer-Reviewed Original ResearchConceptsPostmenstrual agePerinatal periodBrain age predictionFunctional connectomeMonths of postnatal lifeMonths of lifePreterm infantsNormative trajectoryConnectome-based predictive modelingThird trimesterPerinatal exposureBrain age gapPostnatal lifeResting-state fMRIInfantsHuman Connectome ProjectNeonatal connectomeDevelopmental trajectoriesBrainBehavioral outcomesNormative dataMonthsConnectome ProjectDTI dataConnectomeThe tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research
Noble S, Curtiss J, Pessoa L, Scheinost D. The tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research. Imaging Neuroscience 2024, 2: imag-2-00138. PMID: 40740614, PMCID: PMC12247580, DOI: 10.1162/imag_a_00138.Peer-Reviewed Original Research
2026
Optimizing functional connectivity scanning conditions for predicting autistic traits
Horien C, Mandino F, Greene A, Shen X, Powell K, Vernetti A, O’Connor D, Adkinson B, Tejavibulya L, McPartland J, Volkmar F, Chun M, Chawarska K, Lake E, Rosenberg M, Satterthwaite T, Scheinost D, Finn E, Constable R. Optimizing functional connectivity scanning conditions for predicting autistic traits. Nature Mental Health 2026, 4: 792-805. PMID: 42137910, PMCID: PMC13167459, DOI: 10.1038/s44220-026-00623-7.Peer-Reviewed Original ResearchSustained attention taskAutistic traitsAttention taskConnectome-based predictive modelingAutism Brain Imaging Data ExchangeBrain-phenotype relationshipsScanning conditionsMagnetic resonance imaging-based studiesMeasures of attentionSocial attention taskOptimal brain stateMeasure of social responsibilityHealthy Brain NetworkSample of youthResting-state conditionNeurobiological correlatesAttentional challengesNeurotypical adultsNeurotypical participantsBrain networksAutistic featuresBrain statesAutismClinically relevant phenotypesImaging-based studiesFeature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers
Adkinson B, Rosenblatt M, Sun H, Dadashkarimi J, Tejavibulya L, Horien C, Westwater M, Rodriguez R, Noble S, Scheinost D. Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers. Nature Human Behaviour 2026, 1-15. PMID: 41986741, DOI: 10.1038/s41562-026-02447-y.Peer-Reviewed Original ResearchNeurobiological interpretationNeurobiological basisBrain-behavior associationsBrain connectivity dataHuman neuroimagingPsychiatric phenotypesBehavioral phenotypesFunctional MRIFunctional connectivityNeuroimaging dataMental healthLarge-scale neuroimaging datasetsConnectivity dataNeuroimaging datasetsNeurobiologyMRI studiesNeuroimagingExternal validationCognitionConnectomeGeneralizabilityParticipantsLatent classes of sleep deficiency and correlates among patients receiving methadone treatment: A longitudinal study
Hsaio C, Jeon S, DiMeola K, Walker K, Akhiwu O, Stein M, Madden L, Redeker N, Scheinost D, Fiellin D, Yaggi H, Barry D. Latent classes of sleep deficiency and correlates among patients receiving methadone treatment: A longitudinal study. Addiction 2026 PMID: 41852290, DOI: 10.1111/add.70384.Peer-Reviewed Original ResearchPositive urine toxicologyUrine toxicologyMethadone treatmentTreatment continuationPain interferencePain interference with sleepClass IIIClass ILate sleepObstructive sleep apneaOne-year treatment outcomesUrine toxicology resultsSleep deficiencyClass II-IVRestless legs syndromeEpworth Sleepiness ScaleRestless Legs Syndrome QuestionnairePatient-completed questionnairesSTOP questionnaireSleep apneaInterfere with sleepOpioid treatment programsClinical characteristicsPsychological symptomsMedical chartsHigh-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER
Mehta S, Sun H, Micali N, Holden D, Fowles K, Rossano S, Zhang J, Ma C, Han P, Lee W, Duque A, Rakic P, Groman S, Carson R, Scheinost D, Toyonaga T. High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 0271678x261429044. PMID: 41823342, PMCID: PMC12987752, DOI: 10.1177/0271678x261429044.Peer-Reviewed Original ResearchDistribution volume ratioMaternal brainIn vivo markerFetal brainPET imagingSynaptic developmentPregnant rhesus macaquesRegional distribution volume ratiosMarker of synaptic densitySynaptic vesicle glycoprotein 2APET scannerNon-invasive toolNonhuman primate brainPET quantificationBrain-dedicated PET scannersNeuroExplorerRhesus macaquesSynaptic densityBiograph mCTOccipital lobeOccipital regionBrainMotion correctionPETPrimate brainShared and Unique Connectivity Signatures of Reading and Language Deficits
Daucourt M, Rosenblatt M, Frijters J, Bosson-Heenan J, Gruen J, Scheinost D. Shared and Unique Connectivity Signatures of Reading and Language Deficits. Journal Of Cognitive Neuroscience 2026, 38: 575-597. PMID: 40991681, PMCID: PMC12898692, DOI: 10.1162/jocn.a.98.Peer-Reviewed Original ResearchConnectome-based predictive modelingLanguage comprehensionTests of word readingPsychometric testsCPM modelsLarge-scale functional connectivity patternsLanguage comprehension difficultiesBrain-behavior relationshipsMultiple cognitive skillsCognitive Development StudyAssociated with readingFunctional connectivity dataFunctional connectivity patternsFunctional connectivity measuresBrain basisWord readingAdolescent brainLanguage deficitsFrontal networkComprehension difficultiesLanguage abilityLanguage difficultiesConnectivity signaturesReading abilityNeuroimaging dataUsing Fetal, Infant, and Toddler Neuroimaging to Understand Brain Changes After Prenatal Exposure to Opioids
Scheinost D, Spann M. Using Fetal, Infant, and Toddler Neuroimaging to Understand Brain Changes After Prenatal Exposure to Opioids. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2026, 11: 259-260. PMID: 41794415, DOI: 10.1016/j.bpsc.2026.01.003.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Connectivity While Coming of Age
IRB ID2000028368RoleSub InvestigatorPrimary Completion Date12/31/2026Recruiting ParticipantsGenderBothAge18 years - 25 yearsBrain Imaging Study of Emotion Regulation in Children
IRB ID2000031303RoleSub InvestigatorPrimary Completion Date11/30/2023Recruiting ParticipantsGenderBothAge5 years - 15 yearsStudying the Adult Brain
IRB ID2000025671RoleSub InvestigatorPrimary Completion Date07/31/2025Recruiting ParticipantsGenomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)
IRB ID2000020449RoleSub InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsGenderBothAge8+ yearsLinks Between Newborn Brain Connectivity and Social Development
IRB ID2000021541RoleSub InvestigatorPrimary Completion Date08/31/2023Recruiting ParticipantsGenderBothAgeUp to 1 year 9 months
News
News
- April 15, 2026
Overlooked Brain Connections Hold Clues to Cognition and Mental Health
- January 13, 2026
More Than Just Fear: A New Profile of Post-traumatic Stress Disorder
- December 01, 2025
From the Journals
- November 12, 2025
Twenty-Seven YSM Faculty Members Recognized for Highly Cited Research
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