2016
Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell’Anno M, Gulden FO, Pochareddy S, Tebbenkamp AT, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports 2016, 16: 2576-2592. PMID: 27568284, PMCID: PMC5135012, DOI: 10.1016/j.celrep.2016.08.038.Peer-Reviewed Original ResearchMeSH KeywordsAxl Receptor Tyrosine KinaseBrainCell DeathCentrosomeFetusGene Expression ProfilingHumansImmunity, InnateMicrocephalyMitochondriaMitosisNeocortexNeural Stem CellsNeuroepithelial CellsNeurogliaNeuronsNeuroprotective AgentsNucleosidesPhosphorylationProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSpinal CordTranscription, GeneticVirus ReplicationZika VirusZika Virus InfectionConceptsRadial glial cellsNES cellsNeuroepithelial stem cellsZIKV infectionFetal brain slicesStem cellsEarly human neurodevelopmentHuman neuroepithelial stem cellsHuman neural stem cellsCell deathSingle-cell RNA-seqNeural stem cellsNeurodevelopment defectsZIKV replicationGlial cellsBrain slicesPotential treatmentRadial gliaZika virusPhospho-TBK1Neurodevelopmental defectsRNA-seqSupernumerary centrosomesNucleoside analoguesHuman neurodevelopment
2006
RanBPM Contributes to Semaphorin3A Signaling through Plexin-A Receptors
Togashi H, Schmidt EF, Strittmatter SM. RanBPM Contributes to Semaphorin3A Signaling through Plexin-A Receptors. Journal Of Neuroscience 2006, 26: 4961-4969. PMID: 16672672, PMCID: PMC2846289, DOI: 10.1523/jneurosci.0704-06.2006.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell Adhesion MoleculesCell DeathCell SizeCells, CulturedChick EmbryoCloning, MolecularCricetinaeCricetulusCytoskeletal ProteinsDose-Response Relationship, DrugDrug InteractionsEnzyme InhibitorsGanglia, SpinalGene ExpressionGreen Fluorescent ProteinsHumansImmunoprecipitationIn Situ Nick-End LabelingNerve Tissue ProteinsNeuritesNeuronsNeuropilin-1Nuclear ProteinsRan GTP-Binding ProteinSemaphorin-3ASignal TransductionTranscription Factor AP-1TransfectionTwo-Hybrid System TechniquesConceptsPlexin-A1Collapsin response mediator proteinsNervous system developmentReceptor complex consistingSignal transductionRanBPMMediator proteinsMicrotubule functionCell spreadingComplex consistingAxonal guidanceNeuronal cellsAxonal guidance cuesProteinGuidance cuesPlexinsAxonal outgrowthExpressionSema3ATransductionReceptorsDomainOverexpressionNeuropilinsSystem development
1999
Excitotoxic Death of a Subset of Embryonic Rat Motor Neurons In Vitro
Fryer HJ, Knox RJ, Strittmatter SM, Kalb RG. Excitotoxic Death of a Subset of Embryonic Rat Motor Neurons In Vitro. Journal Of Neurochemistry 1999, 72: 500-513. PMID: 9930721, DOI: 10.1046/j.1471-4159.1999.0720500.x.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalciumCalcium ChannelsCalcium Channels, L-TypeCell Culture TechniquesCell DeathCells, CulturedDizocilpine MaleateDose-Response Relationship, DrugExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFemaleGlutamic AcidGlutamineGlycineKainic AcidMembrane PotentialsMotor NeuronsNerve Tissue ProteinsNeurotoxinsN-MethylaspartatePotassiumPregnancyRatsRats, Sprague-DawleyReceptors, AMPAReceptors, Kainic AcidReceptors, N-Methyl-D-AspartateSpinal CordConceptsGlutamate receptor agonistsMotor neuronsReceptor agonistNon-NMDA glutamate receptor agonistsIntracellular Ca2Agonist-evoked intracellular Ca2Specific glutamate receptor agonistsIonotropic glutamate receptor activationReceptor subtype-specific antagonistsSpinal cord motor neuronsSubtype-specific antagonistsCultured motor neuronsGlutamate receptor expressionRat motor neuronsMost motor neuronsGlutamate receptor activationL-type Ca2Subunit-specific antibodiesTime-dependent mannerReceptor phenotypeChannel antagonistsReceptor expressionNeurotoxic effectsRoute of entryExtracellular Ca2