1987
Angiotensin converting enzyme immunohistochemistry in rat brain and pituitary gland: Correlation of isozyme type with cellular localization
Strittmatter SM, Snyder SH. Angiotensin converting enzyme immunohistochemistry in rat brain and pituitary gland: Correlation of isozyme type with cellular localization. Neuroscience 1987, 21: 407-420. PMID: 3039401, DOI: 10.1016/0306-4522(87)90131-x.Peer-Reviewed Original ResearchConceptsAngiotensin converting enzymeSubstantia nigraRat brainChoroid plexusPituitary glandPosterior pituitaryConverting enzymePituitary stalk sectionEntopeduncular nucleusSubfornical organCaudate putamenGlobus pallidusEnzyme immunoreactivityParaventricular nucleusAnterior pituitaryAngiotensinEnzyme inhibitorsPosterior lobeIntense stainingCell bodiesMonoclonal antibodiesDiffuse stainingEndothelial cellsEnzyme immunohistochemistryAntibody specificity
1986
Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme.
Strittmatter SM, Lynch DR, Snyder SH. Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme. Brain Research 1986, 394: 207-15. PMID: 3021286, DOI: 10.1016/0165-3806(86)90096-9.Peer-Reviewed Original ResearchConceptsBasal gangliaAdult ratsChoroid plexusEnkephalin convertaseAdult levelsRat brain peptidasesExpression of ACEWeeks of ageBrain peptidasesStriatonigral systemAcid autoradiographyPerinatal periodPostnatal weekRat brainDifferential ontogenyPostnatal developmentPrenatal expressionMost neuropeptidesAngiotensinHigh concentrationsThalamusGangliaBirthPlexusRatsDifferential ontogeny of rat brain peptidases: Prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme
Strittmatter S, Lynch D, Snyder S. Differential ontogeny of rat brain peptidases: Prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme. Brain Research 1986, 29: 207-215. DOI: 10.1016/0165-3806(86)90096-9.Peer-Reviewed Original ResearchBasal gangliaAdult ratsChoroid plexusEnkephalin convertaseAdult levelsRat brain peptidasesExpression of ACEWeeks of ageBrain peptidasesStriatonigral systemAcid autoradiographyPerinatal periodPostnatal weekRat brainDifferential ontogenyPostnatal developmentPrenatal expressionMost neuropeptidesAngiotensinHigh concentrationsThalamusGangliaBirthPlexusRats
1985
Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography
Javitch JA, Strittmatter SM, Snyder SH. Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography. Journal Of Neuroscience 1985, 5: 1513-1521. PMID: 4009243, PMCID: PMC6565258, DOI: 10.1523/jneurosci.05-06-01513.1985.Peer-Reviewed Original ResearchConceptsDA uptake sitesNE uptake sitesUptake sitesRat brainSubstantia nigra pars compactaAnterior olfactory nucleusVentral tegmental areaIbotenic acid lesionsAnteroventral thalamusNoradrenergic terminalsOlfactory nucleusSolitary tractMazindol bindingPars compactaSomatodendritic regionOlfactory tubercleDopaminergic axonsLocus coeruleusNorepinephrine uptakeTegmental areaPeriventricular nucleusSubthalamic nucleusIbotenic acidStria terminalisAcid lesionsParkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.
Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 2173-2177. PMID: 3872460, PMCID: PMC397515, DOI: 10.1073/pnas.82.7.2173.Peer-Reviewed Original ResearchConceptsDopamine neuronsCortical synaptosomesParkinsonism-inducing neurotoxinNigrostriatal dopamine neuronsCerebral cortical synaptosomesMetabolite N-methylNorepinephrine uptake systemMetabolite of MPTPPotency of drugsIdiopathic parkinsonismStriatal synaptosomesClinical abnormalitiesMonoamine oxidase BNucleus accumbensRat brainRat striatumDopamine uptakeMPTPN-methylSelective destructionSynaptosomesNeuronsOxidase BTetrahydropyridineSelective toxicity
1984
Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons.
Lynch DR, Strittmatter SM, Snyder SH. Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6543-6547. PMID: 6436816, PMCID: PMC391961, DOI: 10.1073/pnas.81.20.6543.Peer-Reviewed Original ResearchConceptsEnkephalin convertaseSpinal trigeminal tractDorsal parabrachial nucleusTrigeminal tractSolitary tractAcid autoradiographySubstantia gelatinosaParabrachial nucleusDentate gyrusLocus coeruleusPreoptic hypothalamusInterpeduncular nucleusLateral septumBed nucleusRat brainStria terminalisMedian eminenceMagnocellular nucleusCentral nucleusImmunocytochemical localizationHypothalamusEnkephalin biosynthesisEnkephalinTractGuanidinoethylmercaptosuccinic acidAutoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.
Strittmatter SM, Lo MM, Javitch JA, Snyder SH. Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1599-1603. PMID: 6324207, PMCID: PMC344885, DOI: 10.1073/pnas.81.5.1599.Peer-Reviewed Original ResearchConceptsCaudate putamenSubstantia nigraStriatonigral pathwayRat brainAngiotensin II involvementIpsilateral caudate putamenTrans-synaptic changesIpsilateral substantia nigraMedian preoptic areaAngiotensin-converting enzymeLack of effectStriatal interneuronsAngiotensin IIEntopeduncular nucleusNeuronal perikaryaSubfornical organZona reticulataGlobus pallidusACE activityLocus coeruleusParaventricular nucleusPreoptic areaIbotenic acidMedial habenulaNeuronal pathways