2019
Mitochondrial DNA stress signalling protects the nuclear genome
Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Mitochondrial DNA stress signalling protects the nuclear genome. Nature Metabolism 2019, 1: 1209-1218. PMID: 32395698, PMCID: PMC7213273, DOI: 10.1038/s42255-019-0150-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCell NucleusCytosolDNA DamageDNA, MitochondrialDNA-Binding ProteinsGenomeHigh Mobility Group ProteinsInterferonsInterferon-Stimulated Gene Factor 3Membrane ProteinsMiceMice, KnockoutMice, NudeNF-kappa BNucleotidyltransferasesProtein Serine-Threonine KinasesSignal TransductionConceptsMtDNA stressNuclear DNAGene expressionThousands of copiesMost cell typesRepair responseAcute antiviral responseNuclear genomeCircular mtDNAHigher-order structureInterferon gene expressionEssential proteinsMitochondrial DNACultured primary fibroblastsDNA stressUnphosphorylated formInterferon-stimulated gene expressionMouse melanoma cellsNDNA repairSignaling responseOxidative phosphorylationNDNA damageMtDNA damageMtDNAPrimary fibroblasts
2001
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
Peretz S, Jensen R, Baserga R, Glazer P. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1676-1681. PMID: 11172010, PMCID: PMC29316, DOI: 10.1073/pnas.98.4.1676.Peer-Reviewed Original ResearchConceptsWild-type cellsIGF-IR promoter activityAT cellsAtaxia telangiectasiaPromoter activityLevel of transcriptionHeterologous viral promotersDominant negative fragmentTyrosine kinase activityCell surface receptorsATM cDNAIGF-IR expressionIGF-IRInhibition of apoptosisATM functionAT syndromeKinase activityViral promotersCDNA resultsCell transformationInsulin-like growthATM geneSurface receptorsGrowth abnormalitiesExtreme radiosensitivity