Helene Benveniste, MD, PhD
Anthony N. Brady Professor of AnesthesiologyCards
Appointments
Additional Titles
Vice Chair of Research, Anesthesiology
Contact Info
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
Appointments
Additional Titles
Vice Chair of Research, Anesthesiology
Contact Info
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
Appointments
Additional Titles
Vice Chair of Research, Anesthesiology
Contact Info
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
About
Copy Link
Titles
Anthony N. Brady Professor of Anesthesiology
Vice Chair of Research, Anesthesiology
Biography
Dr. Benveniste is a Professor of Anesthesiology at Yale. She received her Bachelors degree in Mathematics & Physics from Katedralskolen, Denmark, and went on to study at the University of Copenhagen, where she received her MD in 1989 and PhD (Doctor Medicinae) in 1991. As a Research Fellow, she trained in high field magnetic resonance imaging (MRI) at Duke University Medical Center with Dr. G. Allen Johnson and developed techniques for brain imaging focused on neurodegenerative disease processes, including Alzheimer’s Disease. She went on to pursue her internship training in Family Medicine and her residency in Anesthesiology also at Duke University. Dr. Benveniste joined the faculty of Duke University's department of Anesthesiology in 1996, where she continued her work in developing diagnostic MRI based platforms for early detection of AD.
In 2001 Dr. Benveniste joined the department of Anesthesiology at Stony Book Medical Center as faculty and set up a preclinical MRI facility at Brookhaven National Laboratory; PET technology was integrated into her work to measure the bioavailability and pharmacokinetics of psychoactive compounds and anesthetic drugs. In 2015, Dr. Benveniste’s laboratory became involved with studies of the ‘glymphatic pathway’ which is a novel peri-vascular based system in the central nervous system involved in brain waste removal. Dr. Benveniste has received national and international recognition for her work. In November of 2016, Benveniste moved to Yale University, where she joined the Department of Anesthesiology and is expanding her research program in understanding how the glymphatic system and cerebrospinal fluid transport is affected in neurodegenerative disease states and aging.
Appointments
Anesthesiology
ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Copenhagen, Neurobiology (1991)
- MD
- University of Copenhagen (1986)
Research
Copy Link
Overview
Medical Research Interests
ORCID
0000-0002-2887-6667
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Sunil Koundal
Jean-Leon Thomas, PhD
Douglas Rothman, PhD
D. S. Fahmeed Hyder, PhD
Kevin Behar, PhD
Zachary Gursky, PhD
Brain
Central Nervous System
Cerebrospinal Fluid
Anesthesia
Publications
2025
Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model
Gursky Z, Khan Z, Koundal S, Bhardwaj A, Melgarejo J, Xu K, Chen X, Lin H, Gu X, Lee H, Kipnis J, Dori Y, Tannenbaum A, Santambrogio L, Benveniste H. Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model. Journal Of Clinical Investigation 2025, 135: e182555. PMID: 40663395, PMCID: PMC12404751, DOI: 10.1172/jci182555.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDeep cervical lymph nodesLymph nodesContrast-enhanced magnetic resonance imagingDynamic contrast-enhanced magnetic resonance imagingCervical lymph nodesEvidence of hydrocephalusBlood-brain barrier leakageImpaired lymphatic drainageLow-grade inflammationLymphatic drainage pathwaysCerebral homeostasisMagnetic resonance imagingDCE-MRILymphatic drainageIntracranial pressureLymphatic vesselsMeningeal lymphatic vesselsLong-term mechanical stressResonance imagingBarrier leakageRatsSolute clearanceGlymphatic influxDrainage pathwaysAge groupsFluid and Waste Clearance in Central Nervous System Health and Diseases
Kamouh M, Lenck S, Lehericy S, Benveniste H, Thomas J. Fluid and Waste Clearance in Central Nervous System Health and Diseases. Neurodegenerative Diseases 2025, 1-22. PMID: 40334649, PMCID: PMC12173435, DOI: 10.1159/000546018.Peer-Reviewed Original ResearchCitationsAltmetricReduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsDoes semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial)
Klausen M, Kuzey T, Pedersen J, Justesen S, Rasmussen L, Knorr U, Mason G, Ekstrøm C, Holst J, Koob G, Benveniste H, Volkow N, Knudsen G, Vilsbøll T, Fink-Jensen A. Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial). BMJ Open 2025, 15: e086454. PMID: 39779270, PMCID: PMC11749217, DOI: 10.1136/bmjopen-2024-086454.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAlcohol use disorderUse disorderGamma-aminobutyric acidComorbid obesityAlcohol cue reactivityCognitive behavioral therapyHeavy drinking daysWhite matter tract integrityBrain gamma-aminobutyric acidGlucagon-like peptide-1Alcohol consumptionMental health disordersReduce alcohol consumptionClinical trialsCue reactivityPlacebo-controlled clinical trialBehavioral therapyDrinking daysFunctional connectivityGLP-1 receptor agonist semaglutideWeeks of treatmentDouble-blind clinical trialTract integrityEthics Committee of the Capital Region of DenmarkHealth disorders3 Cerebrospinal Fluid
Al Bizri E, Benveniste H. 3 Cerebrospinal Fluid. 2025, 67-76. DOI: 10.1016/b978-0-323-93273-8.00003-1.Peer-Reviewed Original Research
2024
Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease
Koundal S, Chen X, Gursky Z, Lee H, Xu K, Liang F, Xie Z, Xu F, Lin H, Van Nostrand W, Gu X, Elkin R, Tannenbaum A, Benveniste H. Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease. IScience 2024, 27: 111463. PMID: 39720539, PMCID: PMC11667077, DOI: 10.1016/j.isci.2024.111463.Peer-Reviewed Original ResearchCitationsAltmetricElucidating a new path of CSF transport in the CNS
Benveniste H, Thomas J. Elucidating a new path of CSF transport in the CNS. The Lancet Neurology 2024, 23: 553-554. PMID: 38760087, PMCID: PMC11700482, DOI: 10.1016/s1474-4422(24)00164-9.Peer-Reviewed Original ResearchAltmetricIs CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
van Veluw S, Benveniste H, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A, van Osch M. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cellular And Molecular Life Sciences 2024, 81: 239. PMID: 38801464, PMCID: PMC11130115, DOI: 10.1007/s00018-024-05277-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsBrain maps of pCO2, pO2 and pH in aging via homeostatic modeling of neuroimaging data across the lifespan
Mangia S, DiNuzzo M, Dienel G, Behar K, Benveniste H, Giove F, Herculano S, Wolf M, Li X, Filip P, Michaeli S, Rothman D. Brain maps of pCO2, pO2 and pH in aging via homeostatic modeling of neuroimaging data across the lifespan. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/3889.Peer-Reviewed Original ResearchVEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
Boisserand L, Geraldo L, Bouchart J, Kamouh M, Lee S, Sanganahalli B, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez S, Singhabahu R, Robinson M, Askenase M, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing L, Benveniste H, Hyder F, Thomas J. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. Journal Of Experimental Medicine 2024, 221: e20221983. PMID: 38442272, PMCID: PMC10913814, DOI: 10.1084/jem.20221983.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVascular endothelial growth factor-CDeep cervical lymph nodesCentral nervous systemEffect of vascular endothelial growth factor-CMeningeal lymphatic vesselsAmeliorated motor performanceCervical lymph nodesIschemic strokeVEGF-C overexpressionIncreased BDNF signalingAcute ischemic strokeBrain cellsIncreased CSF drainageIschemic stroke outcomesModel of ischemic strokeMouse model of ischemic strokeImmune surveillanceCSF drainageLymph nodesFluid drainageNucleus RNA sequencingLymphatic growthLymphatic drainageMouse modelBDNF signaling
Get In Touch
Copy Link
Contacts
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
Locations
Tompkins Memorial Pavilion
Academic Office
789 Howard Avenue, Fl 3rd, Rm 332
New Haven, CT 06519