Diana Martínez Saucedo, PhD

she/her/hers

Associate Research Scientist in Therapeutic Radiology

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Education

PhD
Universidad Nacional Autonoma de Mexico, Biomedical Sciences (2019)

BS
Universidad Nacional Autonoma de Mexico, Biologia (2011)

About

Titles

Associate Research Scientist in Therapeutic Radiology

Biography

My research focuses on identifying and therapeutically exploiting non-mutational vulnerabilities in pancreatic ductal adenocarcinoma (PDAC), one of the most lethal and treatment-resistant malignancies. I aim to integrate mechanistic studies of tumor-intrinsic dependencies, particularly dysregulated splicing, with immune-based strategies to develop novel RNA-based and immunotherapeutic approaches for aggressive cancers.

Last Updated on May 08, 2026.

Appointments

Therapeutic Radiology
Associate Research Scientist
Primary
Therapeutic Radiology

Education & Training

PhD: Universidad Nacional Autonoma de Mexico, Biomedical Sciences (2019)

Research Associate: Nationwide Children's Hospital (2017)

BS: Universidad Nacional Autonoma de Mexico, Biologia (2011)

Research

Research at a Glance

Publications Timeline

A big-picture view of Diana Martínez Saucedo's research output by year.

6Publications

Publications

2019

Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation.
Callejas BE, Mendoza-Rodríguez MG, Villamar-Cruz O, Reyes-Martínez S, Sánchez-Barrera CA, Rodríguez-Sosa M, Delgado-Buenrostro NL, Martínez-Saucedo D, Chirino YI, León-Cabrera SA, Pérez-Plasencia C, Vaca-Paniagua F, Arias-Romero LE, Terrazas LI. Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation. Int J Cancer 2019, 145: 3126-3139. PMID: 31407335, DOI: 10.1002/ijc.32626.
Peer-Reviewed Original Research
Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages.
Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res 2019, 2019: 2946713. PMID: 31218234, DOI: 10.1155/2019/2946713.
Peer-Reviewed Original Research

2018

Parasites as negative regulators of cancer.
Callejas BE, Martínez-Saucedo D, Terrazas LI. Parasites as negative regulators of cancer. Biosci Rep 2018, 38 PMID: 30266743, DOI: 10.1042/BSR20180935.
Peer-Reviewed Original Research

2017

Helminth-induced Ly6C(hi) monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.
Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6C(hi) monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep 2017, 7: 40814. PMID: 28094319, DOI: 10.1038/srep40814.
Peer-Reviewed Original Research In Press

2015

Uncovering Leishmania-macrophage interplay using imaging flow cytometry.
Terrazas C, Oghumu S, Varikuti S, Martinez-Saucedo D, Beverley SM, Satoskar AR. Uncovering Leishmania-macrophage interplay using imaging flow cytometry. J Immunol Methods 2015, 423: 93-8. PMID: 25967951, DOI: 10.1016/j.jim.2015.04.022.
Peer-Reviewed Original Research
The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection.
Montero-Barrera D, Valderrama-Carvajal H, Terrazas CA, Rojas-Hernández S, Ledesma-Soto Y, Vera-Arias L, Carrasco-Yépez M, Gómez-García L, Martínez-Saucedo D, Becerra-Díaz M, Terrazas LI. The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection. Biomed Res Int 2015, 2015: 615865. PMID: 25664320, DOI: 10.1155/2015/615865.
Peer-Reviewed Original Research

ORCID
0000-0002-8121-6705
Escobar-Hoyos lab
View Lab Website

Academic Achievements & Community Involvement

Activities

activity
Altered splicing mimics chromosome loss and drives pancreatic cancer
05/16/2024 - PresentOral PresentationYale Pancreatic Cancer Research Summit
Details
activity
Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability
09/27/2023 - PresentPoster PresentationAACR Special Conference: Pancreatic Cancer 2023
Details
Boston, MA, United States
Collaborators
Diana Martínez Saucedo, PhD

Honors

honor
Leslie H. Warner Fellowship
07/01/2020Yale School of Medicine AwardYale Cancer Center

Teaching & Mentoring

Mentoring

Deanne Yugawa
Graduate student
2022 - 2025

Willing and Available to Mentor
- Students
- Clinical Fellows

News

See All News

Get In Touch

Contacts

diana.martinezsaucedo@yale.edu

Education

Titles

Biography

Appointments

Therapeutic Radiology

Other Departments & Organizations

Education & Training

Research at a Glance

Publications Timeline

Publications

2019

Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation.

Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages.

2018

Parasites as negative regulators of cancer.

2017

Helminth-induced Ly6C(hi) monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.

2015

Uncovering Leishmania-macrophage interplay using imaging flow cytometry.

The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection.

ORCID

Escobar-Hoyos lab

Activities

Altered splicing mimics chromosome loss and drives pancreatic cancer

Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability

Honors

Leslie H. Warner Fellowship

Mentoring

Deanne Yugawa

Willing and Available to Mentor

News

Yale Researchers Develop Novel Antibody-RNA Therapy for Resistant Cancers

Yale RNA Center Travel Grants Support Attendance at RNA 2025 in San Diego

Yale representation at the Microsymposium on RNA Biology

Innovative Researcher Dr. Giulia Biancon Honored with 2024 Eclipse Award

Contacts