Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV‐1 envelope proteins are largely mediated via human CD5+ B cells
Biswas S, Chang H, Sarkis PT, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV‐1 envelope proteins are largely mediated via human CD5+ B cells. Immunology 2011, 134: 419-433. PMID: 22044090, PMCID: PMC3230796, DOI: 10.1111/j.1365-2567.2011.03501.x.Peer-Reviewed Original ResearchConceptsHumoral immune responseImmune responseBLT miceB cellsB lymphocytesVaccine-induced humoral immune responsesVaccine-induced immune responsesVaccine-induced antibody responsesNon-obese diabetic/T cell-independent pathwayHIV-1 envelope proteinSecondary immune responseSingle intramuscular immunizationSpecific IgM levelsViral envelope antigensB cell subsetsAntigen-specific human antibodiesFollicular B cellsCytokines/growth factorsEnvelope proteinHuman B lymphocytesHuman lymphoid systemMature follicular B cellsWest Nile virus envelope proteinHuman T lymphocytes