Publications

2025

Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndromeZhang Z, Hu X, Du Q, Mo P, Chen X, Luo M, Jiang Q, Deng L, Xiong Y. Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome. BMC Infectious Diseases 2025, 25: 508. PMID: 40217170, DOI: 10.1186/s12879-025-10900-y.
Moderate alcohol-associated hepatitis: A real-world multicenter studyIdalsoaga F, Díaz L, Dunn W, Mehta H, Muñoz K, Caldentey V, Arnold J, Ayares G, Mortuza R, Sarin S, Maiwall R, Zhang W, Qian S, Simonetto D, Singal A, Elfeki M, Ramirez-Cadiz C, Malhi G, Ahmed A, Homsi H, Abid Z, Cabezas J, Echavarría V, Poca M, Soriano G, Cuyas B, Cots M, La Tijera M, Ayala-Valverde M, Perez D, Gomez J, Abraldes J, Al-Karaghouli M, Jalal P, Ibrahim M, García-Tsao G, Goyes D, Skladaný L, Havaj D, Sulejova K, Selcanova S, Rincón D, Chacko K, Restrepo J, Yaquich P, Toro L, Shah V, Arrese M, Kamath P, Bataller R, Arab J. Moderate alcohol-associated hepatitis: A real-world multicenter study. Hepatology Communications 2025, 9: e0673. PMID: 40131003, PMCID: PMC11936654, DOI: 10.1097/hc9.0000000000000673.
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cellsMiller K, Li B, Pierce-Hoffman H, Patel S, Lei X, Rajesh A, Teneche M, Havas A, Gandhi A, Macip C, Lyu J, Victorelli S, Woo S, Lagnado A, LaPorta M, Liu T, Dasgupta N, Li S, Davis A, Korotkov A, Hultenius E, Gao Z, Altman Y, Porritt R, Garcia G, Mogler C, Seluanov A, Gorbunova V, Kaech S, Tian X, Dou Z, Chen C, Passos J, Adams P. p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells. Nature Communications 2025, 16: 2229. PMID: 40044657, PMCID: PMC11882782, DOI: 10.1038/s41467-025-57229-3.
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signalingIsraelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro M, Wei J, Dong H, Homer R, Ring A, Wilen C, Iwasaki A. Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Journal Of Experimental Medicine 2025, 222: e2020124102192025c. PMID: 40009071, PMCID: PMC11864074, DOI: 10.1084/jem.2020124102192025c.
The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturationStacey J, Hrebík D, Nand E, Shetty S, Qu K, Boicu M, Anders-Össwein M, Uchil P, Dick R, Mothes W, Kräusslich H, Müller B, Briggs J. The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation. Nature 2025, 1-7. PMID: 40011770, DOI: 10.1038/s41586-025-08624-9.
Author Correction: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranesLi W, Qin Z, Nand E, Grunst M, Grover J, Bess J, Lifson J, Zwick M, Tagare H, Uchil P, Mothes W. Author Correction: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes. Nature 2025, 639: e15-e15. PMID: 39994465, PMCID: PMC11903299, DOI: 10.1038/s41586-025-08802-9.
Cold and hot fibrosis define clinically distinct cardiac pathologiesMiyara S, Adler M, Umansky K, Häußler D, Bassat E, Divinsky Y, Elkahal J, Kain D, Lendengolts D, Flores R, Bueno-Levy H, Golani O, Shalit T, Gershovits M, Weizman E, Genzelinakh A, Kimchi D, Shakked A, Zhang L, Wang J, Baehr A, Petrover Z, Sarig R, Dorn T, Moretti A, Saez-Rodriguez J, Kupatt C, Tanaka E, Medzhitov R, Krüger A, Mayo A, Alon U, Tzahor E. Cold and hot fibrosis define clinically distinct cardiac pathologies. Cell Systems 2025, 16: 101198. PMID: 39970910, PMCID: PMC11922821, DOI: 10.1016/j.cels.2025.101198.
γ-secretase facilitates retromer-mediated retrograde transportTakeo Y, Crite M, Mehmood K, DiMaio D. γ-secretase facilitates retromer-mediated retrograde transport. Journal Of Cell Science 2025, 138: jcs263538. PMID: 39865938, PMCID: PMC11883284, DOI: 10.1242/jcs.263538.
Targeting the SARS-CoV-2 reservoir in long COVIDProal A, Aleman S, Bomsel M, Brodin P, Buggert M, Cherry S, Chertow D, Davies H, Dupont C, Deeks S, Ely E, Fasano A, Freire M, Geng L, Griffin D, Henrich T, Hewitt S, Iwasaki A, Krumholz H, Locci M, Marconi V, Mehandru S, Muller-Trutwin M, Painter M, Pretorius E, Price D, Putrino D, Qian Y, Roan N, Salmon D, Tan G, VanElzakker M, Wherry E, Van Weyenbergh J, Yonker L, Peluso M. Targeting the SARS-CoV-2 reservoir in long COVID. The Lancet Infectious Diseases 2025 PMID: 39947217, DOI: 10.1016/s1473-3099(24)00769-2.
Nutrient-driven histone code determines exhausted CD8+ T cell fatesMa S, Dahabieh M, Mann T, Zhao S, McDonald B, Song W, Chung H, Farsakoglu Y, Garcia-Rivera L, Hoffmann F, Xu S, Du V, Chen D, Furgiuele J, LaPorta M, Jacobs E, DeCamp L, Oswald B, Sheldon R, Ellis A, Liu L, He P, Wang Y, Jang C, Jones R, Kaech S. Nutrient-driven histone code determines exhausted CD8+ T cell fates. Science 2025, 387: eadj3020. PMID: 39666821, PMCID: PMC11881194, DOI: 10.1126/science.adj3020.
S112 Primary Care Buprenorphine Provision in the US South and Midwest: Prescribing Changes Post-Data Waiver EliminationOsweiler B, Baied M, Narayanan N, Lynch Z, Backes K, Wang K, Humphries D, Heimer R, Marotta P. S112 Primary Care Buprenorphine Provision in the US South and Midwest: Prescribing Changes Post-Data Waiver Elimination. Drug And Alcohol Dependence 2025, 267: 111532. DOI: 10.1016/j.drugalcdep.2024.111532.
S89 The System Isn’t Broken; How do we fix it? The Need for Workplace Education About Harm ReductionNarayanan N, Baied M, Humphries D, Wang K, Marotta P, Heimer R. S89 The System Isn’t Broken; How do we fix it? The Need for Workplace Education About Harm Reduction. Drug And Alcohol Dependence 2025, 267: 111509. DOI: 10.1016/j.drugalcdep.2024.111509.
The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfectionYang R, Chen Q, Jiao F, Yu X, Xiong Y. The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection. Scientific Reports 2025, 15: 4018. PMID: 39893294, PMCID: PMC11787304, DOI: 10.1038/s41598-025-88530-2.
BPS2025 - Structure and inhibition of SARS-CoV-2 spike refolding in membranesMothes W, Grunst M, Qin Z, Dodero-Rojas E, Ding S, Prevost J, Chen Y, Hu Y, Pazgier M, Wu S, Xie X, Finzi A, Onuchic J, Whitford P, Li W. BPS2025 - Structure and inhibition of SARS-CoV-2 spike refolding in membranes. Biophysical Journal 2025, 124: 580a. DOI: 10.1016/j.bpj.2024.11.3011.
Social mixing patterns of United States healthcare personnel at a quaternary health center: a prospective observational studyPischel L, Aguolu O, Ahmed N, Campbell M, Borg R, Duckwall C, Willebrand K, Zaleski A, Paintsil E, Muenker M, Malik A, Kiti M, Warren J, Jenness S, Lopman B, Belsky J, Martinello R, Yildirim I, Ko A, Omer S. Social mixing patterns of United States healthcare personnel at a quaternary health center: a prospective observational study. Infection Control And Hospital Epidemiology 2025, 46: 289-297. PMID: 39880795, PMCID: PMC11883655, DOI: 10.1017/ice.2024.234.
P-271. Contact Patterns of United States Health Care Workers at Quaternary Health Center: Stability of contacts during the post-pandemic eraPischel L, Aguolu O, Ahmed N, Campbell M, Borg R, Duckwall C, Willebrand K, Paintsil E, Muenker M, Malik A, Kiti M, Jenness S, Lopman B, Belsky J, Martinello R, Yildirim I, Ko A, Omer S. P-271. Contact Patterns of United States Health Care Workers at Quaternary Health Center: Stability of contacts during the post-pandemic era. Open Forum Infectious Diseases 2025, 12: ofae631.475. PMCID: PMC11777566, DOI: 10.1093/ofid/ofae631.475.
Correction for Kajaste-Rudnitski et al., “TRIM22 Inhibits HIV-1 Transcription Independently of Its E3 Ubiquitin Ligase Activity, Tat, and NF-κB-Responsive Long Terminal Repeat Elements”Kajaste-Rudnitski A, Marelli S, Pultrone C, Pertel T, Uchil P, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E. Correction for Kajaste-Rudnitski et al., “TRIM22 Inhibits HIV-1 Transcription Independently of Its E3 Ubiquitin Ligase Activity, Tat, and NF-κB-Responsive Long Terminal Repeat Elements”. Journal Of Virology 2025, 99: e02071-24. PMID: 39868830, PMCID: PMC11853098, DOI: 10.1128/jvi.02071-24.
Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II IntronsFedorova O, Luo M, Jagdmann G, Van Zandt M, Sisto L, Pyle A. Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns. ACS Chemical Biology 2025, 20: 378-385. PMID: 39824511, PMCID: PMC11851433, DOI: 10.1021/acschembio.4c00631.
Detection of Pneumococcal Carriage in Asymptomatic Healthcare WorkersWaghela P, Davis R, Campbell M, Datta R, Hislop M, Vega N, Wurst L, Yolda-Carr D, Couch L, Hernandez M, Grant L, Alexander-Parrish R, Arguedas A, Gessner B, Martinello R, Weinberger D, Wyllie A. Detection of Pneumococcal Carriage in Asymptomatic Healthcare Workers. Open Forum Infectious Diseases 2025, 12: ofaf008. PMID: 39917332, PMCID: PMC11800483, DOI: 10.1093/ofid/ofaf008.
mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiaeDolan B, Correa Gaviria T, Dong Y, Cresswell P, Dimopoulos G, Chuang Y, Fikrig E. mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae. Nature Communications 2025, 16: 592. PMID: 39799117, PMCID: PMC11724845, DOI: 10.1038/s41467-025-55902-1.
Bile acid synthesis impedes tumor-specific T cell responses during liver cancerVaranasi S, Chen D, Liu Y, Johnson M, Miller C, Ganguly S, Lande K, LaPorta M, Hoffmann F, Mann T, Teneche M, Casillas E, Mangalhara K, Mathew V, Sun M, Jensen I, Farsakoglu Y, Chen T, Parisi B, Deota S, Havas A, Lee J, Chung H, Schietinger A, Panda S, Williams A, Farber D, Dhar D, Adams P, Feng G, Shadel G, Sundrud M, Kaech S. Bile acid synthesis impedes tumor-specific T cell responses during liver cancer. Science 2025, 387: 192-201. PMID: 39787217, DOI: 10.1126/science.adl4100.
CCL17 Influences Borrelia burgdorferi Infection in the HeartTang X, Yu Q, Cui Y, Hart T, Rivas-Giorgi F, Calloway K, Mohapatra A, Fikrig E. CCL17 Influences Borrelia burgdorferi Infection in the Heart. The Journal Of Infectious Diseases 2025, jiaf011. PMID: 39777514, DOI: 10.1093/infdis/jiaf011.

2024

Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cellsAntani J, Ward T, Emonet T, Turner P. Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2410905121. PMID: 39700139, PMCID: PMC11670125, DOI: 10.1073/pnas.2410905121.
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat heartsGoedeke L, Ma Y, Gaspar R, Nasiri A, Lee J, Zhang D, Galsgaard K, Hu X, Zhang J, Guerrera N, Li X, LaMoia T, Hubbard B, Haedersdal S, Wu X, Stack J, Dufour S, Butrico G, Kahn M, Perry R, Cline G, Young L, Shulman G. SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts. Journal Of Clinical Investigation 2024, 134: e176708. PMID: 39680452, PMCID: PMC11645152, DOI: 10.1172/jci176708.
Non-alcohol-related cirrhosis leads to higher 6-week mortality after acute variceal bleeding than alcohol-related cirrhosisWong Y, Buckholz A, Sim A, Teng M, Wong R, Curry M, De Roza M, Baffy G, Teoh X, Chak E, Rustagi T, Chang J, Wong G, Tandon P, Garcia-Tsao G, Abraldes J, Mohanty A, Fortune B. Non-alcohol-related cirrhosis leads to higher 6-week mortality after acute variceal bleeding than alcohol-related cirrhosis. Clinical Gastroenterology And Hepatology 2024 PMID: 39675401, DOI: 10.1016/j.cgh.2024.10.022.
Confronting risks of mirror lifeAdamala K, Agashe D, Belkaid Y, Bittencourt D, Cai Y, Chang M, Chen I, Church G, Cooper V, Davis M, Devaraj N, Endy D, Esvelt K, Glass J, Hand T, Inglesby T, Isaacs F, James W, Jones J, Kay M, Lenski R, Liu C, Medzhitov R, Nicotra M, Oehm S, Pannu J, Relman D, Schwille P, Smith J, Suga H, Szostak J, Talbot N, Tiedje J, Venter J, Winter G, Zhang W, Zhu X, Zuber M. Confronting risks of mirror life. Science 2024, 386: 1351-1353. PMID: 39666824, DOI: 10.1126/science.ads9158.
Diverse phage communities are maintained stably on a clonal bacterial hostPyenson N, Leeks A, Nweke O, Goldford J, Schluter J, Turner P, Foster K, Sanchez A. Diverse phage communities are maintained stably on a clonal bacterial host. Science 2024, 386: 1294-1300. PMID: 39666794, PMCID: PMC7617280, DOI: 10.1126/science.adk1183.
Enhancing Histology Detection in MASH Cirrhosis for Artificial Intelligence Pathology Platform by Expert Pathologist TrainingGoodman Z, Akbary K, Noureddin M, Ren Y, Chng E, Tai D, Boudes P, Garcia‐Tsao G, Harrison S, Chalasani N. Enhancing Histology Detection in MASH Cirrhosis for Artificial Intelligence Pathology Platform by Expert Pathologist Training. Liver International Communications 2024, 5 DOI: 10.1002/lci2.70007.
mRNA Vaccines Against Tick‐borne DiseasesArora G, Fikrig E. mRNA Vaccines Against Tick‐borne Diseases. 2024, 285-301. DOI: 10.1002/9783527838394.ch10.
A meta-analysis highlights the idiosyncratic nature of tradeoffs in laboratory models of virus evolutionKabengele K, Turner W, Turner P, Ogbunugafor C. A meta-analysis highlights the idiosyncratic nature of tradeoffs in laboratory models of virus evolution. Virus Evolution 2024, 10: veae105. PMID: 39717708, PMCID: PMC11665823, DOI: 10.1093/ve/veae105.
Respiratory equality: let’s stop playing favorites with COVID-19 in the healthcare settingPassaretti C, Bischoff W, Chan J, Diekema D, Doron S, Estelle C, Jacob J, Ku T, Leekha S, Martinello R, Mony V, Munoz-Price L, Murthy R, O’Donnell J, Priest D, Sampson M, Sandora T, Snyder G, Stevens M, Szymczak J, Torriani F, Yokoe D, Marschall J. Respiratory equality: let’s stop playing favorites with COVID-19 in the healthcare setting. Infection Control And Hospital Epidemiology 2024, 46: 333-334. PMID: 39628050, DOI: 10.1017/ice.2024.197.
Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and MortalityZhang Z, Hu X, Du Q, Liu J, Chen X, Mo P, Luo M, Jiang Q, Deng L, Xiong Y. Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality. Journal Of Medical Virology 2024, 96: e70095. PMID: 39624019, DOI: 10.1002/jmv.70095.
A human factors engineering approach to improving hand hygiene qualityBoyce M, Mathew T, Roberts S, Aniskiewicz M, Krechevsky K, Dahlberg S, Frye N, Trumpler J, Evans L, Martinello R, Team T. A human factors engineering approach to improving hand hygiene quality. Human Factors In Healthcare 2024, 6: 100085. DOI: 10.1016/j.hfh.2024.100085.
Sex Differences in Patient-Reported Outcomes and Perception of Ascites Burden Among Outpatients With Decompensated Cirrhosis and Ascites.Wong F, Reddy K, Tandon P, Lai J, Garcia-Tsao G, O'Leary J, Biggins S, Vargas H, Thacker L, Kamath P, Bajaj J. Sex Differences in Patient-Reported Outcomes and Perception of Ascites Burden Among Outpatients With Decompensated Cirrhosis and Ascites. The American Journal Of Gastroenterology 2024 PMID: 39601412, DOI: 10.14309/ajg.0000000000003251.
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma.McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, Huet-Calderwood C, Lou H, Paradkar S, Micevic G, Kaech S, Calderwood D, Turk B, Yan Q, Iwasaki A, Bosenberg M. Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. Cancer Immunology Research 2024, 13: 245-257. PMID: 39589394, DOI: 10.1158/2326-6066.cir-23-0514.
Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancerRobles-Oteíza C, Hastings K, Choi J, Sirois I, Ravi A, Expósito F, de Miguel F, Knight J, López-Giráldez F, Choi H, Socci N, Merghoub T, Awad M, Getz G, Gainor J, Hellmann M, Caron É, Kaech S, Politi K. Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer. Journal Of Experimental Medicine 2024, 222: e20231106. PMID: 39585348, PMCID: PMC11602551, DOI: 10.1084/jem.20231106.
SARS-CoV-2 reprograms murine alveolar macrophages to dampen fluTabachnikova A, Iwasaki A. SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu. Trends In Immunology 2024, 45: 925-927. PMID: 39580310, DOI: 10.1016/j.it.2024.11.002.
Scavenger Receptor CD36 in Tumor-Associated Macrophages Promotes Cancer Progression by Dampening Type-I IFN Signaling.Xu Z, Kuhlmann-Hogan A, Xu S, Tseng H, Chen D, Tan S, Sun M, Tripple V, Bosenberg M, Miller-Jensen K, Kaech S. Scavenger Receptor CD36 in Tumor-Associated Macrophages Promotes Cancer Progression by Dampening Type-I IFN Signaling. Cancer Research 2024, 85: 462-476. PMID: 39546763, PMCID: PMC11788022, DOI: 10.1158/0008-5472.can-23-4027.
Sex differences in postacute infection syndromesSilva J, Iwasaki A. Sex differences in postacute infection syndromes. Science Translational Medicine 2024, 16: eado2102. PMID: 39536120, DOI: 10.1126/scitranslmed.ado2102.
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped virusesYang Y, Treger R, Hernandez-Bird J, Lu P, Mao T, Iwasaki A. A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses. Science Immunology 2024, 9: eadd6608. PMID: 39514636, DOI: 10.1126/sciimmunol.add6608.
Inducible cell lines producing replication-defective human immunodeficiency virus particles containing envelope glycoproteins stabilized in a pretriggered conformationDing H, Nguyen H, Li W, Deshpande A, Zhang S, Jiang F, Zhang Z, Anang S, Mothes W, Sodroski J, Kappes J. Inducible cell lines producing replication-defective human immunodeficiency virus particles containing envelope glycoproteins stabilized in a pretriggered conformation. Journal Of Virology 2024, 98: e01720-24. PMID: 39508605, PMCID: PMC11650979, DOI: 10.1128/jvi.01720-24.
What can building information modeling do for you? A perspective on integration into infection prevention and control programs for patient safetyRoberts S, Mathew T, Tanner W, Martinello R, team H. What can building information modeling do for you? A perspective on integration into infection prevention and control programs for patient safety. Infection Control And Hospital Epidemiology 2024, 46: 112-113. PMID: 39498632, DOI: 10.1017/ice.2024.179.
A place-based spatial analysis of racial inequities in overdose in St. Louis County Missouri, United StatesMarotta P, Leach B, Hutson W, Caplan J, Lohmann B, Hughes C, Banks D, Roll S, Chun Y, Jabbari J, Ancona R, Mueller K, Cooper B, Anasti T, Dell N, Winograd R, Heimer R. A place-based spatial analysis of racial inequities in overdose in St. Louis County Missouri, United States. International Journal Of Drug Policy 2024, 134: 104611. PMID: 39488868, DOI: 10.1016/j.drugpo.2024.104611.
Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissuesLadinsky M, Zhu L, Ullah I, Uchil P, Kumar P, Kay M, Bjorkman P. Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues. Journal Of Virology 2024, 98: e01432-24. PMID: 39475277, PMCID: PMC11575291, DOI: 10.1128/jvi.01432-24.
Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum–Infected Mosquito BitesLapidus S, Goheen M, Sy M, Deme A, Ndiaye I, Diedhiou Y, Mbaye A, Hagadorn K, Sene S, Pouye M, Thiam L, Ba A, Guerra N, Mbengue A, Raduwan H, Gagnon J, Vigan-Womas I, Parikh S, Ko A, Ndiaye D, Fikrig E, Chuang Y, Bei A. Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum–Infected Mosquito Bites. The Journal Of Infectious Diseases 2024, 231: e570-e581. PMID: 39475423, PMCID: PMC11911913, DOI: 10.1093/infdis/jiae525.
Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agentTang X, Cui Y, Namarra U, Tian X, Rivas-Giorgi F, Fikrig E. Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent. MBio 2024, 15: e01754-24. PMID: 39470213, PMCID: PMC11633212, DOI: 10.1128/mbio.01754-24.
Comparative effectiveness of different corticosteroid regimens in severe alcohol-associated hepatitisIslam A, Díaz L, Idalsoaga F, Guizzetti L, Mortuza R, Dunn W, Singal A, Simonetto D, Ramirez-Cadiz C, Zhang W, Qian S, Cabezas J, Sarin S, Maiwall R, Jalal P, La Tijera F, Skladany L, Bystrianska N, Rincon D, Chacko K, Cots M, Garcia-Tsao G, Abraldes J, Kamath P, Arrese M, Shah V, Bataller R, Arab J. Comparative effectiveness of different corticosteroid regimens in severe alcohol-associated hepatitis. Hepatology Communications 2024, 8: e0573. PMID: 39445912, PMCID: PMC11512629, DOI: 10.1097/hc9.0000000000000573.
The KT Jeang retrovirology prize 2024: Walther MothesMothes W. The KT Jeang retrovirology prize 2024: Walther Mothes. Retrovirology 2024, 21: 16. PMID: 39449025, PMCID: PMC11515334, DOI: 10.1186/s12977-024-00649-8.
Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the trans-Golgi network during virus entryChoi J, Speckhart K, Tsai B, DiMaio D. Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the trans-Golgi network during virus entry. MBio 2024, 15: e02811-24. PMID: 39431827, PMCID: PMC11559006, DOI: 10.1128/mbio.02811-24.
High-fat-diet-induced hepatic insulin resistance per se attenuates murine de novo lipogenesisGoedeke L, Strober J, Suh R, Paolella L, Li X, Rogers J, Petersen M, Nasiri A, Casals G, Kahn M, Cline G, Samuel V, Shulman G, Vatner D. High-fat-diet-induced hepatic insulin resistance per se attenuates murine de novo lipogenesis. IScience 2024, 27: 111175. PMID: 39524330, PMCID: PMC11550620, DOI: 10.1016/j.isci.2024.111175.
Transcriptional repression by HDAC3 mediates T cell exclusion from Kras mutant lung tumorsMcGuire C, Meehan A, Couser E, Bull L, Minor A, Kuhlmann-Hogan A, Kaech S, Shaw R, Eichner L. Transcriptional repression by HDAC3 mediates T cell exclusion from Kras mutant lung tumors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2317694121. PMID: 39388266, PMCID: PMC11494357, DOI: 10.1073/pnas.2317694121.
Aedes aegypti adiponectin receptor-like protein signaling facilitates Zika virus infectionChen T, Marín-López A, Raduwan H, Fikrig E. Aedes aegypti adiponectin receptor-like protein signaling facilitates Zika virus infection. MBio 2024, 15: e02433-24. PMID: 39373507, PMCID: PMC11559040, DOI: 10.1128/mbio.02433-24.
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodiesRichard J, Sannier G, Zhu L, Prévost J, Marchitto L, Benlarbi M, Beaudoin-Bussières G, Kim H, Sun Y, Chatterjee D, Medjahed H, Bourassa C, Delgado G, Dubé M, Kirchhoff F, Hahn B, Kumar P, Kaufmann D, Finzi A. CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies. MBio 2024, 15: e01827-24. PMID: 39373535, PMCID: PMC11559134, DOI: 10.1128/mbio.01827-24.
Targeting Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offsKunisch F, Campobasso C, Wagemans J, Yildirim S, Chan B, Schaudinn C, Lavigne R, Turner P, Raschke M, Trampuz A, Gonzalez Moreno M. Targeting Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offs. Nature Communications 2024, 15: 8572. PMID: 39362854, PMCID: PMC11450229, DOI: 10.1038/s41467-024-52595-w.
Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping ReviewMiller C, Borre C, Green A, Funaro M, Oliveira C, Iwasaki A. Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review. American Journal Of Medicine Open 2024, 12: 100078. PMID: 39639960, PMCID: PMC11617896, DOI: 10.1016/j.ajmo.2024.100078.
Viral antibody response predicts morbidity and mortality in alcohol-associated hepatitis.Hsu C, Wang L, Maestri E, Jacob A, Do W, Mayo S, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Stärkel P, Bataller R, Investigators A, Wang X, Schnabl B. Viral antibody response predicts morbidity and mortality in alcohol-associated hepatitis. Hepatology 2024 PMID: 39325984, DOI: 10.1097/hep.0000000000001046.
Correction: Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasisNokin M, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, Turtoi A, Costanza B, Smargiasso N, Baiwir D, Scheijen J, Schalkwijk C, Leenders J, De Tullio P, Bianchi E, Thiry M, Uchida K, Spiegel D, Cochrane J, Hutton C, De Pauw E, Delvenne P, Belpomme D, Castronovo V, Bellahcène A. Correction: Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. ELife 2024, 13: e103327. PMID: 39312391, PMCID: PMC11419668, DOI: 10.7554/elife.103327.
Diagnostic values of BALF metagenomic next-generation sequencing, BALF real-time PCR and serum BDG for Pneumocystis jirovecii pneumonia in HIV-infected patientsChen Q, Chen X, Mo P, Chen L, Du Q, Hu W, Jiang Q, Zhang Z, Zhang Y, Guo Q, Xiong Y, Deng L. Diagnostic values of BALF metagenomic next-generation sequencing, BALF real-time PCR and serum BDG for Pneumocystis jirovecii pneumonia in HIV-infected patients. Frontiers In Microbiology 2024, 15: 1421660. PMID: 39372273, PMCID: PMC11449763, DOI: 10.3389/fmicb.2024.1421660.
Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathwayXu W, Zhang D, Ma Y, Gaspar R, Kahn M, Nasiri A, Murray S, Samuel V, Shulman G. Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway. Cell Reports 2024, 43: 114746. PMID: 39302831, DOI: 10.1016/j.celrep.2024.114746.
Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes.Petersen M, Yoshino M, Smith G, Gaspar R, Kahn M, Samovski D, Shulman G, Klein S. Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes. Diabetes 2024, 73: 2055-2064. PMID: 39264820, PMCID: PMC11579410, DOI: 10.2337/db24-0083.
HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integrationJang S, Bedwell G, Singh S, Yu H, Arnarson B, Singh P, Radhakrishnan R, Douglas A, Ingram Z, Freniere C, Akkermans O, Sarafianos S, Ambrose Z, Xiong Y, Anekal P, Llopis P, KewalRamani V, Francis A, Engelman A. HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration. Nucleic Acids Research 2024, 52: 11060-11082. PMID: 39258548, PMCID: PMC11472059, DOI: 10.1093/nar/gkae769.
Salp14 epitope-based mRNA vaccination induces early recognition of a tick biteCui Y, Cibichakravarthy B, Tang X, Alameh M, Dwivedi G, Weissman D, Fikrig E. Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite. Vaccine 2024, 42: 126304. PMID: 39236403, PMCID: PMC11416896, DOI: 10.1016/j.vaccine.2024.126304.
Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in MiceUllah I, Symmes K, Keita K, Zhu L, Grunst M, Li W, Mothes W, Kumar P, Uchil P. Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice. Vaccines 2024, 12: 1007. PMID: 39340037, PMCID: PMC11435481, DOI: 10.3390/vaccines12091007.
Understanding emerging and re-emerging viruses to facilitate pandemic preparednessZapatero-Belinchón F, Kumar P, Ott M, Schwartz O, Sigal A. Understanding emerging and re-emerging viruses to facilitate pandemic preparedness. Nature Microbiology 2024, 9: 2208-2211. PMID: 39198691, DOI: 10.1038/s41564-024-01789-5.
Barriers to Effective Infection Prevention in the Neonatal Intensive Care UnitWeser V, Crocker A, Murray T, Wright J, Truesdell E, Ciaburri R, Marks A, Martinello R, Hieftje K, Team H. Barriers to Effective Infection Prevention in the Neonatal Intensive Care Unit. Advances In Neonatal Care 2024, 24: 475-484. PMID: 39196970, DOI: 10.1097/anc.0000000000001195.
Characterization and implementation of the MarathonRT template-switching reaction to expand the capabilities of RNA-SeqGuo L, Grinko A, Olson S, Leipold A, Graveley B, Saliba A, Pyle A. Characterization and implementation of the MarathonRT template-switching reaction to expand the capabilities of RNA-Seq. RNA 2024, 30: rna.080032.124. PMID: 39174298, PMCID: PMC11482623, DOI: 10.1261/rna.080032.124.
Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activationLaMoia T, Hubbard B, Guerra M, Nasiri A, Sakuma I, Kahn M, Zhang D, Goodman R, Nathanson M, Sancak Y, Perelis M, Mootha V, Shulman G. Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation. Cell Metabolism 2024, 36: 2329-2340.e4. PMID: 39153480, PMCID: PMC11446666, DOI: 10.1016/j.cmet.2024.07.016.
ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responsesKaymak I, Watson M, Oswald B, Ma S, Johnson B, DeCamp L, Mabvakure B, Luda K, H. E, Lau K, Fu Z, Muhire B, Kitchen-Goosen S, Vander Ark A, Dahabieh M, Samborska B, Vos M, Shen H, Fan Z, Roddy T, Kingsbury G, Sousa C, Krawczyk C, Williams K, Sheldon R, Kaech S, Roy D, Jones R. ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses. Journal Of Experimental Medicine 2024, 221: e20231820. PMID: 39150482, PMCID: PMC11329787, DOI: 10.1084/jem.20231820.
Structure and inhibition of SARS-CoV-2 spike refolding in membranesGrunst M, Qin Z, Dodero-Rojas E, Ding S, Prévost J, Chen Y, Hu Y, Pazgier M, Wu S, Xie X, Finzi A, Onuchic J, Whitford P, Mothes W, Li W. Structure and inhibition of SARS-CoV-2 spike refolding in membranes. Science 2024, 385: 757-765. PMID: 39146425, PMCID: PMC11449073, DOI: 10.1126/science.adn5658.
Vaccination to Prevent Lyme Disease: A Movement Towards Anti-Tick ApproachesJohnson E, Hart T, Fikrig E. Vaccination to Prevent Lyme Disease: A Movement Towards Anti-Tick Approaches. The Journal Of Infectious Diseases 2024, 230: s82-s86. PMID: 39140718, PMCID: PMC11322886, DOI: 10.1093/infdis/jiae202.
Protein folding and quality control during nuclear transportMallik S, Poch D, Burick S, Schlieker C. Protein folding and quality control during nuclear transport. Current Opinion In Cell Biology 2024, 90: 102407. PMID: 39142062, DOI: 10.1016/j.ceb.2024.102407.
Adverse Food Reactions: Physiological and Ecological PerspectivesKorn L, Kutyavin V, Bachtel N, Medzhitov R. Adverse Food Reactions: Physiological and Ecological Perspectives. Annual Review Of Nutrition 2024, 44: 155-178. PMID: 38724028, DOI: 10.1146/annurev-nutr-061021-022909.
The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivityMarin-Lopez A, Huck J, Esterly A, Azcutia V, Rosen C, Garcia-Milian R, Sefik E, Vidal-Pedrola G, Raduwan H, Chen T, Arora G, Halene S, Shaw A, Palm N, Flavell R, Parkos C, Thangamani S, Ring A, Fikrig E. The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity. Science Immunology 2024, 9: eadk9872-eadk9872. PMID: 39121194, PMCID: PMC11924945, DOI: 10.1126/sciimmunol.adk9872.
Long COVID science, research and policyAl-Aly Z, Davis H, McCorkell L, Soares L, Wulf-Hanson S, Iwasaki A, Topol E. Long COVID science, research and policy. Nature Medicine 2024, 30: 2148-2164. PMID: 39122965, DOI: 10.1038/s41591-024-03173-6.
Anopheles gambiae lacking AgTRIO probe inefficiently on a mammalian hostChuang Y, Dong Y, Stone H, Abouneameh S, Tang X, Raduwan H, Dimopoulos G, Fikrig E. Anopheles gambiae lacking AgTRIO probe inefficiently on a mammalian host. Cell Reports 2024, 43: 114600. PMID: 39126653, PMCID: PMC11407849, DOI: 10.1016/j.celrep.2024.114600.
Relationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial designAl-Karaghouli M, Ventura-Cots M, Wong Y, Genesca J, Bosques F, Brown R, Mathurin P, Louvet A, Shawcross D, Vargas V, Verna E, Schnabl B, Caballeria J, Shah V, Kamath P, Lucey M, Garcia-Tsao G, Bataller R, Abraldes J. Relationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial design. Hepatology Communications 2024, 8: e0495. PMID: 39082963, DOI: 10.1097/hc9.0000000000000495.
SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacityPeña-Hernández M, Alfajaro M, Filler R, Moriyama M, Keeler E, Ranglin Z, Kong Y, Mao T, Menasche B, Mankowski M, Zhao Z, Vogels C, Hahn A, Kalinich C, Zhang S, Huston N, Wan H, Araujo-Tavares R, Lindenbach B, Homer R, Pyle A, Martinez D, Grubaugh N, Israelow B, Iwasaki A, Wilen C. SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity. Nature Microbiology 2024, 9: 2038-2050. PMID: 39075235, DOI: 10.1038/s41564-024-01765-z.
Internal tremors and vibrations in long COVID: a cross-sectional studyZhou T, Sawano M, Arun A, Caraballo C, Michelsen T, McAlpine L, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz H. Internal tremors and vibrations in long COVID: a cross-sectional study. The American Journal Of Medicine 2024 PMID: 39069199, DOI: 10.1016/j.amjmed.2024.07.008.
Microbe Profile: Bacteriophage ϕ6: a model for segmented RNA viruses and the evolutionary consequences of viral ‘sex’Turner P, Chao L. Microbe Profile: Bacteriophage ϕ6: a model for segmented RNA viruses and the evolutionary consequences of viral ‘sex’. Microbiology 2024, 170: 001467. PMID: 39046321, PMCID: PMC11316545, DOI: 10.1099/mic.0.001467.
Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitisKreimeyer H, Gonzalez C, Fondevila M, Hsu C, Hartmann P, Zhang X, Stärkel P, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Gonzalez D, Schnabl B. Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis. Gut 2024, 74: 103-115. PMID: 39033024, PMCID: PMC11631684, DOI: 10.1136/gutjnl-2024-332730.
Evolutionary MedicineStearns S, Medzhitov R. Evolutionary Medicine. 2024 DOI: 10.1093/oso/9780192871978.001.0001.
Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformationZhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia A, Chuang G, Geng H, Lai Y, Zhou T, Mascola J, Mothes W, Kwong P, Lusso P. Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation. Cell Reports 2024, 43: 114518. PMID: 39028623, PMCID: PMC11459465, DOI: 10.1016/j.celrep.2024.114518.
UBXN3B is crucial for B lymphopoiesisGeng T, Yang D, Lin T, Harrison A, Wang B, Cao Z, Torrance B, Fan Z, Wang K, Wang Y, Yang L, Haynes L, Cheng G, Vella A, Flavell R, Pereira J, Fikrig E, Wang P. UBXN3B is crucial for B lymphopoiesis. EBioMedicine 2024, 106: 105248. PMID: 39018756, PMCID: PMC11287013, DOI: 10.1016/j.ebiom.2024.105248.
Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infectionSamaddar S, Rolandelli A, O’Neal A, Laukaitis-Yousey H, Marnin L, Singh N, Wang X, Butler L, Rangghran P, Kitsou C, Cabrera Paz F, Valencia L, R. Ferraz C, Munderloh U, Khoo B, Cull B, Rosche K, Shaw D, Oliver J, Narasimhan S, Fikrig E, Pal U, Fiskum G, Polster B, Pedra J. Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection. Nature Microbiology 2024, 9: 2278-2291. PMID: 38997520, PMCID: PMC11926704, DOI: 10.1038/s41564-024-01756-0.
The West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional rolesHuston N, Tsao L, Brackney D, Pyle A. The West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2312080121. PMID: 38985757, PMCID: PMC11260092, DOI: 10.1073/pnas.2312080121.
EASL International Recognition Award Recipient 2024: Prof. Norah TerraultButi M, Campos-Varela I, Garcia-Tsao G. EASL International Recognition Award Recipient 2024: Prof. Norah Terrault. Journal Of Hepatology 2024, 81: 9-10. DOI: 10.1016/j.jhep.2024.04.012.
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in childrenWatkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.
T50 Receipt of Prescribed Opioids and Benzodiazepines After Non-Fatal Overdose and Risk of Subsequent OverdoseHowell B, Black A, Lin H, Lauretta G, Heimer R, Hawk K, D'Onofrio G, Fiellin D, Becker W. T50 Receipt of Prescribed Opioids and Benzodiazepines After Non-Fatal Overdose and Risk of Subsequent Overdose. Drug And Alcohol Dependence 2024, 260: 110499. DOI: 10.1016/j.drugalcdep.2023.110499.
W48 The Development of a Conceptual Model to Assess Intersectional Stigma’s Role in Shaping Rural Primary Care Providers’ Decisions to Implement Harm Reduction, Buprenorphine, and HIV PreventionMarotta P, Backes K, Baied M, Filiatreau L, Winograd R, Reno H, Wang K, Heimer R, McDannold C, Cavazos P. W48 The Development of a Conceptual Model to Assess Intersectional Stigma’s Role in Shaping Rural Primary Care Providers’ Decisions to Implement Harm Reduction, Buprenorphine, and HIV Prevention. Drug And Alcohol Dependence 2024, 260: 110666. DOI: 10.1016/j.drugalcdep.2023.110666.
Management of acute variceal bleedingMohanty A, Garcia-Tsao G. Management of acute variceal bleeding. Clinical Liver Disease 2024, 23: e0176. PMID: 38952694, PMCID: PMC11216663, DOI: 10.1097/cld.0000000000000176.
Using qualitative system dynamics modeling to understand overdose bystander behavior in the context of Connecticut’s Good Samaritan Laws and identify effective policy optionsThompson R, Sabounchi N, Ali S, Heimer R, D’Onofrio G, Heckmann R. Using qualitative system dynamics modeling to understand overdose bystander behavior in the context of Connecticut’s Good Samaritan Laws and identify effective policy options. Harm Reduction Journal 2024, 21: 124. PMID: 38937759, PMCID: PMC11210010, DOI: 10.1186/s12954-024-00990-3.
Neutralizing antibodies after nebulized phage therapy in cystic fibrosis patientsBernabéu-Gimeno M, Pardo-Freire M, Chan B, Turner P, Gil-Brusola A, Pérez-Tarazona S, Carrasco-Hernández L, Quintana-Gallego E, Domingo-Calap P. Neutralizing antibodies after nebulized phage therapy in cystic fibrosis patients. Med 2024, 5: 1096-1111.e6. PMID: 38917792, DOI: 10.1016/j.medj.2024.05.017.
Zika virus exists in enterocytes and enteroendocrine cells of the Aedes aegypti midgutChen T, Raduwan H, Marín-López A, Cui Y, Fikrig E. Zika virus exists in enterocytes and enteroendocrine cells of the Aedes aegypti midgut. IScience 2024, 27: 110353. PMID: 39055935, PMCID: PMC11269924, DOI: 10.1016/j.isci.2024.110353.
First encounter with SARS-CoV-2: immune portraits of COVID susceptibilityIsraelow B, Iwasaki A. First encounter with SARS-CoV-2: immune portraits of COVID susceptibility. Nature 2024, 631: 33-35. PMID: 38898251, DOI: 10.1038/d41586-024-01644-x.
Experimental Evolution Studies in Φ6 CystovirusSinghal S, Balitactac A, Nayagam A, Bahrami P, Nayeem S, Turner P. Experimental Evolution Studies in Φ6 Cystovirus. Viruses 2024, 16: 977. PMID: 38932268, PMCID: PMC11209170, DOI: 10.3390/v16060977.
1571-P: CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction–Associated SteatohepatitisSAKUMA I, GASPAR R, NASIRI A, KAHN M, ZHENG J, GUERRA M, YIMLAMAI D, MURRAY S, PERELIS M, BARNES W, VATNER D, PETERSEN K, SAMUEL V, SHULMAN G. 1571-P: CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction–Associated Steatohepatitis. Diabetes 2024, 73 DOI: 10.2337/db24-1571-p.
292-OR: Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction–Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid DropletsSAKUMA I, GASPAR R, NASIRI A, KAHN M, GUERRA M, YIMLAMAI D, MURRAY S, PERELIS M, BARNES W, VATNER D, PETERSEN K, SAMUEL V, SHULMAN G. 292-OR: Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction–Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid Droplets. Diabetes 2024, 73 DOI: 10.2337/db24-292-or.
Evolutionary Invasion Analysis of Modern Epidemics Highlights the Context-Dependence of Virulence EvolutionSurasinghe S, Kabengele K, Turner P, Ogbunugafor C. Evolutionary Invasion Analysis of Modern Epidemics Highlights the Context-Dependence of Virulence Evolution. Bulletin Of Mathematical Biology 2024, 86: 88. PMID: 38877355, PMCID: PMC11178639, DOI: 10.1007/s11538-024-01313-0.
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanismsHart T, Sonnert N, Tang X, Chaurasia R, Allen P, Hunt J, Read C, Johnson E, Arora G, Dai Y, Cui Y, Chuang Y, Yu Q, Rahman M, Mendes M, Rolandelli A, Singh P, Tripathi A, Ben Mamoun C, Caimano M, Radolf J, Lin Y, Fingerle V, Margos G, Pal U, Johnson R, Pedra J, Azad A, Salje J, Dimopoulos G, Vinetz J, Carlyon J, Palm N, Fikrig E, Ring A. An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms. Cell 2024, 187: 4113-4127.e13. PMID: 38876107, DOI: 10.1016/j.cell.2024.05.023.
Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular Proteins in Brain CellsHowell R, Wang S, Khambete M, McDonald D, Spiegel D. Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular Proteins in Brain Cells. Journal Of The American Chemical Society 2024, 146: 16404-16411. PMID: 38855935, DOI: 10.1021/jacs.3c13320.

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