1995
An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies.
Fikrig E, Liu B, Fu LL, Das S, Smallwood JI, Flavell RA, Persing DH, Schoen RT, Barthold SW, Malawista SE. An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies. The Journal Of Immunology 1995, 155: 5700-4. PMID: 7499856, DOI: 10.4049/jimmunol.155.12.5700.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acid SequenceAnimalsAntibodies, BacterialAntigens, SurfaceArthritis, InfectiousBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupFemaleFrameshift MutationHumansLipoproteinsLyme DiseaseMiceMice, Inbred C3HMolecular Sequence DataProtein BindingSynovial FluidConceptsSurface protein AOuter surface protein ASynovial fluidChronic Lyme arthritisSynovial fluid samplesSeparate time pointsImmune effectivenessLyme arthritisPassive immunizationProtective antibodiesHuman infectionsHuman AbsProtein ATime pointsNatural infectionInfectionBorrelia burgdorferiMiceOnly factorHuman hostFluid samplesOspAInfected hostHuman materialMicrobial persistence
1994
Target Imbalance: Disparity of Borrelia burgdorferi Genetic Material in Synovial Fluid from Lyme Arthritis Patients
Persing D, Rutledge B, Rys P, Podzorski D, Mitchell P, Ree K, Liu B, Fikrig E, Malawista S. Target Imbalance: Disparity of Borrelia burgdorferi Genetic Material in Synovial Fluid from Lyme Arthritis Patients. The Journal Of Infectious Diseases 1994, 169: 668-672. PMID: 8158048, DOI: 10.1093/infdis/169.3.668.Peer-Reviewed Original ResearchConceptsLyme arthritisClinical specimensLyme arthritis patientsUnderlying pathogenetic mechanismsPolymerase chain reaction studiesSynovial fluid specimensB. burgdorferi infectionArthritis patientsSynovial inflammationPathogenetic mechanismsBurgdorferi infectionPhysiologic imbalanceSynovial fluidFluid specimensEtiologic agentLate manifestationLyme diseaseCultured organismsBorrelia burgdorferiArthritisPatientsDNA reactivityAnalytic sensitivity