2007
Age-Associated Defect in Human TLR-1/2 Function
van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC. Age-Associated Defect in Human TLR-1/2 Function. The Journal Of Immunology 2007, 178: 970-975. PMID: 17202359, DOI: 10.4049/jimmunol.178.2.970.Peer-Reviewed Original ResearchConceptsTLR1 surface expressionCytokine productionTLR functionTNF-alphaSurface expressionMultivariable mixed-effects modelsOlder adultsImpaired vaccine responsesTLR2 surface expressionInfection-related morbidityPeripheral blood monocytesYears of ageVaccine responsesIL-6Aged miceBlood monocytesYoung controlsFlow cytometryMixed effects modelsAge categoriesTLR1/2TLREffects modelN-palmitoylAdults
1998
Borrelia burgdorferi-Infected, Interleukin-6-Deficient Mice Have Decreased Th2 Responses and Increased Lyme Arthritis
Anguita J, Rincón M, Samanta S, Barthold S, Flavell R, Fikrig E. Borrelia burgdorferi-Infected, Interleukin-6-Deficient Mice Have Decreased Th2 Responses and Increased Lyme Arthritis. The Journal Of Infectious Diseases 1998, 178: 1512-1515. PMID: 9780277, DOI: 10.1086/314448.Peer-Reviewed Original ResearchConceptsIL-6-deficient miceLyme arthritisT cellsCell responsesCD4 T cell responsesT helper cell responsesInterleukin-6-deficient miceHelper cell responsesLess IL-4CD4 T cellsEffector Th2 cellsT cell responsesBorrelia burgdorferiNaive T cellsMurine Lyme arthritisDays of infectionJoint inflammationTh2 responsesArthritis incidenceIgG2b levelsC57BL/6 miceIL-6Th2 phenotypeIL-4Th2 cells
1997
Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells
Rincón M, Anguita J, Nakamura T, Fikrig E, Flavell R. Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells. Journal Of Experimental Medicine 1997, 185: 461-470. PMID: 9053446, PMCID: PMC2196041, DOI: 10.1084/jem.185.3.461.Peer-Reviewed Original Research