2010
Immunization with Adenoviral-expressed salivary gland proteins (SALPs) decreases spirochete load in a murine model of Lyme borreliosis (52.2)
Ullmann A, Dolan M, Fikrig E, Piesman J, Zeidner N. Immunization with Adenoviral-expressed salivary gland proteins (SALPs) decreases spirochete load in a murine model of Lyme borreliosis (52.2). The Journal Of Immunology 2010, 184: 52.2-52.2. DOI: 10.4049/jimmunol.184.supp.52.2.Peer-Reviewed Original ResearchBurgdorferi infectionMurine modelTick salivary proteinsC3H/HeJ miceDendritic cell expressionCellular immune responsesBorrelia burgdorferi infectionB. burgdorferi infectionLeast partial protectionSalivary proteinsSalivary gland proteinsImmunized miceSpecific immunitySpirochete burdenImmunomodulatory factorsHeJ miceVaccination techniqueImmune responseI. scapularis ticksTarget organsProtein antibodiesCell expressionSpirochete loadTick salivaLyme borreliosis
1995
Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.
Fikrig E, Tao H, Chen M, Barthold SW, Flavell RA. Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. Journal Of Clinical Investigation 1995, 96: 1706-1714. PMID: 7560061, PMCID: PMC185806, DOI: 10.1172/jci118215.Peer-Reviewed Original ResearchConceptsC3H/HeJTransgenic miceLyme borreliosisImmune responseB. burgdorferi-specific antibodyLyme diseaseMajor histocompatibility complex class IBurgdorferi-specific antibodiesRegression of arthritisCellular immune responsesDevelopment of arthritisHistocompatibility complex class IRole of immunityB. burgdorferi antigensComplex class ISurface protein ABorrelia burgdorferi outer surface protein AOuter surface protein ATolerant miceNontransgenic littermatesB6 miceSCID miceImmunodeficient miceB antibodiesC57BL/6 background