2008
A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells
Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, Anderson JF, Bushmich SL, Anthony K, Ledizet M, Fikrig E, Koski RA, Kaplan P. A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells. Vaccine 2008, 27: 213-222. PMID: 18996430, PMCID: PMC2651515, DOI: 10.1016/j.vaccine.2008.10.046.Peer-Reviewed Original ResearchConceptsVaccine candidatesClinical adverse effectsProtein vaccine candidateRecombinant vaccine candidateWNV vaccineAntibody titersHumoral immunityProtective efficacySafe vaccineWNV infectionChallenge modelVaccine antigensAnimal modelsViral protectionHigh dosesProtein antigensAdverse effectsImmunogenicitySerum-free cultureAntigenCell linesNaïve foalsVaccineAluminum hydroxideInfection
2006
Borrelia burgdorferi Lacking BBK32, a Fibronectin-Binding Protein, Retains Full Pathogenicity
Li X, Liu X, Beck DS, Kantor FS, Fikrig E. Borrelia burgdorferi Lacking BBK32, a Fibronectin-Binding Protein, Retains Full Pathogenicity. Infection And Immunity 2006, 74: 3305-3313. PMID: 16714558, PMCID: PMC1479267, DOI: 10.1128/iai.02035-05.Peer-Reviewed Original ResearchConceptsB. burgdorferiFlat ticksB. burgdorferi proteinsTick biteSpirochete acquisitionLyme disease spirocheteAdverse effectsBorrelia burgdorferiFibronectin-binding proteinBurgdorferiFibronectin binding proteinMiceSpirochete life cycleLyme pathogenesisB. burgdorferi B31Mammalian hostsSyringe inoculationExpression profilesBBK32Surface lipoproteinsFibronectin bindingPathogenesisExpressionInfectionTemporal expression profiles