2003
Adaptation of Borrelia burgdorferi in the vector and vertebrate host
Pal U, Fikrig E. Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes And Infection 2003, 5: 659-666. PMID: 12787742, DOI: 10.1016/s1286-4579(03)00097-2.Peer-Reviewed Original ResearchConceptsComplex enzootic cycleUnique adaptive featuresDifferent host environmentsAdaptation of BorreliaMolecular adaptationsRegulatory mechanismsB. burgdorferiHost environmentSensu latoEnzootic cycleExtracellular pathogensDomestic animalsAdaptive featuresBorrelia burgdorferi sensu latoHostBurgdorferi sensu latoCausative agentDiverse rangeArthropodsAdaptationLatoBurgdorferiPathogensLyme diseaseBorrelia
2002
Molecular Adaptation of Borrelia burgdorferi in the Murine Host
Liang FT, Nelson FK, Fikrig E. Molecular Adaptation of Borrelia burgdorferi in the Murine Host. Journal Of Experimental Medicine 2002, 196: 275-280. PMID: 12119353, PMCID: PMC2193918, DOI: 10.1084/jem.20020770.Peer-Reviewed Original ResearchConceptsLipoprotein geneMolecular adaptationsHost immune selection pressureAnalysis of expressionNovel adaptation mechanismSteps of adaptationSelection pressureLyme disease spirocheteB. burgdorferiMurine hostGenesHost tissuesImmune selection pressureAdaptation mechanismsChronic infectionMurine infectionCritical stepHostBorrelia burgdorferiInfectionAdaptationSpirochetesBurgdorferiInitial inoculumPathogens