2004
Roles of PI3K in Neutrophil Function
Hannigan M, Huang C, Wu D. Roles of PI3K in Neutrophil Function. Current Topics In Microbiology And Immunology 2004, 282: 165-175. PMID: 14594217, DOI: 10.1007/978-3-642-18805-3_6.Peer-Reviewed Original Research
2000
Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction
Li Z, Jiang H, Xie W, Zhang Z, Smrcka A, Wu D. Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction. Science 2000, 287: 1046-1049. PMID: 10669417, DOI: 10.1126/science.287.5455.1046.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesChemokine CCL4Chemotactic FactorsChemotaxis, LeukocyteImmunoglobulin lambda-ChainsIsoenzymesMacrophage Inflammatory ProteinsMiceNeutrophil InfiltrationNeutrophilsN-Formylmethionine Leucyl-PhenylalaninePeritonitisPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhospholipase C betaPhosphorylationSignal TransductionSkin UlcerSuperoxidesType C Phospholipases
1999
Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells.
Li L, Yuan H, Xie W, Mao J, Caruso A, Sussman D, Wu D. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. Journal Of Biological Chemistry 1999, 274: 33178. DOI: 10.1016/s0021-9258(17)46631-2.Peer-Reviewed Original Research
1998
Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13
Mao J, Xie W, Yuan H, Simon M, Mano H, Wu D. Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13. The EMBO Journal 1998, 17: 5638-5646. PMID: 9755164, PMCID: PMC1170892, DOI: 10.1093/emboj/17.19.5638.Peer-Reviewed Original ResearchConceptsNon-receptor tyrosine kinase familySerum response factorExpression of Galpha12SRF activationRho-independent pathwayThrombin effectTyrosine kinase familyActivation of SRFNon-receptor tyrosine kinaseG12/13 proteinsRho-dependent pathwayInvolvement of RhoTec kinasesActive alpha subunitG12 familyActivationTransient transfection systemTyrosine kinaseAlpha subunitCellsNIH 3T3 cellsKinase-deficient mutantKinaseRegulation of Rho