2024
TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease
Pellowe A, Wu M, Kang T, Chung T, Ledesma-Mendoza A, Herzog E, Levchenko A, Odell I, Varga J, Gonzalez A. TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease. American Journal Of Pathology 2024, 194: 1171-1184. PMID: 38548268, PMCID: PMC11220919, DOI: 10.1016/j.ajpath.2024.02.021.Peer-Reviewed Original ResearchMechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasis
2022
Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis
Korde A, Haslip M, Ahangari F, Pober J, Chupp G, Manes P, Gonzalez A, Takyar S. Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis. 2022, a5684-a5684. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5684.Peer-Reviewed Original Research
2018
Physical and biochemical interactions drive fibrocytes accumulation in the scleroderma lung matrix
Sun H, Winkler J, Minasyan M, Pan H, Desai O, Pellowe A, Li J, Peng X, Gonzalez A, Herzog E. Physical and biochemical interactions drive fibrocytes accumulation in the scleroderma lung matrix. 2018, lsc-1176. DOI: 10.1183/13993003.congress-2018.lsc-1176.Peer-Reviewed Original ResearchStroke Repair via Biomimicry of the Subventricular Zone
Matta R, Gonzalez A. Stroke Repair via Biomimicry of the Subventricular Zone. Frontiers In Materials 2018, 5: 15. DOI: 10.3389/fmats.2018.00015.Peer-Reviewed Original ResearchSubventricular zoneFunctional recoverySVZ nicheParticular neural stem cellsCurrent stroke therapiesEndogenous reparative mechanismsPeri-infarct areaBlood-brain barrierCause of deathEndogenous repair mechanismsMagnetic resonance imagingStem cellsNeural stem cellsResident cell typesSVZ microenvironmentCell typesStroke therapyNeurons migrateReparative mechanismsAxonal connectionsEpendymal cellsFunctional restorationResident cellsResonance imagingStroke repair
2015
Proteomic Analysis of the Pericyte Derived Extracellular Matrix
Brown L, Sava P, Garcia C, Gonzalez A. Proteomic Analysis of the Pericyte Derived Extracellular Matrix. Cellular And Molecular Bioengineering 2015, 8: 349-363. DOI: 10.1007/s12195-015-0408-5.Peer-Reviewed Original ResearchMatrix proteinsStructural ECM proteinsBasic cellular responsesExtracellular matrix proteinsFunctional annotationProteomic analysisRegulatory signalsCell rufflingECM proteinsCellular responsesWestern blot analysisECM componentsExtracellular matrixEndothelial cell tubule formationFirst characterizationProteinMigratory velocityBlot analysisTubule formationECMNeutrophil polarizationStructural collagenVascular integrityLC/MS-MSBasement membrane
2014
Role of Pericytes in Tissue Engineering
Lauridsen H, Gonzalez A. Role of Pericytes in Tissue Engineering. 2014, 17-36. DOI: 10.1201/b16777-4.Peer-Reviewed Original ResearchChemically- and mechanically-tunable porated polyethylene glycol gels for leukocyte integrin independent and dependent chemotaxis
Lauridsen H, Walker B, Gonzalez A. Chemically- and mechanically-tunable porated polyethylene glycol gels for leukocyte integrin independent and dependent chemotaxis. Technology 2014, 2: 133-143. DOI: 10.1142/s2339547814500113.Peer-Reviewed Original ResearchHuman extracellular matrixExtracellular matrixInflammatory researchECM compositionBiochemical propertiesDependent chemotaxisProtein presentationProtein conjugationLeukocyte integrinsGrowth factorPolyethylene glycol hydrogelsGlass coverslipsGlycol hydrogelsPolyethylene glycol gelComplex mixturesProteinIntegrinsHydrogel pore sizeTranswellProteoglycansChemotaxisChronic inflammatory diseaseRecruitmentMembraneLeukocyte migration
2012
Approaches in extracellular matrix engineering for determination of adhesion molecule mediated single cell function
Ayres-Sander C, Gonzalez A. Approaches in extracellular matrix engineering for determination of adhesion molecule mediated single cell function. Frontiers In Biology 2012, 8: 32-49. DOI: 10.1007/s11515-012-1199-x.Peer-Reviewed Original ResearchCell-ECM interactionsCell adhesion moleculeExtracellular matrixThree-dimensional matrixCellular processesNative extracellular matrixAdhesion moleculesTwo-dimensional substratesSingle cell functionCell functionCell movementECM proteinsNative proteinPeptide sequencesIntegrin expressionBioactive peptide sequencesCell functionalityMatrix engineeringProteinHuman tissuesCellsDiseased tissuesCadherinMoleculesTissue