W Dean Rupp, PhD
DownloadHi-Res Photo
Cards
Appointments
Therapeutic Radiology
Primary
Contact Info
About
Titles
Professor Emeritus of Therapeutic Radiology
Appointments
Therapeutic Radiology
EmeritusPrimary
Other Departments & Organizations
Education & Training
- PhD
- Yale University, Pharmacology (1965)
- AB
- Oberlin College, Chemistry (1960)
Research
Research at a Glance
Publications Timeline
A big-picture view of W Dean Rupp's research output by year.
74Publications
6,327Citations
Publications
2019
Replisome structure suggests mechanism for continuous fork progression and post-replication repair
Yang W, Seidman M, Rupp W, Gao Y. Replisome structure suggests mechanism for continuous fork progression and post-replication repair. DNA Repair 2019, 81: 102658. PMID: 31303546, PMCID: PMC7467748, DOI: 10.1016/j.dnarep.2019.102658.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDiscontinuous DNA synthesisFork progressionBacteriophage T7 replisomeReplication fork helicaseDNA replication forksDNA polymeraseLagging-strand DNA polymerasesReplication fork progressionLeading-strand polymeraseDouble-strand breaksReplication fork reversalDNA synthesisPost-replication repair
2015
Legacy Biological Materials
Klein R, Fontes B, Rupp W. Legacy Biological Materials. Applied Biosafety 2015, 20: 99-103. DOI: 10.1177/153567601502000205.Peer-Reviewed Original Research
2013
Early days of DNA repair: discovery of nucleotide excision repair and homology-dependent recombinational repair.
Rupp WD. Early days of DNA repair: discovery of nucleotide excision repair and homology-dependent recombinational repair. The Yale Journal Of Biology And Medicine 2013, 86: 499-505. PMID: 24348214, PMCID: PMC3848104.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2005
Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation. 1968.
Rupp WD, Howard-Flanders P. Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation. 1968. DNA Repair 2005, 4: 620-33. PMID: 15889457.Peer-Reviewed Original ResearchCitations
1998
A specific 3′ exonuclease activity of UvrABC
Gordienko I, Rupp W. A specific 3′ exonuclease activity of UvrABC. The EMBO Journal 1998, 17: 626-633. PMID: 9430653, PMCID: PMC1170412, DOI: 10.1093/emboj/17.2.626.Peer-Reviewed Original ResearchCitationsAltmetric
1997
UvrAB activity at a damaged DNA site: is unpaired DNA present?
Gordienko I, Rupp W. UvrAB activity at a damaged DNA site: is unpaired DNA present? The EMBO Journal 1997, 16: 880-888. PMID: 9049316, PMCID: PMC1169688, DOI: 10.1093/emboj/16.4.880.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH Keywords2-AcetylaminofluoreneAdenosine TriphosphatasesBacterial ProteinsDNA AdductsDNA DamageDNA HelicasesDNA RepairDNA, Single-StrandedDNA-Binding ProteinsEndodeoxyribonucleasesEscherichia coliEscherichia coli ProteinsModels, GeneticMutationNucleic Acid ConformationNucleic Acid DenaturationOligodeoxyribonucleotidesThe limited strand‐separating activity of the UvrAB protein complex and its role in the recognition of DNA damage
Gordienko I, Rupp W. The limited strand‐separating activity of the UvrAB protein complex and its role in the recognition of DNA damage. The EMBO Journal 1997, 16: 889-895. PMID: 9049317, PMCID: PMC1169689, DOI: 10.1093/emboj/16.4.889.Peer-Reviewed Original ResearchCitationsAltmetricSabia Virus Incident at Yale University
Gandsman EJ, Aaslestad HG, Ouimeta T, Rupp W. Sabia Virus Incident at Yale University. AIHA Journal 1997, 58: 51-53. PMID: 9018837, DOI: 10.1080/15428119791013080.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
1994
UvrABC Cutting at 3′ Recessed Termini of Undamaged DNA May Be a Model for 5′ Incision at Damaged Sitesa
RUPP W, GORDIENKO I. UvrABC Cutting at 3′ Recessed Termini of Undamaged DNA May Be a Model for 5′ Incision at Damaged Sitesa. Annals Of The New York Academy Of Sciences 1994, 726: 321-323. PMID: 8092693, DOI: 10.1111/j.1749-6632.1994.tb52839.x.Peer-Reviewed Original ResearchCitations
1991
Interaction of the UvrABC endonuclease with DNA containing a psoralen monoadduct or cross-link. Differential effects of superhelical density and comparison of preincision complexes.
Munn MM, Rupp WD. Interaction of the UvrABC endonuclease with DNA containing a psoralen monoadduct or cross-link. Differential effects of superhelical density and comparison of preincision complexes. Journal Of Biological Chemistry 1991, 266: 24748-24756. PMID: 1761569, DOI: 10.1016/s0021-9258(18)54293-9.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
Academic Achievements and Community Involvement
honor The 1986 Weiss Medal
International AwardAssociation for Radiation Research, UKDetails06/12/1986United Kingdomhonor The 1976 Radiation Research Award (later renamed The Michael Fry Award)
International AwardRadiation Research Society, USADetails05/07/1976United States
Links & Media
Get In Touch
Contacts
Email
Academic Office Number
Mailing Address
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States