2024
PO0205 Investigation of Inter-Observer Variability of Rectovaginal Reference Point Definition for Cervical Cancer Brachytherapy
Adefres B, Wallington D, Tien C, Damast S. PO0205 Investigation of Inter-Observer Variability of Rectovaginal Reference Point Definition for Cervical Cancer Brachytherapy. Brachytherapy 2024, 23: s96. DOI: 10.1016/j.brachy.2024.08.140.Peer-Reviewed Original ResearchExternal beam radiotherapyTreatment planning systemCervical cancer brachytherapyObserver 1Inter-observer variationObserver 2High dose rate brachytherapyDose gradientCombined external beam radiotherapyExternal beam radiotherapy doseDose measurementsPhysical doseCancer brachytherapyPosterior vaginal wallCervical cancer patientsBrachytherapy techniquesPlanning systemInter-observer differencesInter-observer variabilityBrachytherapy doseCumulative EQD2HDR-BTVaginal doseBeam radiotherapyVaginal wallPO0222 Feasibility of 3-D Printed Prototypes of Indwelling Intrauterine Tube for Tandem-Based Cervical Brachytherapy
Tien C, Damast S, Glennon A. PO0222 Feasibility of 3-D Printed Prototypes of Indwelling Intrauterine Tube for Tandem-Based Cervical Brachytherapy. Brachytherapy 2024, 23: s105. DOI: 10.1016/j.brachy.2024.08.156.Peer-Reviewed Original ResearchSmit sleeveIntrauterine tubeCervical brachytherapyAnimal modelsClinical useUtero timeCT imagesBeam radiationPrevent perforationBrachytherapyClinical prototypeIn-house methodologyClinicMinutesImplantationSTL fileSleeveCervixIntrauterineDaysUterusUteroLong-termCoefficient of thermal expansionISO testsSaturday, July 13, 202411:30 AM - 12:30 PMGSOR01 Presentation Time: 11:30 AM A Prospective Clinical Trial Assessing Comfort of Brachytherapy with a Novel Tapered Vaginal Applicator
Mahal A, Yu J, Mahal R, Tien C, Adefres B, Damast S. Saturday, July 13, 202411:30 AM - 12:30 PMGSOR01 Presentation Time: 11:30 AM A Prospective Clinical Trial Assessing Comfort of Brachytherapy with a Novel Tapered Vaginal Applicator. Brachytherapy 2024, 23: s72-s73. DOI: 10.1016/j.brachy.2024.08.099.Peer-Reviewed Original ResearchVisual-analogue-scaleVaginal brachytherapyVaginal stretchingVaginal applicationEndometrial cancerAssociated with less painIr-192 seedsDose fall-offClinically significant responseProspective clinical trialPatient-centered evaluationVaginal introitusProspective trialsDose distributionSurface doseVaginal mucosaIr-192Less painNarrow introitusPaired t-testEC patientsConsenting patientsClinical trialsIntroitusPatientsThursday, July 11, 20244:00 PM - 5:00 PM PP01 Presentation Time: 4:00 PM Investigating Shielding as a Dose-Shaping Tool in Flattening Distal Dose Profiles for Single-Channel Vaginal Cylinders
Tien C, Mullane S, Draeger E, Rivard M, Chen Z. Thursday, July 11, 20244:00 PM - 5:00 PM PP01 Presentation Time: 4:00 PM Investigating Shielding as a Dose-Shaping Tool in Flattening Distal Dose Profiles for Single-Channel Vaginal Cylinders. Brachytherapy 2024, 23: s26-s27. DOI: 10.1016/j.brachy.2024.08.020.Peer-Reviewed Original ResearchModel-based dose calculation algorithmsSingle-channel vaginal cylinderDose profilesDose distributionVaginal cylinderCentral axisCustomized shieldingRegions of high doseAnisotropic dose distributionUniform dose profileDose calculation algorithmWater-equivalent materialDose calculation methodMonte CarloIr-192 seedsDose gridIr-192MC simulationsRelative doseShielding materialsCalculation algorithmSource transitionDose optimizationLateral radiusShieldingPO0116 Design and Characterization of a Brachytherapy Applicator with Modulated Shielding (MOSH) for the Treatment of Cervical Cancer
Schwipper C, Mullane S, Draeger E, Chen Z, Rivard M, Tien C. PO0116 Design and Characterization of a Brachytherapy Applicator with Modulated Shielding (MOSH) for the Treatment of Cervical Cancer. Brachytherapy 2024, 23: s92. DOI: 10.1016/j.brachy.2024.08.134.Peer-Reviewed Original ResearchDose distributionBrachytherapy applicationsOAR dosesIr-192TG-43 dose calculation formalismShield geometryReduces dose to OARAAPM TG-43 formalismShielding materialsDose calculation formalismHigh-Z shieldingReduced OAR dosesCalculated dose distributionsTG-43 formalismDose-volume objectivesDose to OARsTreatment of cervical cancerHDR brachytherapy applicatorsHigh-risk clinical target volumeIr-192 sourceImproved dose distributionClinical target volumeSparing OARsTOPAS MCYb-169
2023
Investigating the Relationship between the Dose to the Recto-Vaginal Reference Point and Vaginal Stenosis among Cervical Cancer Patients Treated at a North American Academic Institution
Adefres B, Wallington D, Tien C, Damast S. Investigating the Relationship between the Dose to the Recto-Vaginal Reference Point and Vaginal Stenosis among Cervical Cancer Patients Treated at a North American Academic Institution. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e501. DOI: 10.1016/j.ijrobp.2023.06.1746.Peer-Reviewed Original ResearchVaginal stenosisDose constraintsMedian doseMultivariable Cox proportional hazards regressionCox proportional hazards regressionCohort median ageAdvanced cervical cancerInterstitial needlesKaplan-Meier methodCervical cancer patientsProportional hazards regressionLog-rank testHR-CTV D90MATERIAL/METHODSImage-guided brachytherapyNorth American academic institutionsLACC patientsPrimary endpointCumulative incidenceOnly patientsPatient demographicsMedian ageCervical cancerCancer patientsSingle institutionPO38 Clinical Outcomes Following Brachytherapy for Endometrial Cancer Patients with Narrow Vaginal Anatomy
Adefres B, Tien C, Damast S. PO38 Clinical Outcomes Following Brachytherapy for Endometrial Cancer Patients with Narrow Vaginal Anatomy. Brachytherapy 2023, 22: s84-s85. DOI: 10.1016/j.brachy.2023.06.139.Peer-Reviewed Original ResearchVaginal cuff brachytherapyVaginal recurrenceEndometrial cancerEC patientsVaginal surfaceClinical outcomesVaginal anatomyGrade 2Single-channel vaginal cylinderStage IVb endometrial cancerAdjuvant vaginal cuff brachytherapyConsecutive EC patientsEndometrial cancer patientsExcellent local controlKaplan-Meier methodExternal beam radiotherapyInsertional painBaseline painVaginal stenosisCTCAE v4.0Patient demographicsStage IIIAUrinary toxicityMedian ageMedian BMIPO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay?
Guan F, Draeger E, Carlson D, Chen Z, Tien C. PO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay? Brachytherapy 2023, 22: s97-s98. DOI: 10.1016/j.brachy.2023.06.162.Peer-Reviewed Original ResearchPO77 Dwell Position Sequencing: A Clinically-Viable Approach to Modify Biological Dose in High-Dose-Rate Brachytherapy?
Tien C, Carlson D. PO77 Dwell Position Sequencing: A Clinically-Viable Approach to Modify Biological Dose in High-Dose-Rate Brachytherapy? Brachytherapy 2023, 22: s107. DOI: 10.1016/j.brachy.2023.06.178.Peer-Reviewed Original ResearchPO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model
Tien C, Draeger E, Guan F, Carlson D, Chen Z. PO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model. Brachytherapy 2023, 22: s110. DOI: 10.1016/j.brachy.2023.06.184.Peer-Reviewed Original ResearchTumor control probabilityClinical trialsLinear-quadratic modelNumber of patientsPatient cohort sizeTCP curvesRadiobiological parametersVirtual clinical trialsGy-1Cohort sizeRange of dosesPatient outcomesReference cohortPatientsHeterogeneous cohortVirtual patientsNew trialsRadiobiological parameter valuesClonogenic populationPatient ordersControl probabilityGyInput model parametersTrialsCohortCharacterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons
Guan F, Chen H, Draeger E, Li Y, Aydin R, Tien C, Chen Z. Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons. Precision Radiation Oncology 2023, 7: 84-91. DOI: 10.1002/pro6.1204.Peer-Reviewed Original ResearchX-ray beamMeV electron beamMV photon beamElectron beamMV photonsBeam energyMeV electronsPhoton beamsEnergy dependenceKilovoltage x-ray beamsMinimal energy dependenceClinical photonPhotonsBeamRadiation typesMeVElectronsDependence experimentsFilmsDose-response dependenceResponse dependenceDependenceEnergyNoise ratioEBT3Radiobiological evaluation of the stepping-source effect in single-fraction monotherapy high-dose-rate prostate brachytherapy
Tien C, Chen Z. Radiobiological evaluation of the stepping-source effect in single-fraction monotherapy high-dose-rate prostate brachytherapy. Brachytherapy 2023, 22: 593-606. PMID: 37263898, DOI: 10.1016/j.brachy.2023.03.003.Peer-Reviewed Original ResearchRe: Letter to the editor with regards to “Impact of detector selection on commissioning of Leipzig surface applicators with improving immobilization in high-dose-rate brachytherapy” by Li et al.
Tien C, Draeger E, Pinkham D, Carlson D, Jay Chen Z. Re: Letter to the editor with regards to “Impact of detector selection on commissioning of Leipzig surface applicators with improving immobilization in high-dose-rate brachytherapy” by Li et al. Brachytherapy 2023, 22: 290. PMID: 36707330, DOI: 10.1016/j.brachy.2022.11.004.Commentaries, Editorials and LettersPreliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems
Draeger E, Chen Z, Hansen J, Chiang V, Tien C. Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal Of Applied Clinical Medical Physics 2023, 24: e13907. PMID: 36660774, PMCID: PMC10161057, DOI: 10.1002/acm2.13907.Peer-Reviewed Original ResearchConceptsConformity indexRadiation Therapy Oncology Group conformity indexGK plansSuperior conformity indexNon-metastatic casesPaddick conformity indexDosimetric plan qualityGK patientsBrain metastasesRadiosurgery systemTrigeminal neuralgiaPrescription dosesGamma Knife systemMetastatic casesArteriovenous malformationsPituitary adenomasConformality indexLarge cohortDosimetric comparisonStereotactic radiosurgery systemGK IconPatientsCohortTreatment timeDosimetric resultsLetter to the Editor with regards to “Impact of detector selection on commissioning of Leipzig surface applicators with improving immobilization in high-dose-rate brachytherapy” by Li et al.
CJ Tien, E Draeger, DW Pinkham, DJ Carlson, Z Chen. Letter to the Editor with regards to “Impact of detector selection on commissioning of Leipzig surface applicators with improving immobilization in high-dose-rate brachytherapy” by Li et al. Brachytherapy. E-pub ahead of print. DOI: https://doi.org/10.1016/j.brachy.2022.11.004Commentaries, Editorials and Letters
2022
Implementing a simulation-based curriculum for hybrid intracavitary/interstitial brachytherapy using a new, commercially available, US/MR/CT-compatible gynecologic phantom
Li J, Tien C, Kassick M, Peters G, Damast S. Implementing a simulation-based curriculum for hybrid intracavitary/interstitial brachytherapy using a new, commercially available, US/MR/CT-compatible gynecologic phantom. Brachytherapy 2022, 22: 157-165. PMID: 36528476, DOI: 10.1016/j.brachy.2022.11.006.Peer-Reviewed Original ResearchPO17 Assessment of a Prototype Gynecologic US/MR/CT Phantom for Utilization in Interstitial Brachytherapy Training
Tien C, Li J, Kassick M, Peters G, Damast S. PO17 Assessment of a Prototype Gynecologic US/MR/CT Phantom for Utilization in Interstitial Brachytherapy Training. Brachytherapy 2022, 21: s79. DOI: 10.1016/j.brachy.2022.09.123.Peer-Reviewed Original ResearchAir cavityPrototype phantomHybrid ICCurrent simulation modelsSimulation modelTissue-like materialsCylindrical air cavityDistinct materialsPurpose simulationAverage diameterMaterialsPractical materialsFigure 1Future designPhantomRealistic anatomyPhantom prototypeCompatibilityManufacturersDesirable featuresPhysical compatibilityBasic characteristicsCommercial availabilityNext generationICGPP07 Presentation Time: 9:40 AM Investigating the Efficacy of Simulation-Based Education for Interstitial Gynecologic Brachytherapy Using a Novel US/MR/CT-Compatible Gynecologic Phantom
Li J, Tien C, Kassick M, Peters G, Damast S. GPP07 Presentation Time: 9:40 AM Investigating the Efficacy of Simulation-Based Education for Interstitial Gynecologic Brachytherapy Using a Novel US/MR/CT-Compatible Gynecologic Phantom. Brachytherapy 2022, 21: s38. DOI: 10.1016/j.brachy.2022.09.044.Peer-Reviewed Original ResearchPHSOR05 Presentation Time: 12:50 PM The Effect of Quantum Noise on a Novel Multilateration-Based Brachytherapy Source Localization Approach
Jensen P, Tien C, Chen Z. PHSOR05 Presentation Time: 12:50 PM The Effect of Quantum Noise on a Novel Multilateration-Based Brachytherapy Source Localization Approach. Brachytherapy 2022, 21: s25-s26. DOI: 10.1016/j.brachy.2022.09.023.Peer-Reviewed Original ResearchQuantum noiseSource positionAcquisition timePixel sizePhoton-counting systemParticle detectorsImage fluxesLarge pixel sizeDominant sourceAchievable resolutionPhysics principlesSource strengthAxis displacementCamera systemPoint sourcesParameter rangeSingle camera systemSecond cameraDose reconstructionSystem setupRadiation doseCentral axisDual-camera systemPhotonsSetupPHSPP04 Presentation Time: 3:00 PM The Impact of Sublethal Damage Repair on Biological Dose for a Stepping-Source Brachytherapy Delivery in a Single-Fraction Prostate Treatment
Tien C, Donahue W, Giles D, Chen Z. PHSPP04 Presentation Time: 3:00 PM The Impact of Sublethal Damage Repair on Biological Dose for a Stepping-Source Brachytherapy Delivery in a Single-Fraction Prostate Treatment. Brachytherapy 2022, 21: s32-s33. DOI: 10.1016/j.brachy.2022.09.034.Peer-Reviewed Original Research