Brian Pittman
Statistician 3Cards
About
Research
Publications
2025
Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoringPREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES
Sankar *, Shen X, Colic L, Goldman D, Villa L, Kim J, Pittman B, Scheinost D, Constable R, Blumberg H. PREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES. The International Journal Of Neuropsychopharmacology 2025, 28: i15-i15. PMCID: PMC11814904, DOI: 10.1093/ijnp/pyae059.027.Peer-Reviewed Original ResearchConnectome-based predictive modelingBipolar disorderMood symptomatologyMood symptomsFunctional connectomeYoung Mania Rating ScaleFunctional magnetic resonance imaging dataPredictors of functional impairmentEmotion processing taskMania Rating ScaleMood symptom severityMood symptom scoresBrain functional connectomeMagnetic resonance imaging dataBrain function disturbancesHamilton DepressionPredicting depressionSymptom severityRating ScaleFunctional impairmentDisordersMoodSymptomatologyProcessing tasksDepression
2024
Gender differences in alcohol use disorder trends from 2009–2019: An intersectional analysis
Verplaetse T, Carretta R, Struble C, Pittman B, Roberts W, Zakiniaeiz Y, Peltier M, McKee S. Gender differences in alcohol use disorder trends from 2009–2019: An intersectional analysis. Alcohol 2024, 123: 101-107. PMID: 39579801, PMCID: PMC11871986, DOI: 10.1016/j.alcohol.2024.11.003.Peer-Reviewed Original ResearchRates of alcohol use disordersAlcohol use disorderMarital statusRates of alcohol useDrug Use and Health (NSDUHNational Survey on Drug Use and Health (NSDUHGender differencesIntersectional lensIntersectional analysisEffects of sociodemographic variablesDisorder trendsHousehold incomeNational surveyEmployment statusSociodemographic variablesAlcohol useEducation levelHeightened riskGenderLogistic regressionDemographic characteristicsEmploymentIncomeUrbanizationAdult menVitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone R, Carson R, Malison R, Potenza M, Angarita G. Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study. Biological Psychiatry 2024, 97: 651-658. PMID: 39395473, PMCID: PMC11839384, DOI: 10.1016/j.biopsych.2024.09.028.Peer-Reviewed Original ResearchVentral striatumEffects of medicationDorsal caudateDopamine releaseDorsal putamenDopaminergic tonePlacebo-controlled within-subject studyIncreased amphetamine-induced dopamine releaseAmphetamine-induced dopamine releaseAmphetamine-stimulated dopamine releaseSubstantia nigraDysregulated dopamine functionPositron emission tomography studiesTreatment of ADHDEmission tomography studiesWithin-subject studyPost-amphetamineD2/3 receptorsDopamine functionTransdiagnostic relevanceVitamin DPhasic releaseGlobus pallidusStriatumTyrosine hydroxylase11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Esterlis I, Skosnik P, Radhakrishnan R, Wolf J, Nabulsi N, Ropchan J, Huang Y, Carson R, Naples A, McPartland J. 11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Molecular Psychiatry 2024, 30: 1610-1616. PMID: 39367053, DOI: 10.1038/s41380-024-02776-2.Peer-Reviewed Original ResearchPositron emission tomographySynaptic densityAutistic adultsBrain regionsAutistic featuresClinical phenotype of autismNon-autistic participantsPhenotype of autismNon-autistic individualsRelationship to clinical characteristicsSynaptic vesicle glycoprotein 2AAssociated with clinical measuresPost-mortem studiesPositron emission tomography scanPrefrontal cortexClinician ratingsAutism groupNeural basisBrain areasNeural processesBetween-group differencesVolumetric differencesBinding potentialDensity of synapsesAutismExploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity
Grilo C, Pittman B. Exploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity. International Journal Of Eating Disorders 2024, 57: 2475-2481. PMID: 39247962, PMCID: PMC11631662, DOI: 10.1002/eat.24288.Peer-Reviewed Original ResearchCognitive-behavioral therapyBehavioral weight lossBinge-eating disorderBinge eatingWeight loss outcomesCognitive-behavioral treatmentMediation of behaviorEDE-Q restraintPost-treatmentCognitive-behavioralRestraint ScaleDietary restraintBingeMediation effectEatingEffects of treatmentTreatment effectsDisordersRandomized controlled trialsWeight lossMonths of treatmentHypothesis-testingSecondary analysisRestraintBinge-eatingThe combination of donepezil and cognitive training for improving treatment outcomes for alcohol use disorder: Design of a randomized controlled trial
Yoon G, Sofuoglu M, Petrakis I, Pittman B, Bell M. The combination of donepezil and cognitive training for improving treatment outcomes for alcohol use disorder: Design of a randomized controlled trial. Contemporary Clinical Trials 2024, 145: 107657. PMID: 39111388, PMCID: PMC11423257, DOI: 10.1016/j.cct.2024.107657.Peer-Reviewed Original ResearchCognitive remediation therapyAlcohol use disorderAlcohol use disorder treatment outcomesNeurocognitive functionCombination of donepezilRemediation therapyUse disorderTreatment outcomesDevelopment of alcohol use disordersReduce heavy drinking daysHeavy drinking daysGlobal neurocognitive functioningImprove neurocognitive functionEnhanced neurocognitive functionImprove cognitive functionRandomized controlled trialsReduce alcohol consumptionNeurobiological evidenceDrinking daysNeurocognitive function scoresCognitive trainingVA Connecticut Healthcare SystemCognitive functionImprove treatment outcomesCognitive impairmentDisentangling negative and positive symptoms in schizophrenia and autism spectrum disorder
Corbera S, Wexler B, Bell M, Pittman B, Pelphrey K, Pearlson G, Assaf M. Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder. Schizophrenia Research 2024, 271: 1-8. PMID: 39002525, PMCID: PMC11384336, DOI: 10.1016/j.schres.2024.07.002.Peer-Reviewed Original ResearchAutism spectrum disorderPositive and Negative Syndrome ScaleAutism Diagnostic Observation Schedule-GenericExperiential negative symptomsPositive symptomsNegative symptomsExploratory factor analysisSpectrum disorderNegative Syndrome ScaleTarget negative symptomsSyndrome ScaleDiscriminant function analysisSZ relativesAssociated with quality of lifeSchizophreniaSocial skillsSocial functioningDiagnostic classificationAutismFactor analysisAssociated with qualityPredictor of diagnosisSymptomsDisordersQuality of lifeW68 Greater Coupling of Pain Intensity and Opioid Craving After Delaying Methadone Dose Among Veterans With Opioid Use Disorder
MacLean R, Spinola S, Pittman B, Meyerovich J, Szollosy S, Wolkowicz N, Sofuoglu M. W68 Greater Coupling of Pain Intensity and Opioid Craving After Delaying Methadone Dose Among Veterans With Opioid Use Disorder. Drug And Alcohol Dependence 2024, 260: 110686. DOI: 10.1016/j.drugalcdep.2023.110686.Peer-Reviewed Original ResearchADVANCED CHARACTERIZATION OF ON- ELECTROCARDIOGRAPHIC (ECG) SENSORS’ DISCRIMINATORY POWER IN A HUMAN LABORATORY COCAINE SELF-ADMINISTRATION (SA) PARADIGM
Angarita G, Mayerson T, Pittman B, Nararajan A, Parate A, Marlin B, Gueorguieva R, Potenza M, Ganesan D, Malison R. ADVANCED CHARACTERIZATION OF ON- ELECTROCARDIOGRAPHIC (ECG) SENSORS’ DISCRIMINATORY POWER IN A HUMAN LABORATORY COCAINE SELF-ADMINISTRATION (SA) PARADIGM. Drug And Alcohol Dependence 2024, 260: 110014. DOI: 10.1016/j.drugalcdep.2023.110014.Peer-Reviewed Original Research
News
News
- February 20, 2025Source: BMJ Mental Health
Chronotherapeutic Intervention Targeting Emotion Regulation Brain Circuitry, Symptoms, and Suicide Risk in Adolescents and Young adults With Bipolar Disorder: A Pilot Randomised Trial
- October 16, 2024Source: Biological Psychiatry
Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study
- December 08, 2023Source: American Journal on Addictions
The Influence of Childhood Trauma on the Effects of Delta-9-Tetrahydrocannabinol in Persons with Opioid Use Disorder
- August 03, 2023Source: Drug and Alcohol Dependence
Discriminating cocaine use from other sympathomimetics using wearable electrocardiographic (ECG) sensors